Atomistic origins of the phase transition mechanism in Ge2Sb2Te5

Combined static and molecular dynamics first-principles calculations are used to identify a direct structural link between the metastable crystalline and amorphous phases of Ge2Sb2Te5. We find that the phase transition is driven by the displacement of Ge atoms along the rocksalt [111] direction from the stable-octahedron to high-energy-unstable tetrahedron sites close to the intrinsic vacancy regions, which give rise to the formation of local 4-fold coordinated motifs. Our analyses suggest that the high figures of merit of Ge2Sb2Te5 are achieved from the optimal combination of intrinsic vacancies provided by Sb2Te3 and the instability of the tetrahedron sites provided by GeTe

Holographic DC conductivities from the open string metric

We study the DC conductivities of various holographic models using the open string metric (OSM), which is an effective metric geometrizing density and electromagnetic field effect. We propose a new way to compute the nonlinear conductivity using OSM. As far as the final conductivity formula is concerned, it is equivalent to the Karch-O'Bannon's real-action method. However, it yields a geometrical insight and technical simplifications. Especially, a real-action condition is interpreted as a regular geometry condition of OSM. As applications of the OSM method, we study several holographic models on the quantum Hall effect and strange metal. By comparing a Lifshitz background and the Light-Cone AdS, we show how an extra parameter can change the temperature scaling behavior of conductivity. Finally we discuss how OSM can be used to study other transport coefficients, such as diffusion constant, and effective temperature induced by the effective world volume horizon.Comment: 33 page

(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.

Calcium is a second messenger which is required for regulation of many cellular processes. However, excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such, selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently, we have identified an effective analogue of resveratrol, (Z)3,4,5,4′-trans-tetramethoxystilbene (TMS) which selectively elevated the intracellular calcium level in gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. TMS exhibited significant inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR were inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum (ER) stress and AMPK activation. Proteomics analysis also further confirmed that mTOR pathway, which is the downstream of AMPK, was significantly suppressed by TMS. JNK, the cross-linker of ER stress and mTOR pathway was significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together, TMS showed promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients

The X-ray emission lines in GRB afterglows: the evidence for the two-component jet model

Recently, X-ray emission lines have been observed in X-ray afterglows of several $\gamma$-ray bursts. It is a major breakthrough for understanding the nature of the progenitors. It is proposed that the X-ray emission lines can be well explained by the Geometry-Dominated models, but in these models the illuminating angle is much larger than that of the collimated jet of the $\gamma$-ray bursts(GRBs). For GRB 011211, we obtain the illuminating angle is about $\theta\sim45^{\circ}$, while the angle of GRB jet is only $3.6^{\circ}$, so we propose that the outflow of the GRBs with emission lines should have two distinct components. The wide component illuminates the reprocessing material, and produces the emission lines, while the narrow one produces the $\gamma$-ray bursts. The observations show that the energy for producing the emission lines is higher than that of the GRBs. In this case, when the wide component dominates the afterglows, a bump will appear in the GRBs afterglows. For GRB 011211, the emergence time of the bump is less than 0.05 days after the GRB, it is obviously too early for the observation to catch it. With the presence of the X-ray emission lines there should also be a bright emission component between the UV and the soft X-rays. These features can be tested by the $Swift$ satellite in the near future.Comment: 10 pags, 1 figure, ChJAA in pres

Entropy Function for Non-Extremal Black Holes in String Theory

We generalize the entropy function formalism to five-dimensional and four-dimensional non-extremal black holes in string theory. In the near horizon limit, these black holes have BTZ metric as part of the spacetime geometry. It is shown that the entropy function formalism also works very well for these non-extremal black holes and it can reproduce the Bekenstein-Hawking entropy of these black holes in ten dimensions and lower dimensions.Comment: 19 pages, no figure, JHEP3 style, to appear in JHE

A Holographic Model of Strange Metals

We give a review on our recent work arXiv:1006.0779 [hep-th] and arXiv:1006.1719 [hep-th], in which properties of holographic strange metals were investigated. The background is chosen to be anisotropic scaling solution in Einstein-Maxwell-Dilaton theory with a Liouville potential. The effects of bulk Maxwell field, an extra U(1) gauge field and probe D-branes on the DC conductivity, the DC Hall conductivity and the AC conductivity are extensively analyzed. We classify behaviors of the conductivities according to the parameter ranges in the bulk theory and characterize conditions when the holographic results can reproduce experimental data.Comment: 34 pages, 15 figures, minor correction

Two-photon Lithography for 3D Magnetic Nanostructure Fabrication

Ferromagnetic materials have been utilised as recording media within data storage devices for many decades. Confinement of the material to a two dimensional plane is a significant bottleneck in achieving ultra-high recording densities and this has led to the proposition of three dimensional (3D) racetrack memories that utilise domain wall propagation along nanowires. However, the fabrication of 3D magnetic nanostructures of complex geometry is highly challenging and not easily achievable with standard lithography techniques. Here, by using a combination of two-photon lithography and electrochemical deposition, we show a new approach to construct 3D magnetic nanostructures of complex geometry. The magnetic properties are found to be intimately related to the 3D geometry of the structure and magnetic imaging experiments provide evidence of domain wall pinning at a 3D nanostructured junction