220 research outputs found
Three degrees of influence in virtual workshops: towards an understanding of co-creative facilitation practice in technologically mediated settings
Virtual workshops look here to stay, however much of the recent discourse fo-cuses on methods, tools, techniques and routines in abstraction from practice and practitioner. Collaborations in virtual space are necessarily changed and shaped by their technologically mediated nature. Therefore, it is imperative to enter into reflective dialogue to effectively develop future participatory and co-creative design practice in virtual settings. Several significant phenomena, oc-curring within virtual workshops, have been identified through focused co-reflection by expert design facilitators. Duality is used as a rhetorical device to explore these phenomena as complex elements that are expressions of dynamic and intertwined influences within the virtual setting. These elements are simul-taneously experienced as both enablers and barriers in virtual workshops, and are negotiated through practice. This paper positions these elements as objects for critical reflection within a propositional model of three expanding degrees of influence; stage, setting, and environment
Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires
The production of tt⟠, W+bb⟠and W+cc⟠is studied in the forward region of protonâproton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fbâ1 . The W bosons are reconstructed in the decays WââÎœ , where â denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of , and is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 0.02 \mbox{fb}^{-1}. The bosons are reconstructed in the decays , where denotes muon or electron, while the and quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions
LHCb upgrade software and computing : technical design report
This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis
Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era
The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2Ă1034
cmâ2sâ1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b â sl+lâand b â dl+lâ transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 â ÎŒ+ÎŒâ)/B(Bs â ÎŒ+ÎŒâ). Probing charm CP violation at the 10â5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier
Measurement of the J/Ï pair production cross-section in pp collisions at TeV
The production cross-section of J/Ï pairs is measured using a data sample of pp collisions collected by the LHCb experiment at a centre-of-mass energy of TeV, corresponding to an integrated luminosity of 279 ±11 pb. The measurement is performed for J/Ï mesons with a transverse momentum of less than 10 GeV/c in the rapidity range 2.0 < y < 4.5. The production cross-section is measured to be 15.2 ± 1.0 ± 0.9 nb. The first uncertainty is statistical, and the second is systematic. The differential cross-sections as functions of several kinematic variables of the J/Ï pair are measured and compared to theoretical predictions.The production cross-section of pairs is measured using a data sample of collisions collected by the LHCb experiment at a centre-of-mass energy of , corresponding to an integrated luminosity of . The measurement is performed for mesons with a transverse momentum of less than in the rapidity range . The production cross-section is measured to be . The first uncertainty is statistical, and the second is systematic. The differential cross-sections as functions of several kinematic variables of the pair are measured and compared to theoretical predictions
Measurement of the B0sâÎŒ+ÎŒâ Branching Fraction and Effective Lifetime and Search for B0âÎŒ+ÎŒâ Decays
A search for the rare decays Bs0âÎŒ+ÎŒ- and B0âÎŒ+ÎŒ- is performed at the LHCb experiment using data collected in pp collisions corresponding to a total integrated luminosity of 4.4ââfb-1. An excess of Bs0âÎŒ+ÎŒ- decays is observed with a significance of 7.8 standard deviations, representing the first observation of this decay in a single experiment. The branching fraction is measured to be B(Bs0âÎŒ+ÎŒ-)=(3.0±0.6-0.2+0.3)Ă10-9, where the first uncertainty is statistical and the second systematic. The first measurement of the Bs0âÎŒ+ÎŒ- effective lifetime, Ï(Bs0âÎŒ+ÎŒ-)=2.04±0.44±0.05ââps, is reported. No significant excess of B0âÎŒ+ÎŒ- decays is found, and a 95% confidence level upper limit, B(B0âÎŒ+ÎŒ-)<3.4Ă10-10, is determined. All results are in agreement with the standard model expectations.A search for the rare decays and is performed at the LHCb experiment using data collected in collisions corresponding to a total integrated luminosity of 4.4 fb. An excess of decays is observed with a significance of 7.8 standard deviations, representing the first observation of this decay in a single experiment. The branching fraction is measured to be , where the first uncertainty is statistical and the second systematic. The first measurement of the effective lifetime, ps, is reported. No significant excess of decays is found and a 95 % confidence level upper limit, , is determined. All results are in agreement with the Standard Model expectations
Measurements of prompt charm production cross-sections in pp collisions at TeV
Production cross-sections of prompt charm mesons are measured using data from collisions at the LHC at a centre-of-mass energy of TeV. The data sample corresponds to an integrated luminosity of pb collected by the LHCb experiment. The production cross-sections of , , , and mesons are measured in bins of charm meson transverse momentum, , and rapidity, . They cover the rapidity range and transverse momentum ranges for and and for and mesons. The inclusive cross-sections for the four mesons, including charge-conjugate states, within the range of are determined to be \begin{equation*} \sigma(pp\rightarrow D^0 X) = 1190 \pm 3 \pm 64\,\mu\text{b} \end{equation*} \begin{equation*} \sigma(pp\rightarrow D^+ X) = 456 \pm 3 \pm 34\,\mu\text{b} \end{equation*} \begin{equation*} \sigma(pp\rightarrow D_s^+ X) = 195 \pm 4 \pm 19\,\mu\text{b} \end{equation*} \begin{equation*} \sigma(pp\rightarrow D^{*+} X)= 467 \pm 6 \pm 40\,\mu\text{b} \end{equation*} where the uncertainties are statistical and systematic, respectively.Production cross-sections of prompt charm mesons are measured using data from pp collisions at the LHC at a centre-of-mass energy of 5 TeV. The data sample corresponds to an integrated luminosity of 8.60 ± 0.33 pb collected by the LHCb experiment. The production cross-sections of D, D, D , and D mesons are measured in bins of charm meson transverse momentum, p, and rapidity, y. They cover the rapidity range 2.0 < y < 4.5 and transverse momentum ranges 0 < p < 10 GeV/c for D and D and 1 < p < 10 GeV/c for D and D mesons. The inclusive cross-sections for the four mesons, including charge-conjugate states, within the range of 1 < p < 8 GeV/c are determined to be where the uncertainties are statistical and systematic, respectively.Production cross-sections of prompt charm mesons are measured using data from collisions at the LHC at a centre-of-mass energy of TeV. The data sample corresponds to an integrated luminosity of pb collected by the LHCb experiment. The production cross-sections of , , , and mesons are measured in bins of charm meson transverse momentum, , and rapidity, . They cover the rapidity range and transverse momentum ranges for and and for and mesons. The inclusive cross-sections for the four mesons, including charge-conjugate states, within the range of are determined to be \sigma(pp\rightarrow D^0 X) = 1004 \pm 3 \pm 54\,\mu\text{b} \sigma(pp\rightarrow D^+ X) = 402 \pm 2 \pm 30\,\mu\text{b} \sigma(pp\rightarrow D_s^+ X) = 170 \pm 4 \pm 16\,\mu\text{b} \sigma(pp\rightarrow D^{*+} X)= 421 \pm 5 \pm 36\,\mu\text{b} where the uncertainties are statistical and systematic, respectively
Ătude rĂ©trospective (2010-2017) de lâallo-immunisation chez 319 patients auto-immunisĂ©s. Apport et efficacitĂ© de lâallo-adsorption et des techniques complĂ©mentaires en immuno-hĂ©matologie
LâanĂ©mie hĂ©molytique auto-immune entraine une destruction accĂ©lĂ©rĂ©e des globules rouges par un mĂ©canisme immunologique. Chez les patients dont lâhĂ©molyse est sĂ©vĂšre, des transfusions sanguines permettent de compenser lâanĂ©mie. Chez ces patients, une Ă©tude rĂ©trospective a Ă©tĂ© rĂ©alisĂ©e sur une cohorte de 319 patients pris en charge par lâEFS site Mondor (CrĂ©teil) pour dĂ©terminer leur frĂ©quence dâallo-immunisation. Le faible taux dâallo-immunisation observĂ© (12%) par rapport aux donnĂ©es de la littĂ©rature (10-40%) suggĂšre de gĂ©nĂ©raliser lâutilisation de CGR phĂ©notypĂ©s RH-KEL1 pour les patients auto-immunisĂ©s. Les patients prĂ©alablement allo-immunisĂ©s ont plus de risques de sâimmuniser de nouveau (21%) et devraient ĂȘtre transfusĂ©s dans leur phĂ©notype Ă©tendu afin de limiter les impasses thĂ©rapeutiques. Le terrain auto-immun ne semble pas ĂȘtre un facteur de risque de primo allo-immunisation anti-Ă©rythrocytaire. La prise en charge dâĂ©chantillons de patients auto-immunisĂ©s est souvent un challenge technique pour le laboratoire dâimmuno-hĂ©matologie. Une Ă©tude prospective permettant de comparer la rapiditĂ© et lâefficacitĂ© des techniques employĂ©es pour sĂ©curiser la transfusion sanguine a Ă©tĂ© rĂ©alisĂ©e sur une cohorte de 11 patients auto-immunisĂ©s. Les allo-adsorptions en prĂ©sence de LISS et de PEG sont les plus efficientes pour dĂ©tecter un allo-anticorps masquĂ© par un auto-anticorps. Deux cycles dâallo-adsorption permettent dâĂ©liminer la majoritĂ© des auto-anticorps. Dans les situations dâurgence, lâassociation de dilutions au 1/2 et au 1/5 est une bonne alternative aux allo-adsorptions pour sĂ©curiser la prise en charge transfusionnelle des patients auto-immunisĂ©s
Dominant immune response to HLAâB57/B58 molecules after platelet transfusion
International audienceBackground: Patients with hematologic malignancies require prophylactic or curative platelet transfusions to prevent or treat bleeding. Treatments such as chemotherapy, radiotherapy, and hematopoietic stem cell transplantation cause persistent thrombocytopenia, necessitating platelet transfusions. However, class I HLA antibodies can cause a serious complication: immune-mediated platelet refractoriness. The mechanisms of alloimmunization are incompletely understood. We explored the immunogenicity of HLA molecules and the phenotype of the HLA-specific CD4+ T cells involved in alloimmunization.Study design and methods: We investigated the role of HLA molecules in platelet transfusion immunogenicity in a retrospective cohort study on men with specific anti-HLA who had undergone transfusion. We investigated the presence and phenotypic profile of HLA-specific CD4+ T cells in alloimmunized patients included in long-term platelet transfusion programs for hematologic malignancies.Results: More than 50% of the transfused subjects displayed an antibody response against HLA-B57 or -B58. HLA-B57-specific CD4+ T-cell responses were observed in patients alloimmunized against HLA-B57. Following specific stimulation, the patients presented HLA-specific CD4+ T cells producing tumor necrosis factor-α, interleukin (IL)-13, IL-17A, IL-2, IL-10, and IL-21.Conclusion: These results shed light on posttransfusion class I anti-HLA alloimmunization mechanisms and constitute a first step toward developing new strategies for reducing refractoriness
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