680 research outputs found
Immunocompromise in Gnotobiotic Pigs Induced by Verotoxin-Producing \u3ci\u3eEscherichia coli\u3c/i\u3e (O111:NM)
A verotoxin-producing Escherichia coli serotype O111:NM strain (strain 10049; verotoxin 1 positive) persistently infected experimentally inoculated gnotobiotic pigs, causing attaching-effacing intestinal lesions and chronic diarrhea. Experiments were performed to determine whether persistent infection might be associated with immunocompromise of the host by this organism. Pigs inoculated with this strain had a significant reduction in peripheral blood lymphocytes and lower antibody titers to sheep erythrocytes compared with control pigs. Compared with pigs given a verotoxin-negative pathogenic strain of the same serotype (O111:NM, strain 2430), pigs inoculated with the verotoxin-positive strain had lower peripheral lymphocyte counts and proliferative responses to concanavalin A, phytohemagglutinin, and pokeweed mitogens. The results of this study suggest that strain 10049 has an immunocompromising effect on gnotobiotic pigs
Immunocompromise in Gnotobiotic Pigs Induced by Verotoxin-Producing \u3ci\u3eEscherichia coli\u3c/i\u3e (O111:NM)
A verotoxin-producing Escherichia coli serotype O111:NM strain (strain 10049; verotoxin 1 positive) persistently infected experimentally inoculated gnotobiotic pigs, causing attaching-effacing intestinal lesions and chronic diarrhea. Experiments were performed to determine whether persistent infection might be associated with immunocompromise of the host by this organism. Pigs inoculated with this strain had a significant reduction in peripheral blood lymphocytes and lower antibody titers to sheep erythrocytes compared with control pigs. Compared with pigs given a verotoxin-negative pathogenic strain of the same serotype (O111:NM, strain 2430), pigs inoculated with the verotoxin-positive strain had lower peripheral lymphocyte counts and proliferative responses to concanavalin A, phytohemagglutinin, and pokeweed mitogens. The results of this study suggest that strain 10049 has an immunocompromising effect on gnotobiotic pigs
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.
Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis
Quasi-Quantum Groups, Knots, Three-Manifolds, and Topological Field Theory
We show how to construct, starting from a quasi-Hopf algebra, or
quasi-quantum group, invariants of knots and links. In some cases, these
invariants give rise to invariants of the three-manifolds obtained by surgery
along these links. This happens for a finite-dimensional quasi-quantum group,
whose definition involves a finite group , and a 3-cocycle \om, which was
first studied by Dijkgraaf, Pasquier and Roche. We treat this example in more
detail, and argue that in this case the invariants agree with the partition
function of the topological field theory of Dijkgraaf and Witten depending on
the same data G, \,\om.Comment: 30 page
Characterization of SuperCDMS 1-inch Ge Detectors
The newly commissioned SuperCDMS Soudan experiment aims to search for WIMP dark matter with a sensitivity to cross sections of 5×10^(−45)cm^2 and larger (90% CL upper limit). This goal is facilitated by a new set of germanium detectors, 2.5 times more massive than the ones used in the CDMS-II experiment, and with a different athermal phonon sensor layout that eliminates radial degeneracy in position reconstruction of high radius events. We present characterization data on these detectors, as well as improved techniques for correcting position-dependent variations in pulse shape across the detector. These improvements provide surface-event discrimination sufficient for a reach of 5×10^(−45)cm^2
Analysis of the low-energy electron-recoil spectrum of the CDMS experiment
We report on the analysis of the low-energy electron-recoil spectrum from the
CDMS II experiment using data with an exposure of 443.2 kg-days. The analysis
provides details on the observed counting rate and possible background sources
in the energy range of 2 - 8.5 keV. We find no significant excess in the
counting rate above background, and compare this observation to the recent DAMA
results. In the framework of a conversion of a dark matter particle into
electromagnetic energy, our 90% confidence level upper limit of 0.246
events/kg/day at 3.15 keV is lower than the total rate above background
observed by DAMA by 8.9. In absence of any specific particle physics
model to provide the scaling in cross section between NaI and Ge, we assume a
Z^2 scaling. With this assumption the observed rate in DAMA differs from the
upper limit in CDMS by 6.8. Under the conservative assumption that the
modulation amplitude is 6% of the total rate we obtain upper limits on the
modulation amplitude a factor of ~2 less than observed by DAMA, constraining
some possible interpretations of this modulation.Comment: 4 pages, 3 figure
A Search for WIMPs with the First Five-Tower Data from CDMS
We report first results from the Cryogenic Dark Matter Search (CDMS II)
experiment running with its full complement of 30 cryogenic particle detectors
at the Soudan Underground Laboratory. This report is based on the analysis of
data acquired between October 2006 and July 2007 from 15 Ge detectors (3.75
kg), giving an effective exposure of 121.3 kg-d (averaged over recoil energies
10--100 keV, weighted for a weakly interacting massive particle (WIMP) mass of
60 \gev). A blind analysis, incorporating improved techniques for event
reconstruction and data quality monitoring, resulted in zero observed events.
This analysis sets an upper limit on the WIMP-nucleon spin-independent cross
section of 6.6 cm (4.6 cm when combined
with previous CDMS Soudan data) at the 90% confidence level for a WIMP mass of
60 \gev. By providing the best sensitivity for dark matter WIMPs with masses
above 42 GeV/c, this work significantly restricts the parameter space for
some of the favored supersymmetric models.Comment: 5 pages, 4 figures, submitted to PRL 28 March 200
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