Salivary Gland Neoplasms in Indian Paediatric Population Visiting a Dental Institution

INTRODUCTION: With a probability of 50% malignancy, salivary gland tumors are not too commonly noticed in children and adolescents. Most of these have idiopathic etiology but a few pre-disposing factors have been reported in literature. We hereby report eighteen cases of paediatric salivary gland tumors in a study conducted from September 2013 to August 2018 at department of Oral and maxillofacial surgery at Tatyasaheb Kore Dental college and Research Centre, Kohlapur, Maharashtra, India..AIM & OBJECTIVES: This study aimed to inspect the distribution, clinical and histopathological features of salivary gland tumours in children and adolescents.MATERIAL AND METHODS: A total of 18 cases of salivary gland tumors encountered in paediatric age group were studied and explored for age, gender, site proneness and for histopathological nature.RESULTS: Female gender had a predominance over males. Parotid tumors were more common (77.78%) as compared to tumors of submandibular glands. Six cases were diagnosed with benign tumors (pleomorphic adenoma) and rest had malignant tumors (mucoepidermoid in nature). Majority of the cases did not report undergoing any prior treatment.CONCLUSION Present study revealed that salivary gland tumors in paediatric age group are quite rare with female gender being more prone. With majority of cases being mucoepidermoid in nature, parotid gland is most commonly affected

Salivary Gland Neoplasms in Indian Paediatric Population Visiting a Dental Institution

INTRODUCTION: With a probability of 50% malignancy, salivary gland tumors are not too commonly noticed in children and adolescents. Most of these have idiopathic etiology but a few pre-disposing factors have been reported in literature. We hereby report eighteen cases of paediatric salivary gland tumors in a study conducted from September 2013 to August 2018 at department of Oral and maxillofacial surgery at Tatyasaheb Kore Dental college and Research Centre, Kohlapur, Maharashtra, India..AIM & OBJECTIVES: This study aimed to inspect the distribution, clinical and histopathological features of salivary gland tumours in children and adolescents.MATERIAL AND METHODS: A total of 18 cases of salivary gland tumors encountered in paediatric age group were studied and explored for age, gender, site proneness and for histopathological nature.RESULTS: Female gender had a predominance over males. Parotid tumors were more common (77.78%) as compared to tumors of submandibular glands. Six cases were diagnosed with benign tumors (pleomorphic adenoma) and rest had malignant tumors (mucoepidermoid in nature). Majority of the cases did not report undergoing any prior treatment.CONCLUSION Present study revealed that salivary gland tumors in paediatric age group are quite rare with female gender being more prone. With majority of cases being mucoepidermoid in nature, parotid gland is most commonly affected

Monomorphic adenoma: A rare benign neoplasm of the minor salivary gland: Case report and review of literature

Monomorphic adenoma is a rare benign salivary gland epithelial tumor representing <3% of all tumors in general population, and more than 80% of them arise in the major salivary glands, mostly the parotid gland and rarely in upper lip, buccal mucosa - as observed in the present case. Monomorphic adenomas are defined as epithelial benign tumors of the salivary glands, which are not pleomorphic adenomas. Due to prognostic implications, differential diagnosis (adenocarcinoma, adenoid cystic carcinoma, basaloid squamous cell carcinoma, mucocele, sebaceous cyst, lipoma, nasolabial cyst, etc.,) is mandatory. The present case report describes a rare case of monomorphic adenoma involving minor salivary glands with added review the literature; discuss the diagnosis and management of this rare entity and special emphasis on the need for periodic follow-up, due to the important relapse potential and aggressivity of these lesions

Development and Characterization of Genic SSR Markers from Indian Mulberry Transcriptome and Their Transferability to Related Species of <i>Moraceae</i>

<div><p>Improving mulberry leaf production with enhanced leaf quality holds the key to sustain the ever increasing demand for silk. Adoption of modern genomic approaches for crop improvement is severely constrained by the lack of sufficient molecular markers in mulberry. Here, we report development and validation of 206 EST derived SSR markers using transcriptome data generated from leaf tissue of a drought tolerant mulberry genotype, Dudia white. Analysis of transcriptome data containing 10169 EST sequences, revealed 1469 sequences with microsatellite repeat motifs. We designed a total of 264 primers to the most appropriate repeat regions, of which 206 were locus specific. These markers were validated with 25 diverse mulberry accessions and their transferability to closely related species belonging to family <i>Moraceae</i> was examined. Of these markers, 189 revealed polymorphism with up to 8 allelic forms across mulberry species, genotypes and varieties with a mean of 3.5 alleles per locus. The markers also revealed higher polymorphic information content of 0.824 among the accessions. These markers effectively segregated the species and genotypes and hence, can be used for both diversity analysis and in breeding applications. Around 40% of these markers were transferable to other closely related species. Along with the other genic and genomic markers, we report a set of over 750 co-dominant markers. Using these markers we constructed the first genetic linkage map of mulberry exclusively with co-dominant markers.</p></div

Genetic diversity and polymorphic information revealed by markers developed for mulberry and other closely related species.

<p>Genetic diversity and polymorphic information revealed by markers developed for mulberry and other closely related species.</p

Validation of genic SSR markers in diverse mulberry accessions.

<p>Validation of genic SSR markers in diverse mulberry accessions.</p

Transferability and distribution pattern of mulberry EST-SSR markers in closely related species belonging to <i>Moraceae</i>.

<p>Transferability and distribution pattern of mulberry EST-SSR markers in closely related species belonging to <i>Moraceae</i>.</p

Diversity of the repeat motifs among the microsatellite harboring EST sequences.

<p>Diversity of the repeat motifs among the microsatellite harboring EST sequences.</p

Functional relevance of mulberry EST sequences annotated using NCBI database.

<p>Functional relevance of mulberry EST sequences annotated using NCBI database.</p