17,409 research outputs found
Time dependent spectral modeling of Markarian 421 during a violent outburst in 2010
We present the results of extensive modeling of the spectral energy
distributions (SEDs) of the closest blazar (z=0.031) Markarian 421 (Mrk 421)
during a giant outburst in February 2010. The source underwent rapid flux
variations in both X-rays and very high energy (VHE) gamma-rays as it evolved
from a low-flux state on 2010 February 13-15 to a high-flux state on 2010
February 17. During this period, the source exhibited significant spectral
hardening from X-rays to VHE gamma-rays while exhibiting a "harder when
brighter" behavior in these energy bands. We reproduce the broadband SED using
a time-dependent multi-zone leptonic jet model with radiation feedback. We find
that an injection of the leptonic particle population with a single power-law
energy distribution at shock fronts followed by energy losses in an
inhomogeneous emission region is suitable for explaining the evolution of Mrk
421 from low- to high-flux state in February 2010. The spectral states are
successfully reproduced by a combination of a few key physical parameters, such
as the maximum minimum cutoffs and power-law slope of the electron
injection energies, magnetic field strength, and bulk Lorentz factor of the
emission region. The simulated light curves and spectral evolution of Mrk 421
during this period imply an almost linear correlation between X-ray flux at
1-10 keV energies and VHE gamma-ray flux above 200 GeV, as has been previously
exhibited by this source. Through this study, a general trend that has emerged
for the role of physical parameters is that, as the flare evolves from a low-
to a high-flux state, higher bulk kinetic energy is injected into the system
with a harder particle population and a lower magnetic field strength.Comment: 13 pages, 5 figures, accepted for publication in MNRA
Diurnal variation in harbour porpoise detection – potential implications for management
Peer reviewedPublisher PD
High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrP in vivo
Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177Diagnosis of transmissible spongiform encephalopathy (TSE) disease in humans and ruminants relies on the detection in post-mortem brain tissue of the protease-resistant form of the host glycoprotein PrP. The presence of this abnormal isoform (PrPSc) in tissues is taken as indicative of the presence of TSE infectivity. Here we demonstrate conclusively that high titers of TSE infectivity can be present in brain tissue of animals that show clinical and vacuolar signs of TSE disease but contain low or undetectable levels of PrPSc. This work questions the correlation between PrPSc level and the titer of infectivity and shows that tissues containing little or no proteinase K-resistant PrP can be infectious and harbor high titers of TSE infectivity. Reliance on protease-resistant PrPSc as a sole measure of infectivity may therefore in some instances significantly underestimate biological properties of diagnostic samples, thereby undermining efforts to contain and eradicate TSEs.https://doi.org/10.1074/jbc.M704329200282pubpub4
The complex network of global cargo ship movements
Transportation networks play a crucial role in human mobility, the exchange
of goods, and the spread of invasive species. With 90% of world trade carried
by sea, the global network of merchant ships provides one of the most important
modes of transportation. Here we use information about the itineraries of
16,363 cargo ships during the year 2007 to construct a network of links between
ports. We show that the network has several features which set it apart from
other transportation networks. In particular, most ships can be classified in
three categories: bulk dry carriers, container ships and oil tankers. These
three categories do not only differ in the ships' physical characteristics, but
also in their mobility patterns and networks. Container ships follow regularly
repeating paths whereas bulk dry carriers and oil tankers move less predictably
between ports. The network of all ship movements possesses a heavy-tailed
distribution for the connectivity of ports and for the loads transported on the
links with systematic differences between ship types. The data analyzed in this
paper improve current assumptions based on gravity models of ship movements, an
important step towards understanding patterns of global trade and bioinvasion.Comment: 7 figures Accepted for publication by Journal of the Royal Society
Interface (2010) For supplementary information, see
http://www.icbm.de/~blasius/publications.htm
Perceived vocal morbidity in a problem asthma clinic
<p>Aims: Asthma treatment has the potential to affect patients' voices. We undertook detailed characterisation of voice morbidity in patients attending a problem asthma clinic, and we determined how patients' perceptions related to objective assessment by an experienced observer.</p>
<p>Methods: Forty-three patients took part in the study. Subjects completed the self-administered voice symptom score (VoiSS) questionnaire and underwent digital voice recording. These voice recordings were scored using the grade–roughness–breathiness–asthenicity–strain system (GRBAS). Laryngoscopy was also performed.</p>
<p>Results: The median VoiSS was 26 (range three to 83). VoiSS were significantly lower in the 17 patients with normal laryngeal structure and function (range four to 46; median 22), compared with the 26 patients with functional or structural laryngeal abnormality (range three to 83; median 33) (95 per cent confidence intervals for difference 0.0–21.0; p = 0.044). The overall grade score for the GRBAS scale did not differ between these two groups, and only 13 patients had a GRBAS score of one or more, recognised as indicating a voice problem. There were positive correlations between related GRBAS score and voice symptom score subscales. Although voice symptom scores were significantly more abnormal in patients with structural and functional abnormalities, this score performed only moderately well as a predictive tool (sensitivity 54 per cent; specificity 71 per cent). Nevertheless, the voice symptom score performed as well as the more labour-intensive GRBAS score (sensitivity 57 per cent; specificity 60 per cent). Patients' inhaled corticosteroid dose (median dose 1000 µg beclomethasone dipropionate or equivalent) had a statistically significant relationship with their overall grade score for the GRBAS scale (r = 0.56; p < 0.001), but not with their VoiSS. Only one patient had evidence of laryngeal candidiasis, and only two had any evidence of abnormality suggesting steroid-induced myopathy.</p>
<p>Conclusions: Vocal morbidity is common in patients with asthma, and should not be immediately attributed to steroid-related candidiasis. The VoiSS merits further, prospective validation as a screening tool for ENT and/or speech and language therapy referral in patients with asthma.</p>
Endothelial Progenitor Cells Enter the Aging Arena
Age is a significant risk factor for the development of vascular diseases, such as atherosclerosis. Although pharmacological treatments, including statins and anti-hypertensive drugs, have improved the prognosis for patients with cardiovascular disease, it remains a leading cause of mortality in those aged 65 years and over. Furthermore, given the increased life expectancy of the population in developed countries, there is a clear need for alternative treatment strategies. Consequently, the relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPCs) play an integral role in the cellular repair mechanisms for endothelial regeneration and maintenance. However, EPCs are subject to age-associated changes that diminish their number in circulation and function, thereby enhancing vascular disease risk. A great deal of research is aimed at developing strategies to harness the regenerative capacity of these cells. In this review, we discuss the current understanding of the cells termed “EPCs,” examine the impact of age on EPC-mediated repair and identify therapeutic targets with potential for attenuating the age-related decline in vascular health via beneficial actions on EPCs
Anomalous Radio-Wave Scattering from Interstellar Plasma Structures
This paper considers scattering screens that have arbitrary spatial
variations of scattering strength transverse to the line of sight, including
screens that are spatially well confined, such as disks and filaments. We
calculate the scattered image of a point source and the observed pulse shape of
a scattered impulse. The consequences of screen confinement include: (1) Source
image shapes that are determined by the physical extent of the screen rather
than by the shapes of much-smaller diffracting microirregularities. These
include image elongations and orientations that are frequency dependent. (2)
Variation with frequency of angular broadening that is much weaker than the
trademark \nu^{-2} scaling law (for a cold, unmagnetized plasma), including
frequency-independent cases; and (3) Similar departure of the pulse broadening
time from the usually expected \nu^{-4} scaling law. We briefly discuss
applications that include scattering of pulses from the Crab pulsar by
filaments in the Crab Nebula; image asymmetries from Galactic scattering of the
sources Cyg X-3, Sgr A*, and NGC 6334B; and scattering of background active
galactic nuclei by intervening galaxies. We also address the consequences for
inferences about the shape of the wavenumber spectrum of electron density
irregularities, which depend on scaling laws for the image size and the pulse
broadening. Future low-frequency (< 100 MHz) array observations will also be
strongly affected by the Galactic structure of scattering material. Our
formalism is derived in the context of radio scattering by plasma density
fluctuations. It is also applicable to optical, UV and X-ray scattering by
grains in the interstellar medium.Comment: 21 pages, LaTeX2e with AASTeX-4.0, 6 PostScript figures, accepted by
ApJ, revised version has minor changes to respond to referee comments and
suggestion
A review of the potential for rare earth element resources from European red muds: examples from Seydişehir, Turkey and Parnassus-Giona, Greece
ArticleRare earth elements (REE) are viewed as ‘critical metals’ due to a complex array of production and political issues, most notably a near monopoly in supply from China. Red mud, the waste product of the Bayer process that produces alumina from bauxite, represents a potential secondary resource of REE. Karst-bauxite deposits represent the ideal source material for REE-enriched red mud as the conditions during formation of the bauxite allow for the retention of REE. The REE pass through the Bayer Process and are concentrated in the waste material. Millions of tonnes of red mud are currently stockpiled in onshore storage facilities across Europe, representing a potential REE resource. Red mud from two case study sites, one in Greece and the other in Turkey, has been found to contain an average of approximately 1 000 ppm total REE, with an enrichment of light over heavy REE. Although this is relatively low grade when compared with typical primary REE deposits (Mountain Pass and Mount Weld up to 80 000 ppm), it is of interest because of the large volumes available, the cost benefits of reprocessing waste, and the low proportion of contained radioactive elements. This work shows that around 12 000 tonnes of REE exist in red mud at the two case study areas alone, with much larger resources existing across Europe as a whole.The research leading to these results has received funding from the European 669 Community’s Seventh Framework Programme ([FP7/2007-2013]) under Grant 670 Agreement no. 309373
Finite Density QCD in the Chiral Limit
We present the first results of an exact simulation of full QCD at finite
density in the chiral limit. We have used a MFA (Microcanonical Fermionic
Average) inspired approach for the reconstruction of the Grand Canonical
Partition Function of the theory; using the fugacity expansion of the fermionic
determinant we are able to move continuously in the () plane with
.Comment: 3 pages, LaTeX, 3 figures, uses espcrc2.sty, psfig. Talk presented by
A. Galante at Lattice 97. Correction of some reference
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