Gender and uveitis in patients with multiple sclerosis.

Multiple sclerosis (MS), a demyelinating disease of the central nervous system, is more commonly seen in women. It has been associated with both anterior and intermediate uveitis as well as retinal vasculitis. Ocular inflammation may develop concurrent with, prior to, or after the development of neurologic signs and symptoms. Patients with MS have an approximately 1% chance of developing intraocular inflammation. Patients with intermediate uveitis have an 8-12% risk of being diagnosed with MS. This risk is higher in females and in those with bilateral disease. This should be kept in mind when evaluating patients with uveitis, particularly in those patients for whom TNF inhibitor therapy is being considered, as these agents may worsen demyelinating disease

Automatic data processing for photographic photometry in spectrographic analysis

Automatic data processing for photographic photometry in spectrographic analysi

Development of an Advanced Force Field for Water using Variational Energy Decomposition Analysis

Given the piecewise approach to modeling intermolecular interactions for force fields, they can be difficult to parameterize since they are fit to data like total energies that only indirectly connect to their separable functional forms. Furthermore, by neglecting certain types of molecular interactions such as charge penetration and charge transfer, most classical force fields must rely on, but do not always demonstrate, how cancellation of errors occurs among the remaining molecular interactions accounted for such as exchange repulsion, electrostatics, and polarization. In this work we present the first generation of the (many-body) MB-UCB force field that explicitly accounts for the decomposed molecular interactions commensurate with a variational energy decomposition analysis, including charge transfer, with force field design choices that reduce the computational expense of the MB-UCB potential while remaining accurate. We optimize parameters using only single water molecule and water cluster data up through pentamers, with no fitting to condensed phase data, and we demonstrate that high accuracy is maintained when the force field is subsequently validated against conformational energies of larger water cluster data sets, radial distribution functions of the liquid phase, and the temperature dependence of thermodynamic and transport water properties. We conclude that MB-UCB is comparable in performance to MB-Pol, but is less expensive and more transferable by eliminating the need to represent short-ranged interactions through large parameter fits to high order polynomials

Rapid characterization of the ultraviolet induced fiber Bragg grating complex coupling coefficient as a function of irradiance and exposure time

We report the application of optical frequency domain reflectometry and a discrete-layer-peeling inverse scattering algorithm to the spatial characterization of the UV induced complex coupling coefficient during fiber Bragg grating growth. The fiber grating is rapidly characterized using this technique to give irradiance dependent growth as a function of exposure time, thereby providing the complete characterization of the coupling coefficient in the form of a "growth surface," which is related to the fiber's photosensitivity. We compare measurements of fiber Bragg grating growth in SMF-28 when exposed to continuous wave 244 nm irradiation from 0 to 90 W cm(-2) for exposure times up to 3230 s with a selection of other fibers including high germanium concentration fiber and erbium doped fiber. (c) 2007 Optical Society of America

Measuring Extinction Curves of Lensing Galaxies

We critique the method of constructing extinction curves of lensing galaxies using multiply imaged QSOs. If one of the two QSO images is lightly reddened or if the dust along both sightlines has the same properties then the method works well and produces an extinction curve for the lensing galaxy. These cases are likely rare and hard to confirm. However, if the dust along each sightline has different properties then the resulting curve is no longer a measurement of extinction. Instead, it is a measurement of the difference between two extinction curves. This "lens difference curve'' does contain information about the dust properties, but extracting a meaningful extinction curve is not possible without additional, currently unknown information. As a quantitative example, we show that the combination of two Cardelli, Clayton, & Mathis (CCM) type extinction curves having different values of R(V) will produce a CCM extinction curve with a value of R(V) which is dependent on the individual R(V) values and the ratio of V band extinctions. The resulting lens difference curve is not an average of the dust along the two sightlines. We find that lens difference curves with any value of R(V), even negative values, can be produced by a combination of two reddened sightlines with different CCM extinction curves with R(V) values consistent with Milky Way dust (2.1 < R(V) < 5.6). This may explain extreme values of R(V) inferred by this method in previous studies. But lens difference curves with more normal values of R(V) are just as likely to be composed of two dust extinction curves with R(V) values different than that of the lens difference curve. While it is not possible to determine the individual extinction curves making up a lens difference curve, there is information about a galaxy's dust contained in the lens difference curves.Comment: 15 pages, 4 figues, ApJ in pres