Betulin-related esters from birch bark tar: Identification, origin and archaeological significance

Birch bark tar, an organic material frequently encountered during archaeological excavations, has been identified from its lipid composition on the cracks of a ceramic dated to the late Neolithic. Lipids of this black substance were dominated by a characteristic triterpenoid assemblage of lupane-related triterpenoids from birch bark together with their thermal degradation products formed during preparation of the tar. Among the latter, four main series of unusual triterpenoid esters have been detected and were postulated to correspond to esters of Delta2-betulin and Delta2-dihydrobetulin based on their mass spectra and hydrolysis experiments. Their conclusive identification has been achieved by synthesis of reference compounds. These compounds most likely originate from the esterification between triterpenoid alcohols related to betulin and fatty acids from suberin formed upon heating of birch bark tar. They could be considered as markers of intense heating during birch bark tar preparation using the “single pot“ procedure

Création d'un outil multimédia d'aide à la prise de charge du syndrome fémoro-patellaire

LYON1-BU Santé (693882101) / SudocSudocFranceF

Étude des liens acoustico-moteurs après cancer oral ou oropharyngé, via la réalisation d’un inventaire phonémique automatique des consonnes

National audienceIn ENT oncology, the link between anatomy and speech deficit is close, due to the impact of the pathology and its treatment on the anatomical structures involved in speech production. However, correlations between motor scores and perceptual evaluation remain weak. The use of automatic systems dedicated to phoneme recognition could lead to new results. The objective is to analyze the links between motor scores and phonemic production using an automatic phoneme recognition system applied to a pseudoword production task. After completing a phonemic inventory for each subject, the rate of occlusives recognized was significantly lower in cases of structural impairment. Compensatory mechanisms were also demonstrated, notably in the production of labiodental consonants, which was higher in cases of tongue or jaw damage.En cancérologie ORL, le lien entre anatomie et déficit de parole est étroit en raison de l’impact de la pathologie et de son traitement sur les structures anatomiques en jeu dans la production de parole. Pourtant, les corrélations entre scores moteurs et évaluation perceptive restent faibles. L’utilisation de systèmes automatiques dédiés à la reconnaissance de phonèmes pourrait permettre d’obtenir de nouveaux résultats. L’objectif est d’étudier les liens entre scores moteurs et production phonémique via un système de reconnaissance automatique de phonèmes appliqué à une tâche de production de pseudo-mots. Après réalisation d’un inventaire phonémique par sujet, le taux d’occlusives reconnues est significativement plus faible en cas d’atteinte des structures. Certains mécanismes de compensation ont également pu être mis en évidence, notamment au niveau de la production de consonnes labiodentales, plus élevée en cas d’atteinte de la langue ou de la mâchoire

Étude des liens acoustico-moteurs après cancer oral ou oropharyngé, via la réalisation d’un inventaire phonémique automatique des consonnes

National audienceIn ENT oncology, the link between anatomy and speech deficit is close, due to the impact of the pathology and its treatment on the anatomical structures involved in speech production. However, correlations between motor scores and perceptual evaluation remain weak. The use of automatic systems dedicated to phoneme recognition could lead to new results. The objective is to analyze the links between motor scores and phonemic production using an automatic phoneme recognition system applied to a pseudoword production task. After completing a phonemic inventory for each subject, the rate of occlusives recognized was significantly lower in cases of structural impairment. Compensatory mechanisms were also demonstrated, notably in the production of labiodental consonants, which was higher in cases of tongue or jaw damage.En cancérologie ORL, le lien entre anatomie et déficit de parole est étroit en raison de l’impact de la pathologie et de son traitement sur les structures anatomiques en jeu dans la production de parole. Pourtant, les corrélations entre scores moteurs et évaluation perceptive restent faibles. L’utilisation de systèmes automatiques dédiés à la reconnaissance de phonèmes pourrait permettre d’obtenir de nouveaux résultats. L’objectif est d’étudier les liens entre scores moteurs et production phonémique via un système de reconnaissance automatique de phonèmes appliqué à une tâche de production de pseudo-mots. Après réalisation d’un inventaire phonémique par sujet, le taux d’occlusives reconnues est significativement plus faible en cas d’atteinte des structures. Certains mécanismes de compensation ont également pu être mis en évidence, notamment au niveau de la production de consonnes labiodentales, plus élevée en cas d’atteinte de la langue ou de la mâchoire

Repairing the broken pots of the Late Neolithic in the South of France (3500-2300 BC). New data at the cross of functional and analytical approaches

International audienc

Malaria in French Guiana Linked to Illegal Gold Mining

International audienceno abstrac

Effects of Hormones on Breast Development and Breast Cancer Risk in Transgender Women.

Transgender women experience gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. Transgender people undergo different surgical procedures and receive sex steroids hormones to reduce psychological distress and to induce and maintain desired physical changes. These persons on feminizing hormones represent a unique population to study the hormonal effects on breast development, to evaluate the risk of breast cancer and perhaps to better understand the precise role played by different hormonal components. In MTF (male to female) patients, hormonal treatment usually consists of antiandrogens and estrogens. Exogenous hormones induce breast development with the formation of ducts and lobules and an increase in the deposition of fat. A search of the existing literature dedicated to hormone regimens for MTF patients, their impact on breast tissue (incidence and type of breast lesions) and breast cancer risk provided the available information for this review. The evaluation of breast cancer risk is currently complicated by the heterogeneity of administered treatments and a lack of long-term follow-up in the great majority of studies. Large studies with longer follow-up are required to better evaluate the breast cancer risk and to understand the precise mechanisms on breast development of each exogenous hormone

Effects of Hormones on Breast Development and Breast Cancer Risk in Transgender Women

Transgender women experience gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. Transgender people undergo different surgical procedures and receive sex steroids hormones to reduce psychological distress and to induce and maintain desired physical changes. These persons on feminizing hormones represent a unique population to study the hormonal effects on breast development, to evaluate the risk of breast cancer and perhaps to better understand the precise role played by different hormonal components. In MTF (male to female) patients, hormonal treatment usually consists of antiandrogens and estrogens. Exogenous hormones induce breast development with the formation of ducts and lobules and an increase in the deposition of fat. A search of the existing literature dedicated to hormone regimens for MTF patients, their impact on breast tissue (incidence and type of breast lesions) and breast cancer risk provided the available information for this review. The evaluation of breast cancer risk is currently complicated by the heterogeneity of administered treatments and a lack of long-term follow-up in the great majority of studies. Large studies with longer follow-up are required to better evaluate the breast cancer risk and to understand the precise mechanisms on breast development of each exogenous hormone

Detection of ESR1 mutations in matched primary and metastatic samples from endocrine-resistant lobular breast cancer patients

Poster Session 3: Tumor Cell and Moelcular Biology: Endocrine Therapy and Resistance / abstract P3-04-04info:eu-repo/semantics/nonPublishe