Numerical model for steel catenary riser on seafloor support

Realistic predictions of service life of steel catenary risers (SCR) require an accurate characterization of seafloor stiffness in the region where the riser contacts the seafloor, the so-called touchdown zone. This thesis presents the initial stage of development of a simplified seafloor support model. This model simulates the seafloor-pipe interaction as a flexible pipe supported on a bed of springs. Constants for the soil springs were derived from finite element studies performed in a separate, parallel investigation. These supports are comprised of elasto-plastic springs with spring constants being a function of soil stiffness and strength, and the geometry of the trench within the touchdown zone. Deflections and bending stresses in the pipe are computed based on a finite element method and a finite difference formulation developed in this research project. The finite difference algorithm has capabilities for analyzing linear springs, non-linear springs, and springs having a tension cut-off. The latter feature simulates the effect of a pipe pulling out of contact with the soil. The model is used to perform parametric studies to assess the effects of soil stiffness, soil strength, trench geometry, amplitude of pipe displacements, pipe stiffness, and length of touchdown zone on pipe deflections and bending stresses. In conclusions, the seafloor stiffness (as characterized by the three spring parameters), the magnitude of pipe displacement, and the length of the touchdown zone all influence bending stresses in the pipe. Also, the tension cutoff effect, i.e., the pipe pulling away from the soil, can have a very large effect on bending stresses in the pipe. Neglecting this effect can lead to serious over-estimate of stress levels and excessive conservatism in design

Numerical Modeling of Seafloor Interation with Steel Catenary Riser

Realistic predictions of service life of steel catenary risers (SCR) require an accurate characterization of seafloor stiffness in the zone where the riser contacts the seafloor, the so- called touchdown area (TDA). This paper describes the key features of a seafloor-riser interaction model based on the previous experimental model tests. The seafloor is represented in terms of non-linear load-deflection (P-y) relationships, which are also able to account for soil stiffness degradation due to vertical cyclic loading. The P-y approach has some limitations, but simulations show good agreement with experimental data. Hence, stiffness degradation and rate effects during penetration and uplift motion (suction force increase) of the riser are well captured through comparison with previous experimental tests carried out at the Centre for Offshore Foundation Systems (COFS) and Norwegian Geotechnical Institute (NGI). The analytical framework considers the riser-seafloor interaction problem in terms of a pipe resting on a bed of springs, and requires the iterative solution of a fourth-order ordinary differential equation. A series of simulations is used to illustrate the capabilities of the model. Due to the non-linear soil springs with stiffness degradation it is possible to simulate the trench formation process and estimate deflections and moments along the riser length. The seabed model is used to perform parametric studies to assess the effects of stiffness, soil strength, amplitude of pipe displacements, and riser tension on pipe deflections and bending stresses. The input parameters include the material properties (usually pipe and soil), model parameters, and loading conditions such as the amplitude of imposed dis- placements, tension, and moment. Primary outputs from this model include the deflected shape of the riser pipe and bending moments along riser length. The code also provides the location of maximum trench depth and the position where the maximum bending moment occurs and any point where user is interested in

Eigen damping constant of spin waves in ferromagnetic nanostructure

Though varying in nature, all waves share traits in a way that they all follow the superposition principle while also experiencing attenuation as they propagate in space. And thus it is more than common that a comprehensive investigation of one type of wave leads to a discovery that can be extended to all kinds of waves in other fields of research. In the field of magnetism, the wave of interest corresponds to the spin wave (SW). Specifically, there has been a push to use SWs as the next information carriers similar to how electromagnetic waves are used in photonics. At present, the biggest impediment in making SW-based device to be widely adapted is the fact that the SW experiences large attenuation due to the large damping constant. Here, we developed a method to find the SW eigenmodes and show that their respective eigen damping constants can be 40% smaller than the typical material damping constant. From a bigger perspective, this finding means that the attenuation of SW and also other types of waves in general is no more constrained by the material parameters, and it can be controlled by the shape of the waves instead. © 2019, The Author(s).1

Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study

PURPOSE: The present study evaluated whether oral supplementation with a branched-chain amino acid (BCAA) improves the biochemical and amino acid profiles of liver tumor patients undergoing radiotherapy. MATERIALS AND METHODS: Patients were randomly assigned to one of 2 groups: a group given oral supplementation with BCAA granules (LIVACT granules; Samil Pharm Co., Korea, each granule containing L-isoleucine 952 mg, L-leucine 1,904 mg, and L-valine 1,144 mg) during radiotherapy, or a placebo group. Physical and biochemical examinations and measurements, including subjective symptoms, Child-Pugh class, body mass index, plasma albumin concentration, and plasma amino acid profiles were monitored. RESULTS: Fifty were enrolled between November 2005 and November 2006. We also analyzed data from 37 hepatocellular carcinoma (HCC) patients in order to evaluate a more homogenous group. The two groups of patients were comparable in terms of age, gender, Child-Pugh score, and underlying hepatitis virus type. Serum albumin, total protein, liver enzymes, and cholesterol showed a tendency to increase in the BCAA group. In this group, the percentage of cases that reverted to normal serum albumin levels between 3 and 10 weeks after administration of BCAA was significantly higher (41.18%) than in the placebo group (p=0.043). CONCLUSION: Oral supplementation with a BCAA preparation seems to help HCC patients undergoing radiotherapy by increasing the BCAA concentration.ope

Effect of Hydraulic Activity on Crystallization of Precipitated Calcium Carbonate (PCC) for Eco-Friendly Paper

Wt% of aragonite, a CaCO3 polymorph, increased with higher hydraulic activity (°C) of limestone in precipitated calcium carbonate (PCC) from the lime-soda process (Ca(OH)2-NaOH-Na2CO3). Only calcite, the most stable polymorph, was crystallized at hydraulic activity under 10 °C, whereas aragonite also started to crystallize over 10 °C. The crystallization of PCC is more dependent on the hydraulic activity of limestone than CaO content, a factor commonly used to classify limestone ores according to quality. The results could be effectively applied to the determination of polymorphs in synthetic PCC for eco-friendly paper manufacture

Fatal Neutropenic Enterocolitis during Pegylated Interferon and Ribavirin Combination Therapy for Chronic Hepatitis C Virus Infection

It is known that neutropenia caused by combination pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) infection is well tolerated and carries a negligible risk of infection. Neutropenic enterocolitis is encountered most frequently in patients with hemato-oncologic diseases who are undergoing intensive chemotherapy. However, little information exists regarding this life-threatening event in the setting of HCV therapy. We present here an unusual case of fatal neutropenic enterocolitis in a cirrhotic patient receiving combination therapy for HCV infection. This is the first report of a death from neutropenic enterocolitis associated with treatment for chronic HCV infection. The present case suggests that caution should be exercised when continuing HCV therapy in neutropenic patients with advanced fibrosis, and the decision to maintain such therapy should be balanced against the potential for serious adverse events

Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study

Background: NIRSIT, a functional near-infrared spectroscopy (fNIRS) device with 204 channels, can measure oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in non-pulsatile blood flow non-invasively using the absorption difference between HbO2 and HbR at a wavelength of 700–1,000 nm and can display the perfusion status in real time.Objective: We applied NIRSIT to patients with stroke to evaluate the usefulness of NIRSIT as an fNIRS device for the early detection of stroke.Methods: We performed a prospective pilot study in an emergency department (ED). Adult patients who had suspected symptoms and signs of stroke within 12 h of the first abnormal time and who underwent intravenous thrombolysis (IVT) or intra-arterial thrombectomy with acute middle cerebral artery (MCA) or internal carotid artery (ICA) infarction were enrolled. NIRSIT was applied to the patients before the imaging study, and the perfusion status of the brain was displayed in real time at the bedside. We compared the NIRSIT results with the mean transit time (MTT) map from perfusion computed tomography (PCT) and the time-to-peak (TTP) map from perfusion-weighted magnetic resonance imaging (PWI).Results: Six male and three female patients were enrolled, and the median age was 74 years. The most common symptom was unilateral extremity weakness (77.8%), followed by dysarthria (33.3%) and aphasia (11.1%). The median National Institutes of Health Stroke Scale (NIHSS) score was 17. All cases of MCA infarction showed different cerebral oxygen saturation values between bilateral lobes of the brain in fNIRS imaging, and these values matched the PCT and PWI results.Conclusions: The brain hemisphere with low oxygen saturation on fNIRS showed hypoperfusion on PCT or PWI. The fNIRS device could be useful in assessing the perfusion status of the brain and detecting MCA or ICA infarction in real time at the bedside