A supramolecular radical cation: folding-enhanced electrostatic effect for promoting radical-mediated oxidation.

We report a supramolecular strategy to promote radical-mediated Fenton oxidation by the rational design of a folded host-guest complex based on cucurbit[8]uril (CB[8]). In the supramolecular complex between CB[8] and a derivative of 1,4-diketopyrrolo[3,4-c]pyrrole (DPP), the carbonyl groups of CB[8] and the DPP moiety are brought together through the formation of a folded conformation. In this way, the electrostatic effect of the carbonyl groups of CB[8] is fully applied to highly improve the reactivity of the DPP radical cation, which is the key intermediate of Fenton oxidation. As a result, the Fenton oxidation is extraordinarily accelerated by over 100 times. It is anticipated that this strategy could be applied to other radical reactions and enrich the field of supramolecular radical chemistry in radical polymerization, photocatalysis, and organic radical battery and holds potential in supramolecular catalysis and biocatalysis

The Role of Deubiquitinases in DNA Double-Strand Break Repair

DNA double-strand break (DSB) is a type of the most critical DNA lesions, and if not repaired promptly, it can result in cell death or a wide variety of genetic alterations including genome instability, large- or small-scale deletions, chromosome loss, loss of heterozygosity, and translocations. DSBs are repaired by double-strand break repair (DSBR), including nonhomologous end-joining (NHEJ) and homologous recombination (HR) pathway, and defects in these pathways cause genome instability and promote tumorigenesis. Accumulating evidence has demonstrated that the superfamily of deubiquitinases (DUBs) can regulate the action and stability of DNA repair enzymes involving in DSBR via modifying ubiquitination levels, a reversible posttranslational modification pathway. In this review, we will discuss ubiquitination/deubiquitination modification involving in DSBR genes, the role of DUBs in DSBR and corresponding mechanisms, and the potential effects of this modification on human diseases

A fringe projection profilometry scheme based on embedded speckle patterns and robust principal component analysis

2019 SPIE. Phase unwrapping is one of the key steps for fringe projection profilometry (FPP)-based 3D shape measurements. Conventional spatial phase unwrapping schemes are sensitive to noise and discontinuities, which may suffer from low accuracies. Temporal phase unwrapping is able to improve the reliability but often requires the acquisition of additional patterns, increasing the measurement time or hardware costs. This paper introduces a novel phase unwrapping scheme that utilizes composite patterns consisting of the superposition of standard sinusoidal patterns and randomly generated speckles. The low-rankness of the deformed sinusoidal patterns is studied. This is exploited together with the sparse nature of the speckle patterns and a robust principal component analysis (RPCA) framework is then deployed to separate the deformed fringe and speckle patterns. The cleaned fringe patterns are used for generating the wrapped phase maps using the standard procedures of phase shift profilometry (PSP) or Fourier Transform profilometry (FTP). Phase unwrapping is then achieved by matching the deformed speckle patterns that encode the phase order information. In order to correct the impulsive fringe order errors, a recently proposed postprocessing step is integrated into the proposed scheme to refine the phase unwrapping results. The analysis and simulation results demonstrate that the proposed scheme can improve the accuracy of FPP-based 3D shape measurements by effectively separating the fringe and speckle patterns

8-Thia-1,6-diaza­bicyclo­[4.3.0]nonane-7,9-dione

There are two independent mol­ecules, A and B, in the asymmetric unit of the title compound, C6H8N2O2S. In the crystal, pairs of inter­molecular S⋯O contacts [3.286 (1) Å] link the B mol­ecules into inversion dimers

Bis(4′-hy­droxy­biphenyl-4-carboxyl­ato-κO 1)(1,10-phenanthroline-κ2 N,N′)zinc

In the title compound, [Zn(C13H9O3)2(C12H8N2)], the ZnII atom is located on a twofold rotation axis and has a distorted tetra­hedral coordination with two N atoms from the phenanthroline ligand arranged around the twofold axis and two O atoms from two symmetry-related 4′-hy­droxy­biphenyl-4-carboxyl­ate ligands. The mol­ecules are linked by O—H⋯O hydrogen bonds, forming a chain developing parallel to [101]