Inkdots as advice for finite automata

We examine inkdots placed on the input string as a way of providing advice to finite automata, and establish the relations between this model and the previously studied models of advised finite automata. The existence of an infinite hierarchy of classes of languages that can be recognized with the help of increasing numbers of inkdots as advice is shown. The effects of different forms of advice on the succinctness of the advised machines are examined. We also study randomly placed inkdots as advice to probabilistic finite automata, and demonstrate the superiority of this model over its deterministic version. Even very slowly growing amounts of space can become a resource of meaningful use if the underlying advised model is extended with access to secondary memory, while it is famously known that such small amounts of space are not useful for unadvised one-way Turing machines.Comment: 14 page

Researching Of Ranking Handball Referees' Job Satisfaction Levels In Terms Of Some Parameters,

This research has been conducted in order to determine the job satisfaction levels of the ranking referees in terms of some parameters (sex, age, marital status, income states, other profession, and refereeing period). This research is a descriptive study towards the review of job satisfaction levels of Handball ranking referees. Referees take charge in 2010-11 season in Turkish leagues constitute the population of the research. Accordingly 107 Ranking referees under Turkish Handball Federation constitute the sample of the research. SPSS package program was used for the statistical analyses. Measuring tool is constituted of two sections. In first section a test directed towards to determine the demographical features of the referees while in second section “Minnesota job satisfaction scale” was used. Validity and reliability studies were made (cronbach alpha =0.70). It was determined that statistically there is not a significant gap between the job satisfaction levels of the referees according to their sex, marital status, ranking position, refereeing periods and income status; and statistically there is a significant gap between their job satisfaction levels according to their ages. Increase of job satisfaction with the increase of age, increase of the experience, awards, rise of refereeing ranking and coalescence with the job are considered to be the factors for the existence of such difference. Income levels of the majority of the referees are seen to be at intermediate level

Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell lymphomas (n=43) and their cell lines (n=9) through next generation and/or Sanger sequencing. STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas. STAT3 and STAT5B mutations are associated with increased phosphorylated protein and a growth advantage to transduced cell lines or normal NK cells. Growth-promoting activity of the mutants can be partially inhibited by a JAK1/2 inhibitor. Molecular modelling and surface plasmon resonance measurements of the N642H mutant indicate a marked increase in binding affinity of the phosphotyrosine-Y699 with the mutant histidine. This is associated with the prolonged persistence of the mutant phosphoSTAT5B and marked increase of binding to target sites. Our findings suggest that JAK-STAT pathway inhibition may represent a therapeutic strategy. © 2015 Macmillan Publishers Limited. All rights reserved

An alternative application to the portuguese agro-industrial residue : wheat straw

The effects of alkaline treatments of the wheat straw with sodium hydroxide were investigated. The optimal condition for extraction of hemicelluloses was found to be with 0.50 mol/l sodium hydroxide at 55 °C for 2 h. This resulted in the release of 17.3% of hemicellulose (% dry starting material), corresponding to the dissolution of 49.3% of the original hemicellulose. The yields were determined by gravimetric analysis and expressed as a proportion of the starting material. Chemical composition and physico-chemical properties of the samples of hemicelluloses were elucidated by a combination of sugar analyses, Fourier transform infrared (FTIR), and thermal analysis. The results showed that the treatments were very effective on the extraction of hemicelluloses from wheat straw and that the extraction intensity (expressed in terms of alkali concentration) had a great influence on the yield and chemical features of the hemicelluloses. The FTIR analysis revealed typical signal pattern for the hemicellulosic fraction in the 1,200–1,000 cm−1 region. Bands between 1,166 and 1,000 cm−1 are typical of xylans.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo a Pesquisa do Estado de São Paulo/Brazil (FAPESP)Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BPD/26156/2005, SFRH/BPD/26108/200

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic