Ethical Attitudes toward Buying and Selling Counterfeits: Beneficial Lies, Belief in Fairness, and Non-monetary Values

The purpose of the study is to examine how values, explicitly (1) tolerance of beneficial lies, (2) belief in fairness, and (3) belief in non-monetary values, are related to attitudes toward buying and selling counterfeits

Radiofrequency Ablation of Thyroid Nodules: Basic Principles and Clinical Application

Radiofrequency (RF) ablation has been gaining popularity as a minimally invasive treatment for benign thyroid nodules regardless of the extent of the solid component. RF ablation of benign nodules demonstrated volume reductions of 33–58% after one month and 51–85% after six months, while solving nodule-related clinical problems. RF ablation has recently shown positive short-term results for locoregional control as well as symptom improvement in patients with recurrent thyroid cancers. This paper reviews the basic physics, indications, patient preparation, devices, procedures, clinical results, and complications of RF ablation

TAZ Suppresses NFAT5 Activity through Tyrosine Phosphorylation

Transcriptional coactivator with PDZ-binding motif (TAZ) physically interacts with a variety of transcription factors and modulates their activities involved in cell proliferation and mesenchymal stem cell differentiation. TAZ is highly expressed in the kidney, and a deficiency of this protein results in multiple renal cysts and urinary concentration defects; however, the molecular functions of TAZ in renal cells remain largely unknown. In this study, we examined the effects of osmotic stress on TAZ expression and activity in renal cells. We found that hyperosmotic stress selectively increased protein phosphorylation at tyrosine 316 of TAZ and that this was enhanced by c-Abl activation in response to hyperosmotic stress. Interestingly, phosphorylated TAZ physically interacted with nuclear factor of activated T cells 5 (NFAT5), a major osmoregulatory transcription factor, and subsequently suppressed DNA binding and transcriptional activity of NFAT5. Furthermore, TAZ deficiency elicited an increase in NFAT5 activity in vitro and in vivo, which then reverted to basal levels following restoration of wild-type TAZ but not mutant TAZ (Y316F). Collectively, the data suggest that TAZ modulates cellular responses to hyperosmotic stress through fine-tuning of NFAT5 activity via tyrosine phosphorylation.open3

Escuelas promotoras de la salud: un programa multicompente para prevenir los riesgos conductuales en adolescentes (2014-2017)

DOI: 10.26439/persona2020.n023(1).4834 This article is based on the analysis of the systematization of the Health Promoting School project implemented in Lima, Peru, from 2014 to 2017 by an agreement between the International cooperation agency of South Korea and the Ministry of health in Peru. A description of the phases developed, the strategies used, and the alliances built for their implementation will be presented. For that purpose, a review of secondary sources and interviews to key players as primary sources were made. The project considered the prevention and health promotion paradigms as complementary ones.DOI: 10.26439/persona2020.n023(1).4834 Este artículo se basa en el análisis de la sistematización del Proyecto de las Escuelas Promotoras de la Salud, implementado en Lima, Perú, del 2014 al 2017, a través de un acuerdo entre la Agencia de Cooperación Internacional de Corea del Sur, y el ministerio de Salud de Perú. Se describe el desarrollo de las fases del proyecto, las estrategias que se usaron, así como las alianzas que se construyeron para la implementación del proyecto. Para el análisis se revisaron fuentes secundarias y se entrevistaron a los agentes clave, como fuentes primarias. Consideramos que los paradigmas de prevención y promoción de la salud deben ser considerados como complementarios

Eosinophilic gastroenteritis in an 18-year-old male with prolonged nephrotic syndrome

Eosinophilic gastroenteritis is a rare disease characterized by prominent eosinophilic tissue infiltration of the gastrointestinal tract. Here, we report a case of eosinophilic gastroenteritis in an 18-year-old patient with prolonged nephrotic syndrome who presented with abdominal pain and peripheral hypereosinophilia. During the previous 2 years, he had visited local Emergency Department several times because of epigastric pain and nausea. He had been treated with steroid-dependent nephrotic syndrome since 3 years of age. Tests ruled out allergic and parasitic disease etiologies. Gastroduodenoscopy with biopsy revealed marked eosinophilic infiltration in the duodenum. Renal biopsy findings indicated minimal change disease spectrum without eosinophilic infiltration. The oral deflazacort dosage was increased, and the patient was discharged after abdominal pain resolved. To our knowledge, this is the first report of eosinophilic gastroenteritis in a patient with minimal change disease

Functional magnetic resonance imaging multivoxel pattern analysis reveals neuronal substrates for collaboration and competition with myopic and predictive strategic reasoning

Competition and collaboration are strategies that can be used to optimize the outcomes of social interactions. Research into the neuronal substrates underlying these aspects of social behavior has been limited due to the difficulty in distinguishing complex activation via univariate analysis. Therefore, we employed multivoxel pattern analysis of functional magnetic resonance imaging to reveal the neuronal activations underlying competitive and collaborative processes when the collaborator/opponent used myopic/predictive reasoning. Twenty- four healthy subjects participated in 2- Ã - 2 matrix- based sequential- move games. Searchlight- based multivoxel patterns were used as input for a support vector machine using nested cross- validation to distinguish game conditions, and identified voxels were validated via the regression of the behavioral data with bootstrapping. The left anterior insula (accuracy = 78.5%) was associated with competition, and middle frontal gyrus (75.1%) was associated with predictive reasoning. The inferior/superior parietal lobules (84.8%) and middle frontal gyrus (84.7%) were associated with competition, particularly in trials with a predictive opponent. The visual/motor areas were related to response time as a proxy for visual attention and task difficulty. Our results suggest that multivoxel patterns better represent the neuronal substrates underlying the social cognition of collaboration and competition intermixed with myopic and predictive reasoning than do univariate features.We employed multivoxel pattern analysis of functional magnetic resonance imaging to reveal the neuronal activations underlying competitive and collaborative processes when the collaborator/opponent used myopic/predictive reasoning in 2- Ã - 2 matrix- based sequential- move games. Searchlight- based multivoxel patterns and support vector machine were used in a nested cross- validation to distinguish game conditions, and identified voxels in the left anterior insula, middle frontal gyrus, and inferior/superior parietal lobules were validated via the regression of the behavioral data with bootstrapping by excluding potential visual attention component. Our results suggest that multivoxel patterns better represent the neuronal substrates underlying the social cognition of collaboration and competition intermixed with myopic and predictive reasoning than do univariate features.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162700/3/hbm25127-sup-0001-Supinfo.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162700/2/hbm25127_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162700/1/hbm25127.pd