9 research outputs found
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging.
BackgroundThe influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown.Methodology/principal findingsWe used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association.Conclusions/significanceOur findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined
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Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging.
BackgroundThe influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown.Methodology/principal findingsWe used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association.Conclusions/significanceOur findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined
Baseline characteristics of study participants significantly associated with African, Native American and/or European genomic ancestry (The Bambui Cohort Study of Ageing).
<p>Baseline characteristics of study participants significantly associated with African, Native American and/or European genomic ancestry (The Bambui Cohort Study of Ageing).</p
Association between individual proportion of African, Native American and European genomic ancestry levels with any major electrocardiogram abnormalities among infected with <i>Trypanosoma cruzi</i> (The Bambui-Epigen Cohort Study of Aging).
<p>Association between individual proportion of African, Native American and European genomic ancestry levels with any major electrocardiogram abnormalities among infected with <i>Trypanosoma cruzi</i> (The Bambui-Epigen Cohort Study of Aging).</p
Association between individual proportion of African, Native American and European genomic ancestry levels with <i>Trypanosoma cruzi</i> infection (The Bambui-Epigen Cohort Study of Aging).
<p>Association between individual proportion of African, Native American and European genomic ancestry levels with <i>Trypanosoma cruzi</i> infection (The Bambui-Epigen Cohort Study of Aging).</p
Association between individual proportion of Western African sub-continental genomic ancestry levels relative to total African ancestry with <i>Trypanosoma cruzi</i> infection and any major electrocardiogram abnormalities among infected (The Bambui-Epigen Cohort Study of Aging).
<p>Association between individual proportion of Western African sub-continental genomic ancestry levels relative to total African ancestry with <i>Trypanosoma cruzi</i> infection and any major electrocardiogram abnormalities among infected (The Bambui-Epigen Cohort Study of Aging).</p
Selected baseline characteristics of study participants, and by <i>Trypanosoma cruzi</i> infection (The Bambui Cohort Study of Ageing).
<p>Selected baseline characteristics of study participants, and by <i>Trypanosoma cruzi</i> infection (The Bambui Cohort Study of Ageing).</p
Hazard ratio for 15-year mortality by the presence of any major electrocardiogram abnormalities among infected with <i>Trypanosoma cruzi</i> and stratified by individual proportion of African, Native American and European ancestry levels (The Bambui-Epigen Cohort Study of Aging).
<p>Hazard ratio for 15-year mortality by the presence of any major electrocardiogram abnormalities among infected with <i>Trypanosoma cruzi</i> and stratified by individual proportion of African, Native American and European ancestry levels (The Bambui-Epigen Cohort Study of Aging).</p
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging
The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown.We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association.Our findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined