Increased accuracy of ligand sensing by receptor internalization

Many types of cells can sense external ligand concentrations with cell-surface receptors at extremely high accuracy. Interestingly, ligand-bound receptors are often internalized, a process also known as receptor-mediated endocytosis. While internalization is involved in a vast number of important functions for the life of a cell, it was recently also suggested to increase the accuracy of sensing ligand as the overcounting of the same ligand molecules is reduced. Here we show, by extending simple ligand-receptor models to out-of-equilibrium thermodynamics, that internalization increases the accuracy with which cells can measure ligand concentrations in the external environment. Comparison with experimental rates of real receptors demonstrates that our model has indeed biological significance.Comment: 9 pages, 4 figures, accepted for publication in Physical Review

MUSE Reveals a Recent Merger in the Post-starburst Host Galaxy of the TDE ASASSN-14li

We present MUSE integral field spectroscopic observations of the host galaxy (PGC 043234) of one of the closest ($z=0.0206$, $D\simeq 90$ Mpc) and best-studied tidal disruption events (TDE), ASASSN-14li. The MUSE integral field data reveal asymmetric and filamentary structures that extend up to $\gtrsim 10$ kpc from the post-starburst host galaxy of ASASSN-14li. The structures are traced only through the strong nebular [O III] $\lambda$5007, [N II] $\lambda$6584, and H$\alpha$ emission lines. The total off nuclear [O III] $\lambda$5007 luminosity is luminosity is $4.7\times 10^{39}$ erg s$^{-1}$ and the ionized H mass is $\rm \sim 10^4(500/n_e)\,M_{\odot}$. Based on the BPT diagram, the nebular emission can be driven by either AGN photoionization or shock excitation, with AGN photoionization favored given the narrow intrinsic line widths. The emission line ratios and spatial distribution strongly resemble ionization nebulae around fading AGNs such as IC 2497 (Hanny's Voorwerp) and ionization "cones" around Seyfert 2 nuclei. The morphology of the emission line filaments strongly suggest that PGC 043234 is a recent merger, which likely triggered a strong starburst and AGN activity leading to the post-starburst spectral signatures and the extended nebular emission line features we see today. We briefly discuss the implications of these observations in the context of the strongly enhanced TDE rates observed in post-starburst galaxies and their connection to enhanced theoretical TDE rates produced by supermassive black-hole binaries.Comment: Accepted for publication in ApJ

Light gravitino production in association with gluinos at the LHC

We study the jets plus missing energy signature at the LHC in a scenario where the gravitino is very light and the gluino is the next-to-lightest supersymmetric particle and promptly decays into a gluon and a gravitino. We consider both associated gravitino production with a gluino and gluino pair production. By merging matrix elements with parton showers, we generate inclusive signal and background samples and show how information on the gluino and gravitino masses can be obtained by simple final state observables.Comment: 18 pages, 8 figures, 1 table; v2: typos corrected, version to appear in JHE

Renewal processes and fluctuation analysis of molecular motor stepping

We model the dynamics of a processive or rotary molecular motor using a renewal processes, in line with the work initiated by Svoboda, Mitra and Block. We apply a functional technique to compute different types of multiple-time correlation functions of the renewal process, which have applications to bead-assay experiments performed both with processive molecular motors, such as myosin V and kinesin, and rotary motors, such as F1-ATPase

SSDSS IV MaNGA - Properties of AGN host galaxies

We present here the characterization of the main properties of a sample of 98 AGN host galaxies, both type-II and type-I, in comparison with those of about 2700 non-active galaxies observed by the MaNGA survey. We found that AGN hosts are morphologically early-type or early-spirals. For a given morphology AGN hosts are, in average, more massive, more compact, more central peaked and rather pressurethan rotational-supported systems. We confirm previous results indicating that AGN hosts are located in the intermediate/transition region between star-forming and non-star-forming galaxies (i.e., the so-called green valley), both in the ColorMagnitude and the star formation main sequence diagrams. Taking into account their relative distribution in terms of the stellar metallicity and oxygen gas abundance and a rough estimation of their molecular gas content, we consider that these galaxies are in the process of halting/quenching the star formation, in an actual transition between both groups. The analysis of the radial distributions of the starformation rate, specific star-formation rate, and molecular gas density shows that the quenching happens from inside-out involving both a decrease of the efficiency of the star formation and a deficit of molecular gas. All the intermediate data-products used to derive the results of our analysis are distributed in a database including the spatial distribution and average properties of the stellar populations and ionized gas, published as a Sloan Digital Sky Survey Value Added Catalog being part of the 14th Data Release: http://www.sdss.org/dr14/manga/manga-data/manga-pipe3d-value-added-catalog/Comment: 48 pages, 14 figures, in press in RMxA