The relationship between radio power at 22 and 43 GHz and black hole properties of AGN in elliptical galaxies

We investigate the relationship between radio power and properties related to active galactic nuclei (AGNs). Radio power at 1.4 or 5 GHz, which has been used in many studies, can be affected by synchrotron self-absorption and free-free absorption in a dense region. On the other hand, these absorption effects get smaller at higher frequencies. Thus, we performed simultaneous observations at 22 and 43 GHz using the Korean VLBI Network (KVN) radio telescope based on a sample of 305 AGN candidates residing in elliptical galaxies from the overlap between the Sloan Digital Sky Survey (SDSS) Data Release 7 and Faint Images of the Radio Sky at Twenty-Centimeters (FIRST). About 37% and 22% of the galaxies are detected at 22 and 43 GHz, respectively. Assuming no flux variability between the FIRST and KVN observation, spectral indices were derived from FIRST and KVN data and we found that over 70% of the detected galaxies have flat or inverted spectra, implying the presence of optically thick compact regions near the centres of the galaxies. Core radio power does not show a clear dependence on black hole mass at either low (1.4 GHz) or high (22 and 43 GHz) frequencies. However, we found that the luminosity of the [OIII] $\lambda$5007 emission line and the Eddington ratio correlate with radio power more closely at high frequencies than at low frequencies. This suggests that radio observation at high frequencies can be an appropriate tool for unveiling the innermost region. In addition, the luminosity of the [OIII] $\lambda$5007 emission line and the Eddington ratio can be used as a tracer of AGN activity. Our study suggests a causal connection between high frequency radio power and optical properties of AGNs.Comment: 14 pages, 13 figures, 5 tables, Accepted for publication in A&

Health Concerns and Consumer Preferences for Soy Foods: Choice Modeling Approach

Consumer/Household Economics, Food Consumption/Nutrition/Food Safety,

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular strategies that determine the ultimate choice of DNA repair and survival or apoptotic cell death remain incompletely understood. Here we report that a protein tyrosine phosphatase, EYA, is involved in promoting efficient DNA repair rather than apoptosis in response to genotoxic stress in mammalian embryonic kidney cells by executing a damage-signal-dependent dephosphorylation of an H2AX carboxy-terminal tyrosine phosphate (Y142). This post-translational modification determines the relative recruitment of either DNA repair or pro-apoptotic factors to the tail of serine phosphorylated histone H2AX (gamma-H2AX) and allows it to function as an active determinant of repair/survival versus apoptotic responses to DNA damage, revealing an additional phosphorylation-dependent mechanism that modulates survival/apoptotic decisions during mammalian organogenesis

Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles.

This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo. Here we use this approach to assess in vivo the therapeutic efficacy of the novel chemotherapy construct, HerDox during and after treatment. HerDox is comprised of doxorubicin non-covalently assembled in a viral-like particle targeted to HER2+ tumor cells, causing tumor cell death at over 10-fold lower dose compared to the untargeted drug, while sparing the heart. Whereas our initial proof-of-principle studies on HerDox used tumor growth/shrinkage rates as a measure of therapeutic efficacy, here we show that multimodal imaging deployed during and after treatment can supplement traditional modes of tumor monitoring to further characterize the particle in tissues of treated mice. Specifically, we show here that tumor cell apoptosis elicited by HerDox can be monitored in vivo during treatment using high frequency ultrasound imaging, while in situ confocal imaging of excised tumors shows that HerDox indeed penetrated tumor tissue and can be detected at the subcellular level, including in the nucleus, via Dox fluorescence. In addition, ratiometric spectral imaging of the same tumor tissue enables quantitative discrimination of HerDox fluorescence from autofluorescence in situ. In contrast to standard approaches of preclinical assessment, this new method provides multiple/complementary information that may shorten the time required for initial evaluation of in vivo efficacy, thus potentially reducing the time and cost for translating new drug molecules into the clinic

Characterisation of Bidor Kaolinite and Illite

Two types of commercial clay minerals from the Bidor region of Perak were studied. From the X-ray diffraction study, these clays were identified as disordered kaolinite and 2 M polymorph of illite. The morphologies, the surface properties, the pore structures and the infrared absorption properties were examined. The basis for the identification of these clays is discussed