Virtual-pion and two-photon production in pp scattering

Two-photon production in pp scattering is proposed as a means of studying virtual-pion emission. Such a process is complementary to real-pion emission in pp scattering. The virtual-pion signal is embedded in a background of double-photon bremsstrahlung. We have developed a model to describe this background process and show that in certain parts of phase space the virtual-pion signal gives significant contribution. In addition, through interference with the two-photon bremsstrahlung background, one can determine the relative phase of the virtual-pion process

Design, synthesis and antiparasitic evaluation of click phospholipids

A library of seventeen novel ether phospholipid analogues, containing 5-membered heterocyclic rings (1,2,3-triazolyl, isoxazolyl, 1,3,4-oxadiazolyl and 1,2,4-oxadiazolyl) in the lipid portion were designed and synthesized aiming to identify optimised miltefosine analogues. The compounds were evaluated for their in vitro antiparasitic activity against Leishmania infantum and Leishmania donovani intracellular amastigotes, against Trypanosoma brucei brucei and against different developmental stages of Trypanosoma cruzi. The nature of the substituents of the heterocyclic ring (tail) and the oligomethylene spacer between the head group and the heterocyclic ring was found to affect the activity and toxicity of these compounds leading to a significantly improved understanding of their structure\u2013activity relationships. The early ADMET profile of the new derivatives did not reveal major liabilities for the potent compounds. The 1,2,3-triazole derivative 27 substituted by a decyl tail, an undecyl spacer and a choline head group exhibited broad spectrum antiparasitic activity. It possessed low micromolar activity against the intracellular amastigotes of two L. infantum strains and T. cruzi Y strain epimastigotes, intracellular amastigotes and trypomastigotes, while its cytotoxicity concentration (CC50) against THP-1 macrophages ranged between 50 and 100 \ub5M. Altogether, our work paves the way for the development of improved ether phospholipid derivatives to control neglected tropical diseases

On the Predicted and Observed Color Boundaries of the RR Lyrae Instability Strip as a Function of Metallicity

The purpose of the paper is to predict the temperature at the fundamental blue edge (FBE) of the instability strip for RR Lyrae (RRL) variables from the pulsation equation that relates temperature to period, luminosity, and mass. Modern data for the correlations between period, luminosity, and metallicity at the FBE for field and cluster RRL are used for the temperature calculation. The predicted temperatures are changed to B-V colors using an adopted color transformation. The predicted temperatures at the FBE become hotter as [Fe/H] changes from 0 to -1.5, and thereafter cooler as the metallicity decreases to -2.5 and beyond. The temperature range over this interval of metallicity is $\Delta$log $T_e$ = 0.04, or 640 K at 6900K. The predicted color variation is at the level of 0.03 mag in B-V. The predictions are compared with the observed RRL colors at the FBE for both the field and cluster variables, showing general agreement at the level of 0.02 mag in (B-V)$_o$, which, however, is the uncertainty of the reddening corrections. The focus of the problem is then reversed by fitting a better envelope to the observed FBE relation between color and metallicity for metallicities smaller than -1.8 which, when inserted in the pulsation equation, gives a non-linear calibration ....Comment: 34 pages, 11 figures, 2 tables. To appear in March 2006 A

Perioperative fluid and volume management: physiological basis, tools and strategies

Fluid and volume therapy is an important cornerstone of treating critically ill patients in the intensive care unit and in the operating room. New findings concerning the vascular barrier, its physiological functions, and its role regarding vascular leakage have lead to a new view of fluid and volume administration. Avoiding hypervolemia, as well as hypovolemia, plays a pivotal role when treating patients both perioperatively and in the intensive care unit. The various studies comparing restrictive vs. liberal fluid and volume management are not directly comparable, do not differ (in most instances) between colloid and crystalloid administration, and mostly do not refer to the vascular barrier's physiologic basis. In addition, very few studies have analyzed the use of advanced hemodynamic monitoring for volume management