Studies on proper simulation during static testing of forward speed effects on fan noise

Significant differences exist in the noise generated by engines in flight and engines operating on the test stand. It was observed that these differences can be reduced by the use of an inflow control structure (ICS) in the static test configuration. The results of the third phase of a three phase program are described. The work performed in the first two phases which dealt with the development of a model for atmospheric turbulence, studies of fan noise generated by rotor turbulence interaction, and the development of an inflow control structure design system are summarized. The final phase of the program covers procedures for performing static testing with an ICS projecting the resulting static test data to actual flight test data. Included is a procedures report which covers the design system and techniques for static testing and projecting the static data to flight

The Choice of Airport, Airline, and Departure Date and Time: Estimating the Demand for Flights

This paper estimates the demand for flights in an international air travel market using a unique dataset with detailed information not only on flight choices but also on contemporaneous prices and characteristics of all the alternative non-booked flights. The estimation strategy employs a simple discrete choice random utility model that we use to analyze how choices and its response to prices depend on the departing airport, the identity of the carrier, and the departure date and time. The results show that a 10\% increase in prices in a 100-seat aircraft throughout a 100-period selling season decreases quantity demanded by 7.7 seats. We also find that the quantity demanded is more responsive to prices for Delta and American, during morning and evening flights and that the response to prices changes significantly over different departure dates

Genome-Wide Screen of Three Herpesviruses for Protein Subcellular Localization and Alteration of PML Nuclear Bodies

Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many of the proteins encoded by these viruses have not been functionally characterized. As a first step in functional characterization, we determined the subcellular localization of 234 epitope-tagged proteins from herpes simplex virus, cytomegalovirus, and Epstein–Barr virus. Twenty-four of the 93 proteins with nuclear localization formed subnuclear structures. Twelve of these localized to the nucleolus, and five at least partially localized with promyelocytic leukemia (PML) bodies, which are known to suppress viral lytic infection. In addition, two proteins disrupted Cajal bodies, and 19 of the nuclear proteins significantly decreased the number of PML bodies per cell, including six that were shown to be SUMO-modified. These results have provided the first functional insights into over 120 previously unstudied proteins and suggest that herpesviruses employ multiple strategies for manipulating nuclear bodies that control key cellular processes

Manipulating the Hype: contemporary art's response to media cliches

Manipulating the Hype addresses art’s reaction to the barrage of signs produced by the media. The paper researches contemporary art’s response to clichéd media stereotypes and elucidates artists’ multifaceted perspective on overtly obvious yet widely embraced paradigms marketed by the media. Contemporary art’s strategic reconfiguration of media stereotypes is a valuable introspection upon the superficiality and impracticability of advertising and entertainment industry constructs. By reconsidering the mediated image, art has the ability to inspire reevaluation of cultural values. The thesis additionally attempts to ascertain the reinterpretation of media stereotypes as a common thread linking principal art movements and historically significant artworks from around the world since 1960. How does contemporary art respond to the extensive cultural influence of the media? Is a reaction to mass media a thematic commonality linking contemporary artists in the age of globalization? Manipulating the Hype is a dual outcome investigation comprised of written thesis and studio practice. The written thesis combines experience from a lengthy professional practice with historical and theoretical research. The visual thesis consists of twelve photographic works taken at on the Big Island of Hawaii. The images juxtapose artificial icons of power from popular culture with the natural force of the active lava flow. The process of research discloses how the advertising and entertainment industries capitalize upon innate human desires through the manipulative proliferation of archetypal imagery. Furthermore, the thesis establishes the widespread retort to media clichés as a palpable commonality in studio practices worldwide. The findings in the research make evident that although contemporary art does not have sufficient influence to reform the media, it can heighten public awareness of media tactics

3D CT ANGIOGRAPHY OF ABDOMINAL WALL VASCULAR PERFORATORS TO PLAN DIEAP FLAPS

Purpose : Since the first report of TRAM flap reconstruction, there have been numerous studies to reduce complications of elective breast reconstruction. Current methods of preoperative perforator localization can be time-consuming, inaccurate, and imprecise. Thus, we sought to evaluate ultra-high resolution 3D CT angiography for the preoperative mapping of DIEAP flap perforating vessels. Methods: We reviewed all perforator-based breast reconstructions performed over a 5-month period. Candidates for DIEAP flap reconstruction were sent for a focused CT scan of the abdominal wall, using the 64 slice multi-detector CT scanner. Results: This article presents our first 23 flaps in 17 patients with preoperative ultra-high resolution 3D CT angiography. The reconstruction plan changed in three patients (18%). There was one take-back for venous congestion, but no partial or total flap loss. Conclusions: Preoperative perforator flap planning for breast reconstruction utilizing 3D CT angiogram is safe, easy to read, and can change the operative plan. Since the first report of the transverse rectus abdominis myocutaneous (TRAM) flap used for reconstruction of the breast after oncologic resection, 1 there have been numerous modifications to reduce the morbidity of breast reconstruction using abdominal autologous tissues. 2-6 Our institution has seen a dramatic increase in perforator flap breast reconstruction over the past 6 years. During the evolution of surgical techniques from the pedicled TRAM flap, to the free TRAM, to the muscle-sparing free TRAM, to the deep inferior epigastric artery perforator (DIEAP) flap and superficial inferior epigastric artery (SIEA) flap, there has been a constant battle between attempts to minimize morbidity to the patient by reducing the dissection of the anterior abdominal wall, while maximizing flap blood flow and viability. It had been shown that partial flap necrosis and fat necrosis rates in DIEAP flaps are higher than those in Free TRAM flaps for breast reconstruction. 7 However, other reports have found little difference. METHODS AND MATERIALS We conducted an IRB-approved review of all perforator-based autologous tissue breast reconstruction patients at The Johns Hopkins Hospital Avon Foundation Breast Center between October 19, 2005 and March 19, 2006. Each patient has had a minimum of 6-months follow-up. Patient Selection All female patients who presented to The Johns Hopkins Hospital Avon Foundation Breast Center for breast reconstruction following mastectomy for treatment or prevention of breast cancer were evaluated for suitability of immediate or delayed breast reconstruction with free autologous tissue transfer versus implant-based reconstruction. Those women who were candidates for DIEAP flap reconstruction were then sent for a preoperative C

Impact of high resolution 3 tesla MR neurography (MRN) on diagnostic thinking and therapeutic patient management

To evaluate the impact of magnetic resonance neurography (MRN) on diagnostic thinking and therapeutic choices in patients with suspected peripheral neuropathy. IRB approval was obtained for this HIPAA-compliant study. Questionnaires were administered to six surgeons regarding the diagnosis and treatment in 85 patients suspected of having peripheral neuropathy, before (pretest) and after (posttest) MRN. Multiple outcome measures related to diagnostic confidence and surgical decision-making were assessed. The final cohort included 81 patients (30 men and 51 women, age 47 ± 17 years). The following changes were observed from pretest to posttest questionnaires: 23% in nerve involvement (P < 0.05), 48% in degree of confidence of nerve involvement (P < 0.01), 27% in grade of injury (P < 0.05), 33% in differential diagnosis (P < 0.05), 63% in degree of confidence in need for surgery (P < 0.001), 41% in timing of surgery (P < 0.01), 30% in approach to surgery (P < 0.05), 58% in degree of confidence in approach to surgery (P < 0.001), 30% in estimated length of surgery (P < 0.05) and 27% in length of incision (P < 0.05). The dichotomous decision regarding surgical or nonsurgical treatment changed from pro to con in 17%. MRN results significantly influenced the diagnostic thinking and therapeutic recommendations of peripheral nerve surgeons. • In patients with peripheral neuropathy, MRN significantly impacts diagnostic thinking. • In patients with peripheral neuropathy, MRN significantly impacts therapeutic choices. • 3-T MRN should be considered in presurgical planning of patients with peripheral neuropathy