A note on the fractional Cauchy problems with nonlocal initial conditions

AbstractOf concern is the Cauchy problems for fractional integro-differential equations with nonlocal initial conditions. Using a new strategy in terms of the compactness of the semigroup generated by the operator in the linear part and approximating technique, a new existence theorem for mild solutions is established. An application to a fractional partial integro-differential equation with a nonlocal initial condition is also considered

Luteoloside Inhibits Proliferation of Human Chronic Myeloid Leukemia K562 Cells by Inducing G2/M Phase Cell Cycle Arrest and Apoptosis

Purpose: To investigate the effects of luteoloside on the proliferation of human chronic myeloid leukemia K562 cells and whether luteoloside induces cell cycle arrest and apoptosis in K562 cells.Methods: Luteoloside’s cytotoxicity was assessed using a cell counting kit. Cell cycle distribution was analysed by flow cytometry after propidium iodide (PI) staining. Cell apoptosis was assayed with apoptosis detection kit and Hoechst staining followed by observation under a fluorescence microscope. The expression of cell cycle- and apoptosis-related proteins was examined by Western blot analysis.Results: Luteoloside inhibited the proliferation of K562 cells in a dose- and time- dependent manner (IC50 = 30.7 μM) with less toxicity in a normal human cell line (IC50 = 91.8 μM). Moreover, antiproliferative effect of luteoloside was accompanied with G2/M phase arrest（p ＜ 0.05 or p＜0.01） and apoptosis（p ＜ 0.01 or p ＜ 0.001）. Further studies revealed that the expression level of cyclinB1 was down-regulated by luteoloside treatment. Furthermore, luteoloside treatment also increased proapoptotic protein Bax expression and decreased anti-apoptotic protein Bcl-2 expression.Conclusion: These results suggest that the inhibitory effect of luteoloside on K562 cell proliferation is associated with inducing G2/M phase arrest and apoptosis, and that luteoloside is worth further studying for anticancer potential.Keywords: Luteoloside, Myeloid leukemia, Proliferation, Cell cycle arrest, Apoptosis, Anticance

ClockViz: Designing Public Visualization for Coping with Collective Stress in Teamwork

The intervention solutions for coping with collective stress have been neglected in interaction design because of limited scalability of the physiological measuring methods. This paper focuses on exploring visual biofeedback design for collective stress in the context of teamwork. We design ClockViz, an augmented reality installation overlaid with static or dynamic projection to visualize three different extents of collective stress on a clock. Results of a 16-participant study show that ClockViz is useful to provide biofeedback data, change their internal status, and increase their mindfulness. Based on the results, we also discussed the potential solutions to collective stress sensing for designers to apply into their interactive design intervention

Sensor placement in the noise source identification based on acoustic radiation modes

The noise source identification technology based on acoustic radiation modes could identify the noise source under less measuring points, while the sensor placement has great influence on the result of noise source identification. Under the prescribed number of sensors, a method to configure the measuring points is proposed. By the means of successive removal, select a set of measuring points in the candidate field points, which make the orthogonality of the acoustic field distribution modes matrix achieve the maximum value. The results of numerical simulation and sound box experiment have shown that when sensors are arranged in accordance with the measuring points selected by this method, the noise source could be identified effectively, and the identification result is better than that when sensors are arranged evenly

The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model

Electroacupuncture (EA), especially high-frequency EA, has frequently been used as an alternative therapy for Parkinson disease (PD) and is reportedly effective for alleviating motor symptoms in patients and PD models. However, the molecular mechanism underlying its effectiveness is not completely understood. To implement a full-scale search for the targets of 100 Hz EA, we selected rat models treated with 6-hydroxydopamine into the unilateral MFB, which mimic end-stage PD. High-throughput microarray analysis was then used to uncover the regulated targets in the cortex and striatum after 4-week EA treatment. In the differentially regulated transcripts, the proportion of recovered expression profiles in the genes, the functional categories of targets in different profiles, and the affected pathways were analyzed. Our results suggested that the recovery of homeostasis in the transcript network and many regulated functional clusters in the cortex and striatum after EA treatment may contribute to the behavioral improvement of PD rats

A Universe of ultradiffuse galaxies: theoretical predictions from ΛCDM simulations

A particular population of galaxies have drawn much interest recently, which are as faint as typical dwarf galaxies but have the sizes as large as L* galaxies, the so called ultradiffuse galaxies (UDGs). The lack of tidal features of UDGs in dense environments suggests that their host haloes are perhaps as massive as that of the Milky Way. On the other hand, galaxy formation efficiency should be much higher in the haloes of such masses. Here, we use the model galaxy catalogue generated by populating two large simulations: the Millennium-II cosmological simulation and Phoenix simulations of nine big clusters with the semi-analytic galaxy formation model. This model reproduces remarkably well the observed properties of UDGs in the nearby clusters, including the abundance, profile, colour and morphology, etc. We search for UDG candidates using the public data and find two UDG candidates in our Local Group and 23 in our Local Volume, in excellent agreement with the model predictions. We demonstrate that UDGs are genuine dwarf galaxies, formed in the haloes of ∼1010 M⊙. It is the combination of the late formation time and high spins of the host haloes that results in the spatially extended feature of this particular population. The lack of tidal disruption features of UDGs in clusters can also be explained by their late infall-time

Guest Editorial: Social and human aspects of cyber-physical systems

open6siIn the vision of Industry 4.0, the new industrial revolution is a revolution of cyber-physical systems, of which the Internet of Things forms a key foundation that has a great impact on the way people live, and the way businesses are organised. Cyber-physical systems are often considered feedback systems that integrate computation, networking, and physical processes, and more recently with ‘human-in-the-loop’ as one of the key research topics. The advances in social computing have connected human-inthe-loop in cyber-social systems such as Facebook and Twitter, while their social-physical activities are supported by the cyberphysical systems on or near their bodies and in their interconnected environments. Cyber-physical systems become an integral part of social-cyber-physical systems (SCPS) that weave into the sociotechnical fabric of human society. These hybrid systems, exhibiting both continuous (in physical and social spaces) and discrete (in cyberspaces) dynamic behaviour, give rise to not only new opportunities but also new challenges in designing products and services where human and technical aspects are massively intertwined. This Special Issue aims to present state-of-the-art research attempts and results on the topic of SCPS.openopenHu J.; Liang R.-H.; Shih C.-S.; Catala A.; Marcenaro L.; Osawa H.Hu, J.; Liang, R. -H.; Shih, C. -S.; CATALA MALLOFRE, Andreu; Marcenaro, L.; Osawa, H