Individual risk profiling for portable devices using a neural network to process the cognitive reactions and the emotional responses to a multivariate situational risk assessment

In this paper, we are presenting a novel method and system for neuropsychological performance testing that can establish a link between cognition and emotion. It comprises a portable device used to interact with a cloud service which stores user information under username and is logged into by the user through the portable device; the user information is directly captured through the device and is processed by artificial neural network; and this tridimensional information comprises user cognitive reactions, user emotional responses and user chronometrics. The multivariate situational risk assessment is used to evaluate the performance of the subject by capturing the 3 dimensions of each reaction to a series of 30 dichotomous questions describing various situations of daily life and challenging the user's knowledge, values, ethics, and principles. In industrial application, the timing of this assessment will depend on the user's need to obtain a service from a provider such as opening a bank account, getting a mortgage or an insurance policy, authenticating clearance at work or securing online payments

Decentralized nation, solving the web identity crisis

The web of today whether you prefer to call it web 2.0, web 3.0, web 5.0 or even the metaverse is at a critical stage of evolution and challenge, largely centered around its crisis of identity. Like teenagers who cannot assess properly their reason for being and do not seem ready to take responsibility for their actions, we are constantly blaming the very system we are trying to get away from. To truly realize the benefits from innovation and technology, this crisis has to be resolved, not just through tactical solutions but through developments that enhance the sustainability of the web and its benefits. Significant strides are being made in the evolution of digital services enabled by technology, regulation, and the sheer pace of societal change. The journey to the decentralized web is mirroring the convergence of the physical and digital worlds across all economies and is increasingly embracing the digital native world. Technology has provided the foundational platform for individuals and entities to create and manage wealth, potentially without the need for big institutions. Ironically, despite all of the advancements, we are still facing an unprecedented and increasing wealth gap. Clearly, the system is broken, not just around the edges but at the very core of the democratic underpinning of our society. In this whitepaper, we propose how artificial intelligence on blockchain can be used to generate a new class of identity through direct human computer interaction. We demonstrate how this, combined with new perspectives for sustaining community and governance embedded within the use of blockchain technology, will underpin a sustainable solution to protect identity, authorship and privacy at the same time while contributing to restore trust amongst members of a future decentralized nation and hence contribute to solving the web most significant identity crisis.Comment: 11 pages, 1 figur

Advances and limitations of drug delivery systems formulated as eye drops.

Topical instillation of eye drops remains the most common and easiest route of ocular drug administration, representing the treatment of choice for many ocular diseases. Nevertheless, low ocular bioavailability of topically applied drug molecules can considerably limit their efficacy. Over the last several decades, numerous drug delivery systems (DDS) have been developed in order to improve drug bioavailability on the ocular surfaces. This review systematically covers the most recent advances of DDS applicable by topical instillation, that have shown better performance in in vivo models compared to standard eye drop formulations. These delivery systems are based on in situ forming gels, nanoparticles and combinations of both. Most of the DDS have been developed using natural or synthetic polymers. Polymers offer many advantageous properties for designing advanced DDS including biocompatibility, gelation properties and/or mucoadhesiveness. However, despite the high number of studies published over the last decade, there are several limitations for clinical translation of DDS. This review article focuses on the recent advances for the development of ocular drug delivery systems. In addtion, the potential challenges for commercialization of new DDS are presented

Lived Experiences of Mental Health Service Frontliners Amidst the COVID-19 Pandemic

While there’s an abundant literature describing the experiences of medical frontliners amidst the pandemic, there is a dearth of studies pertaining to the experiences of mental health frontliners. This study aims to explore the lived experiences of mental health service providers who cater psychological services to COVID-19 patients and survivors. Using interpretative phenomenological analysis (IPA), this study extracted seven central meanings from the interview responses of eight mental health frontliners. The central meanings are 1) Experiencing Mental Health Concerns; 2) Challenges in Delivery of Online Mental Health Services; 3) Aggravating Concerns in the Profession; 4) Bolstering Personal and Professional Development; 5) Personal and Professional; 6) Adjustments to Pandemic-Related Frustrations; and 7) Social Support as Primary Way of Coping. The mental health concerns experienced by the participants are seemingly affected by the difficulty they experience in delivering online psychological services and their lack of resources and workforce to effectively do so. The participants’ social support and the adjustments they made in the personal and professional lives allowed them to navigate through the problems brought by the pandemic. Eventually, participants bolstered their personal and professional development which also helped them to better address the problems they encountered in their personal lives and in their line of profession

Ignames sauvages et Ignames cultivées à Madagascar

Jumelle Henri. Ignames sauvages et Ignames cultivées à Madagascar. In: Revue de botanique appliquée et d'agriculture coloniale, 2ᵉ année, bulletin n°9, 31 mai 1922. pp. 193-197

Le Quebracho.

Jumelle H. Le Quebracho. In: Revue de botanique appliquée et d'agriculture coloniale, 4ᵉ année, bulletin n°30, 29 février 1924. pp. 88-98

Delivery of molecules into corneal endothelial cells by carbon nanoparticles activated by femtosecond laser

Les cellules endothéliales cornéennes (CEC) jouent un rôle essentiel pour le maintien de la transparence de la cornée. Cependant, chez l’homme, elles sont incapables de proliférer en raison d’un arrêt de leur cycle cellulaire en phase G1, ce qui rend la couche endothéliale cornéenne particulièrement vulnérable. La délivrance de molécules thérapeutiques (gènes ou médicaments) représente une solution prometteuse pour maintenir la viabilité des CEC. Néanmoins, la difficulté majeure de cette technique repose sur le fait de traverser la membrane cellulaire, normalement imperméable aux molécules de grande taille. Plusieurs techniques de délivrance de molécules ont déjà été testées sur le tissu cornéen mais aucune d’entre elles ne donnent de résultats suffisamment probants pour être utilisée en applications cliniques. L’objectif de cette thèse est d’adapter et de développer une nouvelle technique de délivrance intracellulaire de molécules, basé sur une perforation cellulaire via un phénomène photoacoustique induite par l’activation de nanoparticules de carbone par laser femtoseconde, sur un modèle d’endothélium cornéen in vitro et ex vivoCorneal endothelial cells (CEC) are essential for corneal transparency. However, on humans, they are unable of proliferation owing to its arrest of G1 phase of the cell cycle, making corneal endothelial monolayer particularly vulnerable. The gene and drug delivery represents a promising solution to maintain CEC viability. Unfortunately, the major difficulty of this technique is the transport across the cell membrane, normally impermeable to high-size molecules. Several techniques of molecules delivery have already been tested on corneal tissue but none of them gives results sufficiently convincing to be used in clinical applications. The aim of this thesis is to adapt and develop a new technique of intracellular molecules delivery, based on cell perforation via photoacoustic effect induced by the activation of carbon nanoparticles by femtosecond laser, on in vitro and ex vivo models of corneal endotheliu