Natural Products for Salmonellosis: Last Decade Research

Salmonellosis is a disease of great relevance in terms of public health given the economic and social impact that causes both in developing and highly industrialized countries. Due to its transmission mechanism, it affects hundreds or thousands of people every year and is considered an acute disease of worldwide distribution. Causative agent of salmonellosis is salmonella specie which are small gram-negative bacilli and facultative intracellular pathogen of the Enterobacteriaceae family. Multidrug resistance is reported more frequently in strains of salmonella, raising the necessity of new strategies to combat its spread and to treat the disease. Natural products (NPs) derived from traditional medicine knowledge have become an important resource to this end. In this chapter, we present a summary of information published from 2010 to 2020, as a sample of the potentiality of NPs as agents for Salmonellosis. This search was not exhaustive, rather, we aim to obtain a random sample of information using the simplest terms on the matter of natural products for salmonellosis, hopefully, as a reference source for interested researchers

RNA Aptamer Evolution: Two Decades of SELEction

Aptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 1990, the SELEX process has become a powerful tool to select structured oligonucleotides for the recognition of targets, starting with small molecules, going through protein complexes until whole cells. SELEX has also evolved along with new technologies positioning itself as an alternative in the design of a new class of therapeutic agents in modern molecular medicine. This review is an historical follow-up of SELEX method over the two decades since its first appearance