Quantized spin Hall effect in Helium three-A and other p-wave paired Fermi systems

In this paper we propose the quantized spin Hall effect (SHE) in the vortex state of a rotating p-wave paired Fermi system in an inhomogeneous magnetic field and in a weak periodic potential. It is the three dimensional extension of the spin Hall effect for a 3He-A superfluid film studied in Ref. [1]. It may also be considered as a generalization of the 3D quantized charge Hall effect of Bloch electrons in Ref. [2] to the spin transport. The A-phase of 3He or, more generally, the p-wave paired phase of a cold Fermi atomic gas, under suitable conditions should be a good candidate to observe the SHE, because the system has a conserved spin current (with no spin-orbit couplings).Comment: 6 pages, revised version

Bayesian Linear Regression with Cauchy Prior and Its Application in Sparse MIMO Radar

In this paper, a sparse signal recovery algorithm using Bayesian linear regression with Cauchy prior (BLRC) is proposed. Utilizing an approximate expectation maximization(AEM) scheme, a systematic hyper-parameter updating strategy is developed to make BLRC practical in highly dynamic scenarios. Remarkably, with a more compact latent space, BLRC not only possesses essential features of the well-known sparse Bayesian learning (SBL) and iterative reweighted l2 (IR-l2) algorithms but also outperforms them. Using sparse array (SPA) and coprime array (CPA), numerical analyses are first performed to show the superior performance of BLRC under various noise levels, array sizes, and sparsity levels. Applications of BLRC to sparse multiple-input and multiple-output (MIMO) radar array signal processing are then carried out to show that the proposed BLRC can efficiently produce high-resolution images of the targets.Comment: 22 page

The Extending of Observing Altitudes of Plasma and Ion Lines During Ionospheric Heating

Source at https://doi.org/10.1002/2017JA024809. The ultrahigh-frequency observation during an ionospheric heating experiment on 11 March 2014 at the European Incoherent Scatter Scientific Association Tromsø site illustrated a remarkable extension of observing altitudes of the enhanced plasma line and the ion line, implying that the enhanced ion acoustic wave and Langmuir wave should satisfy the Bragg condition within the extending altitude range. An analysis shows that the dependence of the wave number of the traveling ion acoustic wave on the profiles of enhanced electron temperature and ion mass, as are expected from the dispersion relation of the ion acoustic wave, leads to the extension of observing altitudes of the enhanced ion line. In addition, the altitude extension of the enhanced plasma line is dependent mainly on the profile of the electron density, although it is not independent of the profile of the electron temperature. Considering a small gradient profile of electron density, however, the enhanced electron temperature, as well as the thermal conduction along the magnetic field, may lead to the altitude extension of the enhanced plasma line

The N terminus of phosducin is involved in binding of βγ subunits of G protein

Phosducin is a soluble phosphoprotein found in retinal photoreceptor cells and in the pineal gland. It binds to the βγ subunits of guanine nucleotide-binding proteins (G proteins) (Gβγ) and may regulate G-protein function. In this study, the ability of specific regions of phosducin to bind Gβγ was characterized. A series of deletion mutants were made in bovine phosducin. They were tested in cotransfection assays for their ability to inhibit Gβγ-mediated phospholipase C β_2 isoform activation. Overexpression of the N-terminal half of phosducin showed inhibition, whereas overexpression of the C-terminal half did not. The first 63 amino acid residues were required for inhibition. A tryptophan-to-valine substitution at residue 29, which is part of a well conserved 11-amino acid sequence, severely impaired phosducin inhibitory function. Glutathione S-transferase-phosducin fusion proteins were expressed in Escherichia coli to study phosducin-Gβγ interaction in vitro. The N-terminal 63-amino acid fragment was able to bind to Gβγ. In contrast, the C-terminal half failed to bind to Gβγ. The substitution mutants showed little or no binding. Furthermore, direct measurements of interaction between Gβγ and fragments of phosducin, using surface plasmon resonance technology, confirmed the assignment of binding activity to the 63-amino acid fragment and the importance of the tryptophan residu

Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and cortex plays an important role in chronic pain, including inflammatory and neuropathic pain. While recent studies indicate that microglia in the spinal cord are involved in neuropathic pain, a systematic study has not been performed in other regions of the central nervous system (CNS). In the present study, we used heterozygous Cx3cr1GFP/+mice to characterize the morphological phenotypes of microglia following common peroneal nerve (CPN) ligation. We found that microglia showed a uniform distribution throughout the CNS, and peripheral nerve injury selectively activated microglia in the spinal cord dorsal horn and related ventral horn. In contrast, microglia was not activated in supraspinal regions of the CNS, including the anterior cingulate cortex (ACC), prefrontal cortex (PFC), primary and secondary somatosensory cortex (S1 and S2), insular cortex (IC), amygdala, hippocampus, periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Our results provide strong evidence that nerve injury primarily activates microglia in the spinal cord of adult mice, and pain-related cortical plasticity is likely mediated by neurons

Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells

<p>Abstract</p> <p>Background</p> <p>This study investigates whether protein kinase G (PKG), protein kinase A (PKA) and protein kinase C (PKC) are involved in the regulatory mechanisms of store-operated channel (SOC) in pulmonary arteries.</p> <p>Methods</p> <p>Pulmonary artery smooth muscle cells (PASMCs) were enzymatically dissociated from rat intralobar pulmonary arteries. Whole cell, cell-attached and inside-out patch-clamp electrophysiology were used to monitor SOCs in isolated PASMCs.</p> <p>Results</p> <p>Initially the Ca²⁺-ATPase inhibitor cyclopiazonic acid (CPA, 10 μM) initiated a whole cell current that was reduced by the SOC blocker SKF-96365 (10 μM). Subsequent work using both cell-attached and whole cell configurations revealed that the PKG and PKA inhibitors, KT5823 (3 μM) and H-89 (10 μM), also stimulated SOC activity; this augmentation was attenuated by the SOC blockers SKF-96365 (10 μM) and Ni²⁺(0.1 mM). Finally using the inside-out configuration, the PKC activator phorbol 12-myristate 13-acetate (PMA, 10 μM) was confirmed to modestly stimulate SOC activity although this augmentation appeared to be more substantial following the application of 10 μM inositol 1,4,5-triphosphate (Ins(1,4,5)P₃).</p> <p>Conclusions</p> <p>SOC activity in PASMCs was stimulated by the inhibition of PKG and PKA and the activation of PKC. Our findings suggest that the SOC could be a substrate of these protein kinases, which therefore would regulate the intracellular concentration of calcium and pulmonary arteriopathy via SOC.</p

Nano-optomechanical nonlinear dielectric metamaterials

By harnessing the resonant nature of localized electromagnetic modes in a nanostructured silicon membrane, an all-dielectric metamaterial can act as nonlinear medium at optical telecommunications wavelengths. We show that such metamaterials provide extremely large optomechanical nonlinearities, operating at intensities of only a few μW per unit cell and modulation frequencies as high as 152 MHz, thereby offering a path to fast, compact and energy efficient all-optical metadevices