194 research outputs found
Vörös és fekete, avagy a „(re-)konstruált párttörténet" (könyvismertető)
A recenzált mű: Az intézményes forradalom. Adatok a kommunista párt kulturális és társadalmi történetéhez Borsod-Abaúj-Zemplén megyében (1945–1956). Szerk.: KENDE Tamás. Magyar Nemzeti Levéltár Borsod-Abaúj-Zemplén Megyei Levéltára, Miskolc–Budapest, 2014
Centrum és periféria a történetírásban, avagy hol helyezkedett el a Párttörténeti Intézet folyóirata
European studies: Taking stock and looking ahead
This essay is an attempt to generalize experiences of Central and Eastern European universities in the field of European Studies over the past 20 years. The paper follows the logic of business analysis in order to come up with proposals for future action
And the first shall be the last
This study analyzes the puzzle of Hungarian economic drifting in a long run perspective. The underlying puzzle for the investigation is why bad policies are invariably popular and good policies unpopular, thus why political and economic rationality never overlap. The first part of the article summarizes in eight points the basic features of the postwar period. Then six lessons are offered, which might be useful for other countries in transition or for students of comparative economics and politics, lessons that can be generalized on the basis of the individual country experience
dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements
dUTPases ubiquitously regulate cellular dUTP levels to preserve
genome integrity. Recently, several other cellular processes were
reported to be controlled by dUTPases including the horizontal
transfer of Staphylococcus aureus pathogenicity islands (SaPI).
SaPIs are mobil genetic elements that encode virulence enhancing
factors e.g. toxins. Here, phage dUTPases were proposed to
counteract the repressor protein (Stl) and promote SaPI excision
and transfer. A G protein-like mechanism was proposed which is
unexpected in light of the kinetic mechanism of dUTPase.
Here we investigate the molecular mechanism of SaPI transfer
regulation, using numerous dUTPase variants and a wide range
of in vitro methods (steady-state and transient kinetics, VIS and
fluorescence spectroscopy, EMSA, quartz crystal microbalance,
X-ray crystallography).
Our results unambiguously show that Stl inhibits the enzymatic
activity of dUTPase in the nM concentration range and
dUTP strongly inhibits the dUTPase: Stl complexation. These
results identify Stl as a highly potent dUTPase inhibitor protein
and disprove the G protein-like mechanism. Importantly, our
results clearly show that the dUTPase:dUTP complex is inaccessible
to the Stl repressor. Unlike in small GTPases, hydrolysis of
the substrate nucleoside triphosphate (dUTP in this case) is
required prior to the interaction with the partner (Stl repressor in
this case). We propose that dUTPase can efficiently interact with
Stl and induce SaPI excision only if the cellular dUTP level is low (i.e. when dUTPase resides mainly in the apo enzyme form)
while high dUTP levels would inhibit SaPI transfer. This mechanism
may serve the preservation of the integrity of the transferred
SaPI genes and links the well-known metabolic role of
dUTPases to their newly revealed regulatory function in spread
of virulence factors
Több-billentyűs redoműtét felnőtt betegen komplex pulmonalis atresiában
Absztrakt:
A 30 éves, komplex pulmonalis atresiás betegnél csecsemőkorban az unifokalizálás
eldönthetősége miatt exploratio, 10 éves korban rekonstrukciós műtét (kamrai
sövényhiány zárása, unifokalizáció, jobb kamra–arteria pulmonalis
folytonosságának kialakítása homografttal) történt. A mindkét kamra csökkent
működését okozó aortabillentyű-elégtelenség és ascendenstágulat, illetve
homograftelégtelenség miatt az aortabillentyű plasztikája, a pulmonalis
billentyű, illetve az aorta ascendens és arteria pulmonalis törzs cseréje vált
szükségessé. Magyarországon betegünk az első, akinél ilyen redoműtét történt. A
műtét sikere igazolja, hogy megfelelő gondozás, diagnosztika (echokardiográfia,
MR, CT) mellett az időben történt műtét jó korai és késői eredményt biztosíthat
a komplex szívhibás, felnőttkorú betegek számára. Orv. Hetil., 2017,
158(14), 546–549.
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Abstract:
30-year-old adult with complex pulmonary atresia (previous surgical procedures:
in infancy: exploration, at age of 10: ventricular septal defect closing,
unifocalization, homograft implantation between right ventricular outflow tract
and pulmonary artery) has biventricular dysfunction because of aortic valve
regurgitation, ascending aortic aneurysm, and homograft insufficienty.
Multivalve surgery: aortic valve plasty, pulmonary homograft changes for
homograft and ascending aortic reconstruction by graft were carried out
successfully. In Hungary this was the first case of this type of surgery.
Management of special problems (follow-up, correct diagnostics
(echocardiography, MR, CT), indication and necessity of reoperation, optimal
age) in adult patients with complex congenital heart defects produces excellent
early and late surgical results. Orv. Hetil., 2017, 158(14),
546–549
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