Kartlegging av forurensningstilstanden i Meråker gruvefelt

Avrenning fra kisgruvene i Meråkerfeltet påvirker fortsatt vannkvaliteten i vassdragene i nedbørfeltet selv 100 år etter at gruvedriften opphørte. Største forurensningskilde i området er Lillefjell gruve som bidrar med ca. 80 % av kobbertilførslene til Stjørdalselva som er ca. 3 tonn på årsbasis. Gilsåa og Dalåa er mest belastet med tungmetaller, men vassdragsreguleringen som er foretatt, kan ha bidratt til en forverret vannkvalitet i Torsbjørka nedenfor inntaket til kraftverket. Undersøkelser av bunnfaunaen viser klare påvirkninger i Dalåa, mens det var en naturlig bunnfauna i nedre del av Torsbjørka og i Stjørdalselva. Burforsøk med ørret viste en høy dødelighet i Gilsåa/Dalåa. Det ble også påvist at ørreten i Torsbjørka var metallbelastet

Composition and biological significance of the human Nα-terminal acetyltransferases

Protein Nα-terminal acetylation is one of the most common protein modifications in eukaryotic cells, occurring on approximately 80% of soluble human proteins. An increasing number of studies links Nα-terminal acetylation to cell differentiation, cell cycle, cell survival, and cancer. Thus, Nα-terminal acetylation is an essential modification for normal cell function in humans. Still, little is known about the functional role of Nα-terminal acetylation. Recently, the three major human N-acetyltransferase complexes, hNatA, hNatB and hNatC, were identified and characterized. We here summarize the identified N-terminal acetyltransferase complexes in humans, and we review the biological studies on Nα-terminal acetylation in humans and other higher eukaryotes

Current state of the art and use case description on geofencing for traffic management

This report is a result of a literature review and document gathering focused on geofence use cases specific for road traffic management. It presents geofence use cases that are trialled or to be trialled, implemented use cases, as well as conceptual and potential future use cases, showing for which type of transport they are used and how geofence zones are applied or to be applied. The report was conducted in the project GeoSence – Geofencing strategies for implementation in urban traffic management and planning. It is a Joint programme initiative (JPI) Urban Europe project funded by European Union´s Horizon 2020, under ERA-NET Cofund Urban Accessibility and Connectivity and gather project partners from Germany, Norway, Sweden and UK. The goal is to present the current state of art, and describe use cases, based on the working definition of geofencing in the project, where geofence is defined as a virtual geographically located boundary, statically or dynamically defined. The study shows that for implemented and real-traffic trial use case, geofencing has been applied within private car transport, shared micro-mobility, freight and logistics, public bus transportation and ridesourcing. For the future use cases, geofencing has been tested or conceptually developed also for automated vehicles and shared automated mobility, among others. The report summarises main use cases and find them to answering to especially four challenges in traffic management: safety, environment, efficiency, and tracking and data collection. Some of the use cases however answer to several of these challenges, such as differentiated road charging, and the use cases in micro-mobility. Further, the system and functionality of the trialled and/or implemented use cases, show different types of regulation geofence use cases can be used for, from informing, assisting, full enforcement, incentivising and penalisation. Guidelines and recommendations so far form national authorities show that the existence of joint regulation or guidelines for the use of geofencing for different use cases is low – with some exceptions. Digital representation of traffic regulation will be crucial for enabling geofencing

Beyond the myth of legality? Framing effects and public reactions to high court decisions in Europe

How do people respond to different decision-making processes in high courts? One long-standing view suggests that citizens expect courts to be neutral arbiters of legal controversies. Although the relevance of such “myth of legality” has been challenged, we know very little about the relationship between the portrayals of the motives of courts and justices and public attitudes in civil law countries. We explore this question in a pair of experiments in Norway and Portugal where we isolate the effects of different institutional frames from outcome favorability. We find that while partisan frames are detrimental to fairness perceptions and acceptance of decisions, depictions of judicial decision-making that emphasize policy goals do not adversely affect citizens’ responses in comparison with legalistic frames. The results suggest that, even in civil law systems, preserving the myth of legality may not be a necessary condition to elicit public support for judicial decisions

Teleportation via thermally entangled state of a two-qubit Heisenberg XX chain

We find that quantum teleportation, using the thermally entangled state of two-qubit Heisenberg XX chain as a resource, with fidelity better than any classical communication protocol is possible. However, a thermal state with a greater amount of thermal entanglement does not necessarily yield better fidelity. It depends on the amount of mixing between the separable state and maximally entangled state in the spectra of the two-qubit Heisenberg XX model.Comment: 5 pages, 1 tabl

Sink i ferskvann - kjemi, tilførsler og biologiske effekter

Det er laget en kunnskapsstatus for betydningen av sink i ferskvann med særlig vekt på tilførsler fra gruveavrenning. I tillegg ble det utført en undersøkelse av biologiske effekter i et vassdrag. Sveselva, med sink-belastning, men få andre metaller. Alle levende organismer har behov for sink, men det er begrensede kunnskaper om mekanismene bak giftigheten til metallet. Effekt-grenser for akvatiske organismer varier fra 10 til over 1000 µg/l. Blant de mest følsomme organismene er enkelte alger, planktoniske krepsdyr og utviklingsstadier hos fisk. I Sveselva var det tilsynelatende effekter på vegetasjon (begroing) allerede ved 20-30 µg/l, men det er usikkert om dette var det reelle belastningsnivået. Både vegetasjon og bunndyr var klart påvirket på stasjoner med konsentrasjoner i området 250-670 µg/l. Kadmium og sink akkumulerte i gjellene til utplassert dammusling på alle stasjoner nedenfor tilførslene og førte til noe forhøyede konsentrasjoner av metallotionein. Dammusling med høye metall-nivåer i gjellene filtrerte mindre alger og hadde høyere respirasjon enn dammusling med lavere metall-nivåer i gjellene. Resultatene viser at det er viktig å benytte flere mål for biologiske effekter i overvåking av effektene av metall-forurensning og å integrere kjemisk og biologisk overvåking

Thermal and ground-state entanglement in Heisenberg XX qubit rings

We study the entanglement of thermal and ground states in Heisernberg $XX$ qubit rings with a magnetic field. A general result is found that for even-number rings pairwise entanglement between nearest-neighbor qubits is independent on both the sign of exchange interaction constants and the sign of magnetic fields. As an example we study the entanglement in the four-qubit model and find that the ground state of this model without magnetic fields is shown to be a four-body maximally entangled state measured by the $N$-tangle.Comment: Four pages and one figure, small change

Protein N-terminal acetylation: NAT 2007–2008 Symposia

Protein N-terminal acetylation is a very common modification, but has during the past decades received relatively little attention. In order to put this neglected field back on the scientific map, we have in May 2007 and September 2008 arranged two international NAT symposia in Bergen, Norway. This supplement contains selected proceedings from these symposia reflecting the current status of the field, including an overview of protein N-terminal acetylation in yeast and humans, a novel nomenclature system for the N-terminal acetyltransferases (NATs) and methods for studying protein N-terminal acetylation in vitro and in vivo

Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death

Incidence of venous thromboembolism (VTE) risk varies by age and sex. Some studies have reported overall higher risk in men, especially when VTEs triggered by female reproductive factors are excluded. However, higher mortality rates in men may have led to overestimation of lifetime VTE risk in men compared with women. Therefore, we estimated the lifetime risk of VTE in men and women in a Danish, nationwide cohort, taking into account the competing risk of death. Within the population of Denmark (> 5 million persons), all first-time VTEs occurring in 1995–2016 were identified from the Danish National Patient Registry covering all Danish hospitals. The cumulative incidences of VTE were estimated in men and women with age as timescale, taking into account the competing risk of death. Estimated lifetime risk was defined as cumulative incidence at age 100. In a simulation study, we excluded the proportion of female cases that could be attributed to reproductive risk factors and re-estimated the cumulative incidence. We identified 123,543 incident VTEs. The cumulative incidence of VTE was 1.9% in women and 1.3% in men at age 50, 4.3% in women and 4.4% in men at age 70, and 9.3% in women and 8.1% in men at age 100. After accounting for VTEs attributed to reproductive factors, the corresponding incidences in women were 1.2% at age 50, 3.2% at age 70, and 8.2% at age 100. In conclusion, the estimated lifetime risk of VTE was slightly higher in women than in men when accounting for competing risk of death. Our simulation study suggested that reproductive risk factors contribute modestly to the estimated lifetime VTE risk in women

A novel human NatA Nα-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)

<p>Abstract</p> <p>Background</p> <p>Protein acetylation is among the most common protein modifications. The two major types are post-translational N^ε-lysine acetylation catalyzed by KATs (Lysine acetyltransferases, previously named HATs (histone acetyltransferases) and co-translational N^α-terminal acetylation catalyzed by NATs (N-terminal acetyltransferases). The major NAT complex in yeast, NatA, is composed of the catalytic subunit Naa10p (<b>N a</b>lpha <b>a</b>cetyltransferase <b>10 p</b>rotein) (Ard1p) and the auxiliary subunit Naa15p (Nat1p). The NatA complex potentially acetylates Ser-, Ala-, Thr-, Gly-, Val- and Cys- N-termini after Met-cleavage. In humans, the homologues hNaa15p (hNat1) and hNaa10p (hArd1) were demonstrated to form a stable ribosome associated NAT complex acetylating NatA type N-termini <it>in vitro </it>and <it>in vivo</it>.</p> <p>Results</p> <p>We here describe a novel human protein, hNaa16p (hNat2), with 70% sequence identity to hNaa15p (hNat1). The gene encoding hNaa16p originates from an early vertebrate duplication event from the common ancestor of h<it>NAA15 </it>and h<it>NAA16</it>. Immunoprecipitation coupled to mass spectrometry identified both endogenous hNaa15p and hNaa16p as distinct interaction partners of hNaa10p in HEK293 cells, thus demonstrating the presence of both hNaa15p-hNaa10p and hNaa16p-hNaa10p complexes. The hNaa16p-hNaa10p complex acetylates NatA type N-termini <it>in vitro</it>. hNaa16p is ribosome associated, supporting its potential role in cotranslational N^α-terminal acetylation. h<it>NAA16 </it>is expressed in a variety of human cell lines, but is generally less abundant as compared to h<it>NAA15</it>. Specific knockdown of h<it>NAA16 </it>induces cell death, suggesting an essential role for hNaa16p in human cells.</p> <p>Conclusion</p> <p>At least two distinct NatA protein N^α-terminal acetyltransferases coexist in human cells potentially creating a more complex and flexible system for N^α-terminal acetylation as compared to lower eukaryotes.</p