Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

It is well documented that the majority of adults, children and families in need of evidence-based behavioral health interventionsi do not receive them [1, 2] and that few robust empirically supported methods for implementing evidence-based practices (EBPs) exist. The Society for Implementation Research Collaboration (SIRC) represents a burgeoning effort to advance the innovation and rigor of implementation research and is uniquely focused on bringing together researchers and stakeholders committed to evaluating the implementation of complex evidence-based behavioral health interventions. Through its diverse activities and membership, SIRC aims to foster the promise of implementation research to better serve the behavioral health needs of the population by identifying rigorous, relevant, and efficient strategies that successfully transfer scientific evidence to clinical knowledge for use in real world settings [3]. SIRC began as a National Institute of Mental Health (NIMH)-funded conference series in 2010 (previously titled the “Seattle Implementation Research Conference”; $150,000 USD for 3 conferences in 2011, 2013, and 2015) with the recognition that there were multiple researchers and stakeholdersi working in parallel on innovative implementation science projects in behavioral health, but that formal channels for communicating and collaborating with one another were relatively unavailable. There was a significant need for a forum within which implementation researchers and stakeholders could learn from one another, refine approaches to science and practice, and develop an implementation research agenda using common measures, methods, and research principles to improve both the frequency and quality with which behavioral health treatment implementation is evaluated. SIRC’s membership growth is a testament to this identified need with more than 1000 members from 2011 to the present.ii SIRC’s primary objectives are to: (1) foster communication and collaboration across diverse groups, including implementation researchers, intermediariesi, as well as community stakeholders (SIRC uses the term “EBP champions” for these groups) – and to do so across multiple career levels (e.g., students, early career faculty, established investigators); and (2) enhance and disseminate rigorous measures and methodologies for implementing EBPs and evaluating EBP implementation efforts. These objectives are well aligned with Glasgow and colleagues’ [4] five core tenets deemed critical for advancing implementation science: collaboration, efficiency and speed, rigor and relevance, improved capacity, and cumulative knowledge. SIRC advances these objectives and tenets through in-person conferences, which bring together multidisciplinary implementation researchers and those implementing evidence-based behavioral health interventions in the community to share their work and create professional connections and collaborations

Convergent Demographic Effects of Insect Attack on Related Thistles in Coastal vs. Continental Dunes

Insect herbivory is common, but the conditions under which it reduces the fitness and population size of plants remain poorly understood. We quantified populationlevel impacts of floral herbivory by specialized insects on cobweb thistle (Cirsium occidentale var. occidentale) in a California coastal dune ecosystem, and then compared these demographic effects to those published for Platte thistle (Cirsium canescens) in similarly designed exclusion experiments in the continental sand dune ecosystem in the Great Plains. As a separate test of the strength of the seed-to-seedling linkage, we quantified seedling establishment rates in seed addition plots and compared these results to those obtained in herbivore exclusion experiments. This is the first test of direct vs. indirect methods of evaluating the potential impact of seed loss in plant dynamics. Floral herbivory on cobweb thistle in coastal dunes substantially reduced key components of plant fitness. Reduction of insect feeding within flower heads with insecticide increased mean per capita seed production by 144–316% and led to a 130–196% increase in cumulative seedling recruitment in the next generation, depending on dune habitat. Juvenile plant densities around insecticide-treated plants subsequently increased by \u3e50%. Both seed and flower head addition experiments corroborated the seed limitation of recruitment and juvenile plant establishment for cobweb thistle; exclusion of postdispersal seed predators did not substantially alter this relationship. While seed addition results were qualitatively similar to herbivore exclusion results, seed addition overestimated the seed–seedling transition. These results are broadly parallel to those found previously for Platte thistle in continental dunes, where reduction of insect feeding in Platte thistle flower heads increased mean per capita seed production by 37–240%, depending on year and microhabitat. This reduction in seed translated into a 33–580% increase in cumulative seedling recruitment and juvenile plant density. Thus in both systems, insect exclusions demonstrated that floral herbivory limited numbers of seeds and seedlings and population density of juvenile plants. This unique comparison of effects of insect herbivory on plant dynamics suggests that for related plants, the character and outcome of such interactions are likely to be functionally similar in structurally convergent ecosystems

Appendix A. MANOVA results showing the effect of insect reduction on per capita seed production and pod damage at Colockum Creek and Upper Dry Gulch 2003 in the foothills of the Wenatchee Mountains, Washington, USA.

MANOVA results showing the effect of insect reduction on per capita seed production and pod damage at Colockum Creek and Upper Dry Gulch 2003 in the foothills of the Wenatchee Mountains, Washington, USA

Behavioral agency theory: new foundations for theorizing about executive compensation

This article describes new micro-foundations for theorizing about executive compensation, drawing on the behavioral economics literature and based on a more realistic set of behavioral assumptions than those that have typically been made by agency theorists. We call these micro-foundations “behavioral agency theory.” In contrast to the standard agency framework, which focuses on monitoring costs and incentive alignment, behavioral agency theory places agent performance at the center of the agency model, arguing that the interests of shareholders and their agents are most likely to be aligned if executives are motivated to perform to the best of their abilities. We develop a line of argument first advanced by Wiseman and Gomez-Mejia and put the case for a more general reassessment of the behavioral assumptions underpinning agency theory. A model of economic man predicated on bounded rationality is proposed, adopting Wiseman and Gomez-Mejia’s assumptions about risk preferences, but incorporating new assumptions about time discounting, inequity aversion, and the trade-off between intrinsic and extrinsic motivation. We argue that behavioral agency theory provides a better framework for theorizing about executive compensation, an enhanced theory of agent behavior, and an improved platform for making recommendations about the design of executive compensation plans

Methodological choices of HR research conducted in Asia

A twenty-year study of the Human Resource (HR) practices-outcome relationship has found that more rigorous methodologies have been adopted over time. However, several problematic features such as cross-sectional, single-informant, and single-level designs continue to be adopted (Bainbridge et al., Human Resource Management, 2016). Responding to calls for increased contextualization of research by investigating the relationship between the location of data collection and the methodological choices of researchers, this study answers the question "How unique are the methodological choices of HR research conducted in Asia?" Applying content analysis to 241 published articles, we compare internal, external, construct and statistical conclusion validity of studies collected in North America (n=66), Europe (n=95) and Asia (n=80, including 57 studies from China). Results show that despite similarities in cross-sectional, single-informant and single-level designs across regions, research conducted in Asia is mainly undertaken via field studies, using subjective outcome measures at the organizational level, following a post-predictive design. In addition, studies from Asia are more recent, and show a shorter time gap between data collection and publication. Theoretical and practical implications embedded in the dynamic context of Asia in general, and China more specifically are discussed