Hypericum sp.: essential oil composition and biological activities

Phytochemical composition of Hypericum genus has been investigated for many years. In the recent past, studies on the essential oils (EO) of this genus have been progressing and many of them have reported interesting biological activities. Variations in the EO composition of Hypericum species influenced by seasonal variation, geographic distribution, phenological cycle and type of the organ in which EO are produced and/or accumulated have also been reported. Although many reviews attributed to the characterization as well as biological activities of H. perforatum crude extracts have been published, no review has been published on the EO composition and biological activities of Hypericum species until recently (Crockett in Nat Prod Commun 5(9):1493–1506, 2010; Bertoli et al. in Global Sci Books 5:29–47, 2011). In this article, we summarize and update information regarding the composition and biological activities of Hypericum species EO. Based on experimental work carried out in our laboratory we also mention possible biotechnology approaches envisaging EO improvement of some species of the genus.Fundação para a Ciência e a Tecnologia (FCT) - project PTDC/AGR AAM/70418/2006, SFRH/BD/ 13283/2003

Reliability of SleepStrip as a screening test in obstructive sleep apnea patients

Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder and related to multiple conditions that cause mortality in adults. In the present study, reliability of SleepStrip, a disposable screening device for detection of OSAS, is tested. In this prospective, nonrandomized double-blinded single cohort study at an academic health center, the performance of the SleepStrip in detecting respiratory events and establishing an SleepStrip score (Sscore) in domestic use were compared to the apnea-hypopnea index (AHI) obtained by the standard polysomnography (PSG) recordings in the sleep laboratory. Forty-one patients who have the PSG results participated the study and wore the SleepStrips at home. Test efficiency rate was 75% and there was a positive correlation between PSG-AHI scores and Sscores (r = 0.71, p 30 levels. The SleepStrip has 100% specificity and positive predictive values, but it also has low negative predictive and sensitivity values. The SleepStrip is not a reliable screening test in differential diagnosis among simple snorers, mild, moderate and severe OSAS patients. However, high Sscores highly indicate the presence of moderate-severe OSAS. We can safely send these patients to split-night PSG and continuous, automatic, bi-level positive airway pressure (CPAP/BPAP/APAP) titration at the same night. The SleepStrip may increase the effective use of the sleep laboratories

Determination of Phytochemical Contents of Avena sativa (oat) and Its Impact on Debaryomyces hansenii.

In the present study fatty acids, vitamins, phytosterol, flavonoid and resveratrol contents and antimicrobial activities of Avena sativa (oat) extracts treated with Debaryomyces hansenii were determined and compared. Avena sativa is consumed as the fibrous food worldwide. It was shown that total fatty acids and vitamin contents increased significantly in A. sativa extracts prepared with D. hansenii. However, the flavonoid contents decreased at different rates. It was also observed that quercetin and flavonoids were present in the extracts that contained D. hansenii. It was noted that A. sativa had changing rates of antioxidants and antimicrobial activities. Thus, it was concluded that A. sativa has an important place in a healthy lifestyle and oats have positive effect on the development of D. hansenii which is also accepted as a probiotic microorganism. This yeast developed in extracts obtained from this fibrous plant and affected the bioactive compounds at changing rates.FUBAP190