Political Polarization During the COVID-19 Pandemic

Affective polarization has increased substantially in the United States and countries of Europe over the last decades and the ramifications of the COVID-19 pandemic have the potential to drastically reinforce such polarization. I investigate the degree and dynamic of affective polarization during the COVID-19 pandemic through a two-wave panel survey with a vignette experiment in Germany fielded in April/May and July/August 2020. I 1) compare the findings to a previous study from 2017, and 2) assess how economic distress due to the crisis changes perceptions of other partisans. Results show that the public today experiences slightly stronger polarization between AfD voters and supporters of other parties. Yet, higher economic distress decreases the negative sentiment of voters of other parties towards AfD supporters. I argue that experiencing economic distress increases the awareness of political debate and the responsiveness to government decisions. Thus, in times of broad cross-party consensus, this can translate into public opinion so that it makes people less hostile towards other partisans

Income changes do not influence political involvement in panel data from six countries

The income gradient in political participation is a widely accepted stylized fact. Based on nine panel datasets from six countries, this research note asks whether income changes trigger short-term effects on political involvement. Irrespective of indicator, specification, and method (hybrid random effects models, fixed effects models with lags and leads, and error correction models), there are few significant short-term effects of income changes. In conjunction with earlier research, this finding suggests that the income gradient in political participation is likely to reflect stable differences between rich and poor voters emerging early in the life course

Immunohistochemical characterization of the 'intimal proliferation' phenomenon in Sneddon's syndrome and essential thrombocythaemia

Cellular changes were immunocytochemically characterized in skin vessels of five patients with idiopathic generalized racemose livedo (Sneddon's syndrome), and one patient with localized racemose livedo associated with essential thrombocythaemia. Antibodies against alpha-smooth muscle-actin, tropomyosin, desmin, vimentin, factor VIII-related antigen, human endothelial cells (CD31), human macrophages (CD68), and HLA-DR positive cells (CR3/43) were used. Conventional light microscopy showed, in all cases, intimal thickening of ascending arteries and arterioles as a result of an accumulation of cells and extracellular hyalinized material. None of the specimens showed infiltration with polymorphonuclear leucocytes or macrophages. The cells in the region of the intimal hyperplasia showed intense positive immunostaining for alpha-smooth muscle actin and tropomyosin. Staining for the intermediate filament desmin was localized to the resident smooth muscle cells of the media, whereas staining for vimentin was found in all types of cells in both the intima and media. Positive immunostaining for factor VIII-related antigen and CD31 was strictly confined to the endothelial cells lining the narrowed lumina of the vessels. No positive staining with either antibody was observed in totally occluded vessels. Cells in the subintimal space did not show reactivity for CD68 in any of the specimens, but two cases showed solitary cells with positive staining for HLA-DR in this region. There were no differences in staining pattern between Sneddon's syndrome and essential thrombocythaemia with any of the antibodies. Our results support the assumption that the 'intimal proliferation' in both diseases is caused by colonization of the subendothelial space with contractile cells of possible smooth muscle origin.(ABSTRACT TRUNCATED AT 250 WORDS

Choice- and decision behaviour of higher grade pupils - new empirical results

Es werden Ergebnisse aus einer empirischen Untersuchung vorgestellt. Diese Ergebnisse sind mit Hilfe des systematisch-qualitativen Verfahrens der Gruppendiskussionsmethode erzielt worden und werden im Zusammenhang mit der zu diesem Thema uneinheitlichen Literatur diskutiert. Neben den Kriterien für die Fächer- und Kurswahl wird dabei auf einige weitere nicht intendierte Folgen der Gymnasialreform eingegangen. (DIPF/Orig.)Results of an empirical study are presented. These results have been achieved by means of the systematical-qualitative procedure of group-discussion method and are discussed in connection with literature which is controversial concerning this topic. Criteria for the choice of subjects and courses are investigated as well as some other not intended consequences of higher grade reform

How populist attitudes scales fail to capture support for populists in power

Populist attitudes are generally measured in surveys through three necessary and non-compensatory elements of populism, namely anti-elitism, people-centrism, and Manicheanism. Using Comparative Study of Electoral Systems Module 5 (2016-2020) data for 30 countries, we evaluate whether this approach explains voting for populist parties across countries in Asia, Europe and the Americas. We show that the existing scales of populist attitudes effectively explain voting for populists in countries where populist leaders and parties are in opposition but fail to explain voting for populist parties in countries where they are in power. We argue that current approaches assume "the elite" to mean "politicians", thus failing to capture attitudes towards "non-political elites" often targeted by populists in office - in particular, journalists, academics/experts, bureaucrats, and corporate business leaders. The results reveal limits to the usefulness of existing survey batteries in cross-national studies of populism and emphasize the need to develop approaches that are more generalizable across political and national contexts

Die regionalökonomische Bedeutung der Universitäten in Baden-Württemberg 2022

Die Ausgaben der neun Landesuniversitäten, die Ausgaben der Studierenden und Beschäftigten für die Lebenshaltung, die Mehrausgaben der Absolventinnen und Absolventen infolge der akademischen Bildungsprämie sowie diejenigen der von den Universitäten stimulierten Ausgründungen erhöhen die Nachfrage nach Gütern und Dienstleistungen, die Wertschöpfung und die Zahl der Arbeitsplätze innerhalb des Bundeslandes. Sie stimulieren außerdem regionalökonomische Multiplikatoreffekte, indem die universitätsbedingten Ausgaben auch die indirekte und induzierte Nachfrage und Wertschöpfung bei vorgelagerten Produzenten und Zulieferern erhöhen. Der regionalwirtschaftliche Gesamteffekt setzt sich aus drei Bestandteilen zusammen. Den neun Universitäten des Landes Baden-Württemberg standen 2022 insgesamt 2.888 Mio. Euro an Landesmitteln zur Verfügung. Durch die Einwerbung von Drittmitteln, die Attraktion von Studierenden, die Qualifikation von Absolventinnen und Absolventen sowie die Unterstützung von Unternehmensgründungen generierten sie eine Wertschöpfungswirkung von 7.667 Mio. Euro im Bundesland. Je Euro, den die Universitäten an Landesmitteln netto verausgabten, errechnet sich eine Wertschöpfungswirkung von 4,98 Euro

S1 guideline: Differential diagnosis of acute and chronic redness of the lower legs

Acute or chronic redness of the lower leg is a frequent reason for visits to clinics and practices. The differential diagnosis is often challenging. The aim of this guideline is to define criteria and procedures for the differential diagnosis of acute or chronic, unilateral or bilateral redness of the lower leg. Finding the correct diagnosis is essential for selecting an appropriate treatment and can help to reduce the inappropriate use of antibiotics. The guideline committee identified the most relevant differential diagnoses: 1. erysipelas, 2. stasis dermatitis, 3. hyperergic ictus reaction, 4. superficial and deep vein thrombosis, 5. gout, 6. chronic allergic contact dermatitis, and 7. acute toxic or allergic contact dermatitis. Algorithms/diagnostic pathways, each of which can be broken down into anamnesis, clinical examination, and diagnostics, have been developed for these seven diagnoses. In addition, the guideline group identified over 40 other relevant diagnoses and summarized their characteristics in a table to facilitate further differential diagnoses

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10−7) and PKP4 (P=8.67 × 10−7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10−3]), SCZ (rg=0.34 [P=4.37 × 10−5]) and MDD (rg=0.57 [P=1.04 × 10−3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies

Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of Bipolar Disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was: (i) to detect genes and gene-sets involved in BOR; and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, Major Depression (MDD) and Schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests,and gene-set-analyses were performed in 998 BOR patients and 1,545 controls. LD score regression was used to detect genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Genebased analysis yielded two significant genes: DPYD (p=4.42x10-7) and PKP4 (p=8.67x10-7); and gene-set-analysis yielded a significant finding for exocytosis (GO:0006887, pFDR=0.019). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [p=2.99x10-3]), SCZ (rg=0.34 [p=4.37x10-5]), and MDD (rg=0.57 [p=1.04x10-3]). Our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies

Deletion of chromosomal region 8p21 confers resistance to Bortezomib and is associated with upregulated Decoy trail receptor expression in patients with multiple myeloma

Loss of the chromosomal region 8p21 negatively effects survival in patients with multiple myeloma (MM) that undergo autologous stem cell transplantation (ASCT). In this study, we aimed to identify the immunological and molecular consequences of del(8)(p21) with regards to treatment response and bortezomib resistance. In patients receiving bortezomib as a single first line agent without any high-dose therapy, we have observed that patients with del(8)(p21) responded poorly to bortezomib with 50% showing no response while patients without the deletion had a response rate of 90%. In vitro analysis revealed a higher resistance to bortezomib possibly due to an altered gene expression profile caused by del(8)(p21) including genes such as TRAIL-R4, CCDC25, RHOBTB2, PTK2B, SCARA3, MYC, BCL2 and TP53. Furthermore, while bortezomib sensitized MM cells without del(8)(p21) to TRAIL/APO2L mediated apoptosis, in cells with del(8)(p21) bortezomib failed to upregulate the pro-apoptotic death receptors TRAIL-R1 and TRAIL-R2 which are located on the 8p21 region. Also expressing higher levels of the decoy death receptor TRAIL-R4, these cells were largely resistant to TRAIL/APO2L mediated apoptosis. Corroborating the clinical outcome of the patients, our data provides a potential explanation regarding the poor response of MM patients with del(8)(p21) to bortezomib treatment. Furthermore, our clinical analysis suggests that including immunomodulatory agents such as Lenalidomide in the treatment regimen may help to overcome this negative effect, providing an alternative consideration in treatment planning of MM patients with del(8)(p21)