Accumulation of 125I-labelled thiouracil and propylthiouracil in murine melanotic melanomas.

We have shown that thioamides are incorporated as false precursors into melanin during its synthesis. To be clinically useful in the diagnosis or therapy of melanotic melanomas, they would have to be tagged with an appropriate isotope or possibly a cytotoxic moiety. 125I-Thiouracil (125I-TU) is here shown to be accumulated in the melanin of melanotic melanomas transplanted into mice in a similar way as is 14C-thiouracil (14C-TU). 125I-TU gives tumour/liver and tumour/muscle ratios up to 22 and 778 respectively, at 4 days after administration. 125I-TU is accumulated by melanoma cells in vitro more effectively than 14C-TU (125I-TU/14C-TU, 2.7), while the in vivo accumulation into melanomas is slightly lower for 125I-TU as compared to 14C-TU (125I-TU/14C-TU, 0.35). This appears to be due to a partial deiodination (less than 14% of the dose within 4 days) and probably a more rapid excretion of 125I-TU or its metabolite(s). The accumulation of radioactivity in the thyroid can essentially be eliminated by pretreatment with potassium iodide and/or thyroxine. 125I-Propylthiouracil is also accumulated in melanotic melanoma cells in vivo and in vitro, but at a lower level than in 125I-TU and 14C-TU

Den økonomiske Grænse for de forskjellige Bevægkræfters Anvendelse i Landbrugets Tjeneste.

Den økonomiske Grænse for de forskjellige Bevægkræfters Anvendelse i Landbrugets Tjeneste

Beretning om Arbejdsprøve med Kværne, Knusemaskiner og Oliekagebrydere i Randers, samt en Efterprøve med Kværne og Knusemaskiner i Nakskov.

Beretning om Arbejdsprøve med Kværne, Knusemaskiner og Oliekagebrydere i Randers, samt en Efterprøve med Kværne og Knusemaskiner i Nakskov

Arbejdsprøve med Radsaamaskiner, Geduingsspredemaskiner og Godningsmoller.

Arbejdsprøve med Radsaamaskiner, Geduingsspredemaskiner og Godningsmoller

Landbrugets Redskaber og Maskiner 1892.

Landbrugets Redskaber og Maskiner 1892

Landbrugets Bedskaber og Maskiner 1895.

Landbrugets Bedskaber og Maskiner 1895

Beretning om den paa Borreby i Marts 1893 afholdte Prøve med Petroleums lokomobiler til Tærskning

Beretning om den paa Borreby i Marts 1893 afholdte Prøve med Petroleums lokomobiler til Tærsknin

Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews

Maternal obesity is linked with adverse outcomes for mothers and babies. To get an overview of risks related to obesity in pregnant women, a systematic review of reviews was conducted. For inclusion, reviews had to compare pregnant women of healthy weight with women with obesity, and measure a health outcome for mother and/or baby. Authors conducted full-text screening, quality assurance using the AMSTAR tool and data extraction steps in pairs. Narrative analysis of the 22 reviews included show gestational diabetes, pre-eclampsia, gestational hypertension, depression, instrumental and caesarean birth, and surgical site infection to be more likely to occur in pregnant women with obesity compared with women with a healthy weight. Maternal obesity is also linked to greater risk of preterm birth, large-for-gestational-age babies, foetal defects, congenital anomalies and perinatal death. Furthermore, breastfeeding initiation rates are lower and there is greater risk of early breastfeeding cessation in women with obesity compared with healthy weight women. These adverse outcomes may result in longer duration of hospital stay, with concomitant resource implications. It is crucial to reduce the burden of adverse maternal and foetal/child outcomes caused by maternal obesity. Women with obesity need support to lose weight before they conceive, and to minimize their weight gain in pregnancy

Landbrugets Eedstaber og Maskiner 1896.Af Statskonsulent.

Landbrugets Eedstaber og Maskiner 1896.Af Statskonsulent