Phytochemical Screening and in Vitro Antioxidant Activity of Parkia biglobosa Extract

Parkia biglobosa leaves have popular folkloric ethnomedicinal use in the treatment of many diseases especially among the South-Western people of Nigeria. The present study was undertaken to find the antioxidant value of aqeous-methanolic extract of Parkia biglobosa leaf by investigating its phytochemicals and invitro antioxidant potentials. Antioxidant activity of extract was screened for by measuring its total flavonoid and total phenol content, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and ferric reducing property. Phytochemical screening was carried out on extract by standard method. Phytochemical analyses revealed the presence of saponins, flavonoids, tannins and cardiac glycosides. The total phenol and flavonoid contents are 144.18 mg gallic acid equivalent/g extract and 256.858mg Quercetin equivalent/g extract respectively. The extract showed considerably high and dose-dependent DPPH radical scavenging and ferric reducing property comparable with the respective standards, Quercetin and Ascorbic acid. The results of this study reveal that Parkia biglobosa leaf extract possess significant antioxidant properties and could be exploited as source of antioxidant additives. Keywords: Parkia biglobosa, phytochemicals, Antioxidant activit

DEVELOPMENT OF A CLOUD BASED STUDENT INFORMATION CHATBOT SYSTEM

The development of chatbot system is an algorithm that analyzes the student queries and reply messages. In this system, artificial intelligence is built to answer the query of the student. The specific objectives are to determine the required features for the construction of knowledge base, design and implement the model, evaluate the performance of the developed system. Samples of Frequently Asked Questions (FAQ) was collected from the department of Student Affairs, Admission Office and Information Management and Technology Center (IMTC) of the university. The collected sample was analyzed based on the category of question and the model was designed using Unified Modeling Language (UML). The model was implemented with python programming language, HTML, CSS, JavaScript for the client sever side, and also Artificial Intelligence Markup Language (AIML) () and MySQL for the back end. The developed system performance was evaluated using Alpha Beta testing. The proposed system was successfully tested to denote its effectiveness and achievability. It totally eliminates the manual process of retrieving information about a particular domain and reduces manpower, time, for any individual. The developed system will provide adequate assistance to the student on FAQ, thereby reducing the time in visiting the college to enquire about the information in respect of school activities. It will also provide an enabling environment for the students to keep them updated about the school activities

Gestational trophoblastic disease in Abuth Zaria, Nigeria: A 5‑year review

Gestational trophoblastic diseases (GTD) includes a spectrum of diseases (tumor or tumor-like conditions) characterised by aberrant growth and development of the trophoblasts that may continue even beyond the end of pregnancy. It encompasses the benign trophoblastic disease (complete and partial moles), and the malignant trophoblastic diseases including the invasive mole (chorioadenoma destruens), choriocarcinoma, and Placental Site Trophoblastic Tumor (PSTT). This study was to determine the prevalence, risk factors, clinical presentation, diagnosis, treatment options and outcomes of GTD in Ahmadu Bello University Teaching Hospital (ABUTH) Zaria. A five-year retrospective study of patients with GTD managed at ABUTH, North-west Nigeria, from 1st January 2008 to 31st December, 2012 was undertaken. Data of all cases of GTD in the hospital over the 5 year period were obtained. The gynaecology ward and labour ward registers also provided information on the total number of gynaecological admissions and deliveries respectively. The data processing and analysis were carried out using the SPSS software version 16. The data obtained were expressed in percentages, means, and standard deviations. During the period of study there were 8,138 deliveries and 2,453 gynaecological admissions. There were 59 cases of GTD with 41 having choriocarcinoma, 18 molar pregnancies and no case of invasive mole or PSTT. Out of the 41 case folders retrieved, 23 were choriocarcinoma and 18 of molar pregnancies. The prevalence of GTD was 7.2 per 1000 deliveries (0.72% or 1 in 138 deliveries) and constituted 2.4% of gynaecological admissions. Hydatidiform mole (HM) occurred in 1 in 452 deliveries and choriocarcinoma occurred in 1 in 198 deliveries. Ages ranged from 19-49 years with mean of 32.5+ 5.0 years. Most (66.7%) cases of HM were 19-29years while 60.9% of choriocarcinoma cases were 30-39years. Majority of cases were multiparous. The antecedent events predating choriocarcinoma were Hydatidiform mole (31.7%), abortions (29.3%) and 2.4% followed term pregnancy. History of amenorrhea was present in all cases while vaginal bleeding occurred in 97.6%, pallor (87.8%), hyperemesis gravidarum (48.8%) and 4.9% came in shock. Consequently, common complications reported were haemorrhage (90.2%), anemia (87.8%) and shock (12.2%). Pregnancy test was positive in 90.2% of cases and serum beta hCG was done in 24.4% with more than half having a level >12,000miu/ml. All patients had pelvic ultrasound scan and snowstorm appearance occurred in 41% of benign GTD cases. Histology was used to confirm 56.1% cases of choriocarcinoma and 43.9% of molar gestation. Most (94.4%) of HM had suction evacuation while 95.6% of choriocarcinoma cases had chemotherapy, one case (2.4%) had Total Abdominal Hysterectomy. Contraception was used in 78% and common methods were male condom (41.5%) and 36.6% used combined oral contraceptive pills. Less than half (43.9%) had follow up for 6 months and 9.8% were seen for more than a year. Eight patients had subsequent pregnancies and there was one death in the series giving a case fatality of 2.4%. Gestational trophoblastic disease is a significant source of maternal morbidity with increased risk of mortality from complications if not detected early and treated promptly.Keywords: Choriocarcinoma; gestational trophoblastic disease; human chorionic gonadotrophin; hydatidiform mole; placental site trophoblastic diseas

Typhoid and Paratyphoid Cost of Illness in Pakistan: Patient and Health Facility Costs from the Surveillance for Enteric Fever in Asia Project II

Background: The objective of this study was to estimate the cost of illness from enteric fever (typhoid and paratyphoid) at selected sites in Pakistan. Methods: We implemented a cost-of-illness study in 4 hospitals as part of the Surveillance for Enteric Fever in Asia Project (SEAP) II in Pakistan. From the patient and caregiver perspective, we collected direct medical, nonmedical, and indirect costs per case of enteric fever incurred since illness onset by phone after enrollment and 6 weeks later. From the health care provider perspective, we collected data on quantities and prices of resources used at 3 of the hospitals, to estimate the direct medical economic costs to treat a case of enteric fever. We collected costs in Pakistani rupees and converted them into 2018 US dollars. We multiplied the unit cost per procedure by the frequency of procedures in the surveillance case cohort to calculate the average cost per case. Results: We collected patient and caregiver information for 1029 patients with blood culture-confirmed enteric fever or with a nontraumatic terminal ileal perforation, with a median cost of illness per case of US $196.37 (IQR, US$72.89-496.40). The median direct medical and nonmedical costs represented 8.2% of the annual labor income. From the health care provider perspective, the estimated average direct medical cost per case was US $50.88 at Hospital A, US$52.24 at Hospital B, and US $11.73 at Hospital C. Conclusions: Enteric fever can impose a considerable economic burden in Pakistan. These new estimates of the cost of illness of enteric fever can improve evaluation and modeling of the costs and benefits of enteric fever prevention and control measures, including typhoid conjugate vaccines

STUDIES ON THE ANTIBACTERIAL AND ANTICORROSIVE PROPERTIES OF SYNTHESIZED HYBRID POLYURETHANE COMPOSITES FROM CASTOR SEED OIL

Castor seed oil (Ricinus communis) is a prominent feed stock towards the generation of renewable materials for industrial production. The reach presence of ricinoleic fatty acid at 87.5% provides pendant hydroxyl functional groups, which is an essential site for chemical formulations. This paper presents the synthesis, characterization, and evaluations on antibacterial and anticorrosive activities of synthesized hybrid composites from Ricinus communis seed oil. N,N'-bis(2-hydroxy ethyl)-12-hydroxy Ricinus communis oil fatty amide (HERCA) was synthesized via aminolysis polyol formation route. Upon reacting HERCA with succinic acid at a high temperature of about 145 ºC, a polyesteramide (RCPEA) was formed. This ester product undergoes urethanation and subsequently interfaced with modified hybrid material. The synthesized composites were characterized using spectroscopic methods such as FTIR, 1H-NMR, and 13C-NMR. Selected physicochemical parameters were also carried out on the products. Coating performance on cured resins was examined

OPTIMIZATION PRINCIPLE AND ITS’ APPLICATION IN OPTIMIZINGLANDMARK UNIVERSITY BAKERY PRODUCTION USING LINEAR PROGRAMMING

This paper deals with the applications ofoptimization principle in optimizing profits of a production industry using linear programming to examine the production cost and determine its optimal profit. Linear programming is an operation research technique which is widely used in finding solutionsto managerial decision problems. However, many enterprises make more use of the trial-and-error method. As such, firms have been finding it difficult in allocating scarce resources in a manner that will ensure profit maximization and/or cost minimization.This paper makse use of secondary data collected from the records of the Landmark University Bakery on five types of bread produced in the firm which include Family loaf, sliced family bread, Chocolate loaf, medium size bread, small size bread. A problemof this nature was identified as a linear programming problem, formulated in Mathematical terms and solved using AMPL software. The solution obtained revealed that Landmark bakery unit should concentrate much more in production of 14,000 loaves of Family loaf and 10,571 loaves of Chocolate bread while others type should be less produced since their value is turning to zero in order to achieve a maximum monthly profit ofN1,860,000. From the analysis, it was observed that Family loaf and the Chocolate breadcontributed objectively to the profit. Hence, more of Family loaf and Chocolate bread are needed to be produced and sold in order to maximize the profi

Studies on the Antibacterial and Anticorrosive Properties of Synthesized Hybrid Polyurethane composites from Castor Seed Oil

Castor seed oil (Ricinus communis) is a prominent feed stock towards the generation of renewable materials for industrial production. The reach presence of ricinoleic fatty acid at 87.5% provides pendant hydroxyl functional groups, which is an essential site for chemical formulations. This paper presents the synthesis, characterization, and evaluations on antibacterial and anticorrosive activities of synthesized hybrid composites from Ricinus communis seed oil. N,N'-bis(2-hydroxy ethyl)-12-hydroxy Ricinus communis oil fatty amide (HERCA) was synthesized via aminolysis polyol formation route. Upon reacting HERCA with succinic acid at a high temperature of about 145 oC, a polyesteramide (RCPEA) was formed. This ester product undergoes urethanation and subsequently interfaced with modified hybrid material. The synthesized composites were characterized using spectroscopic methods such as FT- IR, 1H-NMR, and 13C-NMR. Selected physicochemical parameters were also carried out on the products. Coating performance on cured resins was examined