317 research outputs found
Magnetic Vortex Resonance in Patterned Ferromagnetic Dots
We report a high-resolution experimental detection of the resonant behavior
of magnetic vortices confined in small disk-shaped ferromagnetic dots. The
samples are magnetically soft Fe-Ni disks of diameter 1.1 and 2.2 um, and
thickness 20 and 40 nm patterned via electron beam lithography onto microwave
co-planar waveguides. The vortex excitation spectra were probed by a vector
network analyzer operating in reflection mode, which records the derivative of
the real and the imaginary impedance as a function of frequency. The spectra
show well-defined resonance peaks in magnetic fields smaller than the
characteristic vortex annihilation field. Resonances at 162 and 272 MHz were
detected for 2.2 and 1.1 um disks with thickness 40 nm, respectively. A
resonance peak at 83 MHz was detected for 20-nm thick, 2-um diameter disks. The
resonance frequencies exhibit weak field dependence, and scale as a function of
the dot geometrical aspect ratio. The measured frequencies are well described
by micromagnetic and analytical calculations that rely only on known properties
of the dots (such as the dot diameter, thickness, saturation magnetization, and
exchange stiffness constant) without any adjustable parameters. We find that
the observed resonance originates from the translational motion of the magnetic
vortex core.Comment: submitted to PRB, 17 pages, 5 Fig
In-Situ Nuclear Magnetic Resonance Investigation of Strain, Temperature, and Strain-Rate Variations of Deformation-Induced Vacancy Concentration in Aluminum
Critical strain to serrated flow in solid solution alloys exhibiting dynamic strain aging (DSA) or Portevin–LeChatelier effect is due to the strain-induced vacancy production. Nuclear magnetic resonance (NMR) techniques can be used to monitor in situ the dynamical behavior of point and line defects in materials during deformation, and these techniques are nondestructive and noninvasive. The new CUT-sequence pulse method allowed an accurate evaluation of the strain-enhanced vacancy diffusion and, thus, the excess vacancy concentration during deformation as a function of strain, strain rate, and temperature. Due to skin effect problems in metals at high frequencies, thin foils of Al were used and experimental results correlated with models based on vacancy production through mechanical work (vs thermal jogs), while in situ annealing of excess vacancies is noted at high temperatures. These correlations made it feasible to obtain explicit dependencies of the strain-induced vacancy concentration on test variables such as the strain, strain rate, and temperature. These studies clearly reveal the power and utility of these NMR techniques in the determination of deformation-induced vacancies in situ in a noninvasive fashion.
Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer
Androgen deprivation therapy is the cornerstone of prostate cancer therapy. Recent studies have revealed an association between androgen deprivation therapy and cardiovascular adverse effects such as myocardial infarction and stroke. This review summarizes the available research on the cardiovascular risk of men using androgen deprivation therapy. We also discuss racial disparities surrounding both prostate cancer and cardiovascular disease, emphasizing the importance of biological/molecular and socioeconomic factors in assessing baseline risk in patients beginning androgen ablation. Based on the literature, we provide recommendations for monitoring patients who are at high risk for a cardiovascular adverse event while being treated on androgen deprivation therapy. This review aims to present the current research on androgen deprivation therapy and cardiovascular toxicity with an emphasis on racial disparities and provides a framework for clinicians to decrease the cardiovascular morbidity in men that are being treated with hormone therapy
Molecular Dynamics Study of the Nematic-Isotropic Interface
We present large-scale molecular dynamics simulations of a nematic-isotropic
interface in a system of repulsive ellipsoidal molecules, focusing in
particular on the capillary wave fluctuations of the interfacial position. The
interface anchors the nematic phase in a planar way, i.e., the director aligns
parallel to the interface. Capillary waves in the direction parallel and
perpendicular to the director are considered separately. We find that the
spectrum is anisotropic, the amplitudes of capillary waves being larger in the
direction perpendicular to the director. In the long wavelength limit, however,
the spectrum becomes isotropic and compares well with the predictions of a
simple capillary wave theory.Comment: to appear in Phys. Rev.
Hard-Sphere Fluids in Contact with Curved Substrates
The properties of a hard-sphere fluid in contact with hard spherical and
cylindrical walls are studied. Rosenfeld's density functional theory (DFT) is
applied to determine the density profile and surface tension for wide
ranges of radii of the curved walls and densities of the hard-sphere fluid.
Particular attention is paid to investigate the curvature dependence and the
possible existence of a contribution to that is proportional to the
logarithm of the radius of curvature. Moreover, by treating the curved wall as
a second component at infinite dilution we provide an analytical expression for
the surface tension of a hard-sphere fluid close to arbitrary hard convex
walls. The agreement between the analytical expression and DFT is good. Our
results show no signs for the existence of a logarithmic term in the curvature
dependence of .Comment: 15 pages, 6 figure
Nucleocytoplasmic transport: a thermodynamic mechanism
The nuclear pore supports molecular communication between cytoplasm and
nucleus in eukaryotic cells. Selective transport of proteins is mediated by
soluble receptors, whose regulation by the small GTPase Ran leads to cargo
accumulation in, or depletion from the nucleus, i.e., nuclear import or nuclear
export. We consider the operation of this transport system by a combined
analytical and experimental approach. Provocative predictions of a simple model
were tested using cell-free nuclei reconstituted in Xenopus egg extract, a
system well suited to quantitative studies. We found that accumulation capacity
is limited, so that introduction of one import cargo leads to egress of
another. Clearly, the pore per se does not determine transport directionality.
Moreover, different cargo reach a similar ratio of nuclear to cytoplasmic
concentration in steady-state. The model shows that this ratio should in fact
be independent of the receptor-cargo affinity, though kinetics may be strongly
influenced. Numerical conservation of the system components highlights a
conflict between the observations and the popular concept of transport cycles.
We suggest that chemical partitioning provides a framework to understand the
capacity to generate concentration gradients by equilibration of the
receptor-cargo intermediary.Comment: in press at HFSP Journal, vol 3 16 text pages, 1 table, 4 figures,
plus Supplementary Material include
Spin Susceptibility of Ga-Stabilized delta-Pu Probed by {69}^Ga NMR
Spin susceptibility of stabilized \delta phase in the Pu-Ga alloy is studied
by measuring {69,71}^Ga NMR spectra and nuclear spin-lattice relaxation rate
{69}T_{1}^{-1} in the temperature range 5 - 350 K. The shift ({69}^K) of the
{69,71}^Ga NMR line and {69}^T_{1}^{-1} are controlled correspondingly by the
static and the fluctuating in time parts of local magnetic field arisen at
nonmagnetic gallium due to transferred hyperfine coupling with the nearest f
electron environment of the more magnetic Pu. The nonmonotonic with a maximum
around 150 K behavior of {69}^K(T) \chi_{s,5f}(T) is attributed to the
peculiarities in temperature dependence of the f electron spin susceptibility
\chi_{s,5f}(T) in \delta phase of plutonium. The temperature reversibility
being observed in {69}^K(T) data provides strong evidence for an electronic
instability developed with T in f electron bands near the Fermi energy and
accompanied with a pseudogap-like decrease of \chi_{s,5f}(T) at T<150 K. The
NMR data at high temperature are in favor of the mainly localized character of
5f electrons in \delta phase of the alloy with characteristic spin-fluctuation
energy \Gamma(T) T^{0.35(5)}, which is close to $\Gamma(T) T^{0.5} predicted by
Cox et al. [J. Appl. Phys. 57, 3166 (1985)] for 3D Kondo-system above T_Kondo}.
The dynamic spin correlations of 5f electrons become essential to consider for
{69}^T_{1}^{-1}(T) only at T<100 K. However, no NMR evidences favoring
formation of the static magnetic order in \delta-Pu were revealed down to 5K .Comment: 6 pages, 4 figure
Surface layering of liquids: The role of surface tension
Recent measurements show that the free surfaces of liquid metals and alloys
are always layered, regardless of composition and surface tension; a result
supported by three decades of simulations and theory. Recent theoretical work
claims, however, that at low enough temperatures the free surfaces of all
liquids should become layered, unless preempted by bulk freezing. Using x-ray
reflectivity and diffuse scattering measurements we show that there is no
observable surface-induced layering in water at T=298 K, thus highlighting a
fundamental difference between dielectric and metallic liquids. The
implications of this result for the question in the title are discussed.Comment: 5 pages, 4 figures, to appear in Phys. Rev. B. 69 (2004
Hsp21potentiates antifungal drug tolerance in Candida albicans
Peer reviewedPublisher PD
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