16,310 research outputs found
Nitrogen doping of carbon nanoelectrodes for enhanced control of DNA translocation dynamics
Controlling the dynamics of DNA translocation is a central issue in the
emerging nanopore-based DNA sequencing. To address the potential of heteroatom
doping of carbon nanostructures to achieve this goal, herein we carry out
atomistic molecular dynamics simulations for single-stranded DNAs translocating
between two pristine or doped carbon nanotube (CNT) electrodes. Specifically,
we consider the substitutional nitrogen doping of capped CNT (capCNT)
electrodes and perform two types of molecular dynamics simulations for the
entrapped and translocating single-stranded DNAs. We find that the
substitutional nitrogen doping of capCNTs stabilizes the edge-on nucleobase
configurations rather than the original face-on ones and slows down the DNA
translocation speed by establishing hydrogen bonds between the N dopant atoms
and nucleobases. Due to the enhanced interactions between DNAs and N-doped
capCNTs, the duration time of nucleobases within the nanogap was extended by up
to ~ 290 % and the fluctuation of the nucleobases was reduced by up to ~ 70 %.
Given the possibility to be combined with extrinsic light or gate voltage
modulation methods, the current work demonstrates that the substitutional
nitrogen doping is a promising direction for the control of DNA translocation
dynamics through a nanopore or nanogap based of carbon nanomaterials.Comment: 11 pages, 4 figure
Transcriptome sequencing and analysis of the zoonotic parasite Spirometra erinacei spargana (plerocercoids)
Synchronous double primary malignant tumor of the gallbladder and liver: a case report
We report a case of synchronous double primary tumor of gallbladder and liver. A 63-year-old male was admitted to the hospital complaining of abdominal discomfort. Enhanced computed tomography of the abdomen showed acute cholecystitis with tiny gallbladder stones and a 2.2 cm size enhanced nodule in the left lobe of the liver. Under the impression of acute cholecystitis with gall bladder stones and hepatocellular carcinoma of the left Liver, the patient underwent a laparotomy. At laparotomy, a mass was palpated on the surface of the neck portion of the gall bladder. Intraoperative frozen diagnosis revealed adenocarcinoma of the gall bladder. The patient was diagnosed as having gall bladder cancer and hepatocellular carcinoma, so extended cholecystectomy with dissection of regional lymph nodes and left hemihepatectomy were performed. Histological examination revealed moderated differentiated adenocarcinoma of gallbladder and hepatocellular carcinoma of liver. To our knowledge, the simultaneous occurrence of primary malignant tumor of the gallbladder and liver has never been published before. The patient is doing well with no evidence of recurrence 17 months after surgery
Batalin-Tyutin Quantization of the Chiral Schwinger Model
We quantize the chiral Schwinger Model by using the Batalin-Tyutin formalism.
We show that one can systematically construct the first class constraints and
the desired involutive Hamiltonian, which naturally generates all secondary
constraints. For , this Hamiltonian gives the gauge invariant Lagrangian
including the well-known Wess-Zumino terms, while for the corresponding
Lagrangian has the additional new type of the Wess-Zumino terms, which are
irrelevant to the gauge symmetry.Comment: 15 pages, latex, no figures, to be published in Z. Phys. C (1995
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A Reading and Writing Placement Test: Design, Evaluation, and Analysis
Placement tests, along with the growing interest in their validation, have become increasingly important in English as a Second Language programs. To this end, the present paper illustrates procedures in designing a placement test and using it to evaluate students’ language ability by means of statistical analysis. 29 participants from three proficiency levels (beginning, intermediate, and advanced) took reading and writing placement test sections. Students’ performance at each proficiency level was analyzed separately and compared across proficiency levels. In addition, analyses of responses on a survey revealed a relationship between language learning attitudes and behaviors exhibited by the participants and their performance on the placement test. Through close examination of the process of placement test design, evaluation, and analysis, this paper provides practical guidelines for reading and writing placement testing
Two-Dimensional Dirac Fermions Protected by Space-Time Inversion Symmetry in Black Phosphorus
We report the realization of novel symmetry-protected Dirac fermions in a
surface-doped two-dimensional (2D) semiconductor, black phosphorus. The widely
tunable band gap of black phosphorus by the surface Stark effect is employed to
achieve a surprisingly large band inversion up to ~0.6 eV. High-resolution
angle-resolved photoemission spectra directly reveal the pair creation of Dirac
points and their moving along the axis of the glide-mirror symmetry. Unlike
graphene, the Dirac point of black phosphorus is stable, as protected by
spacetime inversion symmetry, even in the presence of spin-orbit coupling. Our
results establish black phosphorus in the inverted regime as a simple model
system of 2D symmetry-protected (topological) Dirac semimetals, offering an
unprecedented opportunity for the discovery of 2D Weyl semimetals
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