2-Axis Electric Off-Road Bucket Seat Bases

Off-road vehicle bucket seats are currently restricted to a single position relative to the floor of the vehicle. Drivers and riders desire the ability to adjust their seat position to increase comfort and allow for a greater size range of riders to fit safely within the cabin or roll cage. To develop a viable solution, the team has gone through an extensive design process and has constructed a functioning prototype. This Final Design Report encapsulates the entire design process and concludes with recommendations for changes we would make looking both back in review as well as moving forward with further iterations of the product

Adapting an Analog Records Management System for the Ingest and Accession of Permanent Electronic Records

The Records and Archives Division of the Office of the Missouri Secretary of State (hereafter MSA) received two National Historical Publications and Records Commission (NHPRC) grants for the purpose of establishing an electronic records program at the Missouri State Archives. The first grant covered planning, staff training and a consultant who determined that minor modifications to the current State of Missouri Agency Records Tracking (SMART) System would allow for the ingest of permanent electronic records. The second grant funded the SMART upgrade and the purchase of data-grabbing equipment. The upgrade succeeded and MSA was able to ingest 150 GB of permanent electronic records via the SMART System

Regulation of the levels of health promoting compounds: lupeol, mangiferin and phenolic acids in the pulp and peel of mango fruit: a review

There is a demand for feasible methodologies that can increase/ maintain the levels of health-promoting phytochemicals in horticultural produce, due to strong evidence that these compounds can reduce risk of chronic diseases. Mango (Mangifera indica L.), ranks fifth among the most cultivated fruit crops in the world, is naturally rich in phytochemicals such as lupeol, mangiferin and phenolic acids (eg. gallic acid, chlorogenic acid and vanillic acid). Yet, there is still much scope for up-regulating the levels of these compounds in mango fruit through manipulation of different pre- and postharvest practices that affect their biosynthesis and degradation. The process of ripening, harvest maturity, physical and chemical elicitor treatments such as low temperature stress, methyl jasmonate (MeJA), salicylic acid (SA) and nitric oxide (NO) and the availability of enzyme cofactors (Mg2+ , Mn2+ and Fe2+ ) required in terpenoid biosynthesis were identified as potential determinants of the concentration of health-promoting compounds in mango fruit. The effectiveness of these pre- and postharvest approaches in regulating the levels of lupeol, mangiferin and phenolic acids in the pulp and peel of mango fruit will be discussed. In general spray application of 0.2% FeSO4 30 d before harvest, harvest at sprung stage,storage of mature green fruit at 5 °C for 12 d prior to ripening, fumigation of mature green fruit with 10-5 M and/or 10-4 M MeJA for 24 h or 20 and/or 40 µL L-1 NO for 2 h upregulate the levels of lupeol, mangiferin and phenolic acids in pulp and peel of ripe mango fruit. This article is protected by copyright. All rights reserved

Measuring successful conversations in couples with and without aphasia: A scoping review

Background Aphasia impacts communication and relationships. While counselling is increasingly recognised as a component of the speech‐language therapy role, the success of conversation partner training is typically measured in terms of communication alone. This scoping review aimed to describe how successful conversation is currently measured with couples—with and without aphasia, to inform the development of an ecologically valid measure for couples with aphasia. Methods and Procedures The scoping review was reported in alignment with the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis Extensions for Scoping Reviews (PRISMA‐SCR). MEDLINE, EMBASE, CINAHL and PsycINFO databases were searched for conversation treatment studies for couples with and without aphasia. Patient‐reported outcome measures (PROMs) were extracted from included studies and screened against the three‐tier model of situated language to shortlist those that measure everyday communication. Items within shortlisted PROMs were further described using the refined International Classification of Functioning, Disability and Health linking rules. Results Following screening and full‐text review, 46 studies were included, consisting of 24 studies conducted with couples with aphasia and 22 studies conducted with couples without aphasia. For couples with aphasia, 13 PROMs were identified that measured everyday communication. Of these, 23% were dyadic (i.e., measured from the perspectives of both members of the couple); however, they usually only appraised the communication behaviours of the person with aphasia. For couples without aphasia, eight PROMs were identified that measured everyday communication; all were dyadic and measured both attitudes and communication behaviours of both partners. Conclusion Conversation relies on the interaction of two people, and success in conversation is best rated by those having the conversation. The use of PROMs is recommended as part of person and relationship‐centred practice; however, there is currently no validated PROM for conversation in aphasia that considers the perspectives and behaviours of both the person with aphasia and their communication partner. The PROM items identified in this study will form the basis of future research to develop a PROM for couples' conversations in aphasia. WHAT THIS PAPER ADDS What is already known on the subject Communication partner training (CPT) for couples, where one person has aphasia, can improve conversation skills and enhance relationships. Clinician‐rated measures, such as conversation analysis, have been used to measure the outcomes of CPT. However, there is a lack of person‐centred or self‐rated outcome measurement instruments. that is, patient‐reported outcome measures (PROMs) for couples' conversations in aphasia. What this paper adds to existing knowledge We have identified outcome measurement instruments used in conversation treatment studies for couples with and without aphasia. We found that most PROMs used in aphasia treatment studies were not dyadic, that is, they did not include the self‐report of both communication partners. In contrast, the PROMs used with couples without aphasia were dyadic and contained items that measured a more complex range of both partners' emotions, behaviours and attitudes. What are the potential or actual clinical implications of this work? This study provides insights into the content and characteristics of PROMs for couples' conversation therapy and may assist clinicians in selecting outcome measurement instruments in their practice

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability

Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4, are mutated in human diseases manifesting in premature aging and cancer. We are interested in determining to which extent these RecQ helicases function cooperatively. Here, we report a novel physical and functional interaction between BLM and RECQL4. Both BLM and RECQL4 interact in vivo and in vitro. We have mapped the BLM interacting site to the N-terminus of RECQL4, comprising amino acids 361-478, and the region of BLM encompassing amino acids 1-902 interacts with RECQL4. RECQL4 specifically stimulates BLM helicase activity on DNA fork substrates in vitro. The in vivo interaction between RECQL4 and BLM is enhanced during the S-phase of the cell cycle, and after treatment with ionizing radiation. The retention of RECQL4 at DNA double-strand breaks is shortened in BLM-deficient cells. Further, depletion of RECQL4 in BLM-deficient cells leads to reduced proliferative capacity and an increased frequency of sister chromatid exchanges. Together, our results suggest that BLM and RECQL4 have coordinated activities that promote genome stabilit

The politics of playing along: radio and regulation in democratic Europe

The loss of localism has been a common trend in most radio markets in Europe and the United States. Deregulation of ownership led to a concentration phenomenon that has affected local radios in several western democracies. New forms of regulation have been considered as possible ways to stop the erosion of localism by applying rules to markets in the defense of diversity, pluralism, and the local dimension. This article analyses the local radio market in Portugal, by assessing the changes in the legislation and by examining the regulatory action that can, according to its remit, act preventively to avoid market forces to harm these principles.info:eu-repo/semantics/publishedVersio