Bioavailability and metabolism of maslinic acid, a natural pentacyclic triterpene

Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Maslinic acid is a pentacyclic triterpene found in plants used in traditional medicine with antidiabetic, antitumor, antioxidant and parasitostatic activities. A diet rich in foods of plant origin could provide a regular supply of this bioactive compound since it has been detected in olives, spinaches, eggplants, chickpeas and pomegranates. The multiple biological effects elicited by maslinic acid suggest its putative use as nutraceutical. This review summarizes our study on the safety, pharmacokinetics, and metabolism after the oral administration of maslinic acid, conducted with the aim of increasing the knowledge about the bioavailability of this bioactive food component

The fruit of Olea europaea L. as a dietary source of bioactive compounds

Podeu consultar el III Workshop anual INSA-UB complet a: http://hdl.handle.net/2445/118993Sessió 2. Pòster 1

Aplicació de la metodologia POGIL a l'aprenentatge de la fisiologia

Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524POGIL és l’acrònim de “Process Oriented Guided Inquiry Learning”. És una metodologia que encaixa amb el constructivisme: l’estudiant construeix el coneixement a partir de qüestions i tasques proposades pel professor. Una activitat POGIL consisteix en una sessió a l’aula en la que els estudiants treballen sobre un qüestionari amb activitats diverses, de forma que al final són ells mateixos els que elaboren el tema..

Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L.

Maslinic acid triggers compelling antiproliferative and pro-apoptotic effects in different human cancer cell lines. Hence, the chemopreventive activity was investigated on early stages of carcinogenesis induced by 1,2-dimethylhydrazine (DMH) which is a model that mimics human sporadic colorectal cancer. Male Sprague-Dawley rats were orally administered either maslinic acid at 5, 10 or 25 mg/kg dissolved in (2-hydroxypropyl)-β-cyclodextrin 20% (w/v) or the solvent for 49 days. After one week of treatment, animals received three weekly intraperitoneal injections of DMH at the dose of 20 mg/kg. Maslinic acid reduced the preneoplastic biomarkers, aberrant crypt foci (ACF) and mucin-depleted foci (MDF), already at 5 mg/kg in a 15% and 27%, respectively. The decline was significant at 25 mg/kg with decreases of 33% and 51%, respectively. Correlation analysis showed a significant association between the concentrations of maslinic acid found in the colon and the reduction of ACF (r = 0.999, P = 0.019) and MDF (r = 0.997, P = 0.049). The present findings demonstrate that maslinic acid induced an inhibition of the initiation stages of carcinogenesis. The assessment of this pentacyclic triterpene at the colon sheds light for designing diets with foods rich in maslinic acid to exert a chemopreventive activity in colorectal cancer

El bonus-test. Una experiència d’avaluació formativa a través del Campus virtual

La Fisiologia Humana és una assignatura comuna dels graus de Nutrició Humana i Dietètica (NHD) i de Ciència i Tecnologia dels Aliments (CTA), que es va posar en marxa el curs 2010-11. Ja des de l’inici vàrem plantejar l’avaluació de l’assignatura de forma continuada; l’objectiu és que els estudiants aprenguin continuadament. El curs incorpora activitats d’avaluació no acreditativa, per estimular l’estudi continuat i, per tant, el seguiment correcte de l’assignatura. Es tracta d’un conjunt de deu qüestionaris que es fan setmanalment a través del Campus Virtual i que aporten una bonificació a la nota final: els anomenem BONUS-TEST. Aquesta experiència l’hem portat a terme des que es va iniciar l’assignatura fins el curs actual

Face-to-face teaching: the opinion and the commitment of the students of Physiology and Pathophysiogy III in the Pharmacy Degree of the University of Barcelona

Although university teachers and students made a significant effort to adapt to a virtual scenario during the pandemic, face-to-face teaching is considered the priority system at the University of Barcelona. However, after the pandemic period, the presence of the students in the classroom has been clearly reduced. The teachers of the subject of Physiology and Pathophysiology III of the Pharmacy Degree of the University of Barcelona have designed a survey to capture the degree of satisfaction of the students about the development of face-to-face teaching tuition and to investigate their commitment to attend the classes in the classroom. The students answered this survey on the day of the final exam. The number of students in the course 2022-2023 is 313 and 95 % of them (296 students) answered the survey, which was voluntary and anonymous. In the analysis of the results obtained, we have differentiated between the students who coursed the subject for the first time (242 students) and those who failed in previous academic years and enrolled for the second or the third time (46 students). Results indicated that the students valued positively face-to-face teaching, as 94% of all the students who answered the poll rated "quiet" or "a lot" this tuition. If we consider only the students who matriculated the subject for the first time, the degree of satisfaction increased to 95% while it decreased to 90% when the students that already coursed the subject before were assessed. When they were asked about their commitment to assist the lessons at the classroom, with the question "How often have you attended the face-to-face classes?", 77% of the students answered "quite" or "a lot". Again, if we consider the students who coursed the subject for the first time, this value increased to 81% and decreased to 61% for those who were matriculated in the subject after failing it the previous year. The main reasons that they argued for not assisting to the classes were mainly 1) lack of time due to other continuous assessment exams and activities and 2) working hours. Only 1.7% of the students adduced their absence from the classroom to reasons related to the teaching quality. In conclusion, the students are in line with our university's face-to-face teaching methods, as they continue to positively value classroom teaching, despite having lived through the pandemics, when they took online classes. Their responses to the survey show us that students of the Pharmacy Degree may feel overwhelmed with the activities and exams scheduled during each term, the lack of time the reason for not attending regular face-to-face classes every day

L'estudi de casos en Fisiologia: primer esglaó cap a la Dietoteràpia

Es presenta el disseny d'activitats basades en casos perser treballades al llarg del grau de Nutrició Humana i Dietètica, seguint una progressió en el nivell competencial dels estudiants. Els casos s'iniciaran a la Fisiologia Humana de primer curs, seguint per l'Ampliació de Fisiologia Humana, fins arribar a les Patologies i Dietoteràpies de tercer. D'aquesta manera es pretén la integració de continguts, l'aprenentatge reflexiu dels estudiants i la consolidació de coneixements i capacitats

Resveratrol: A polyphenol with multiple effects

Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392trans-Resveratrol (trans-3,5,4'-trihydroxystilbene) is a natural polyphenol that occurs in grapes, berries, peanuts, and several traditional medicines. A number of studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. This review summarizes our work on the mechanisms involved in the intestinal absorption and its population pharmacokinetics. Finally, various targets of resveratrol and its therapeutic potential are described

Bioavailability and metabolism of maslinic acid, a natural pentacyclic triterpene

Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Maslinic acid is a pentacyclic triterpene found in plants used in traditional medicine with antidiabetic, antitumor, antioxidant and parasitostatic activities. A diet rich in foods of plant origin could provide a regular supply of this bioactive compound since it has been detected in olives, spinaches, eggplants, chickpeas and pomegranates. The multiple biological effects elicited by maslinic acid suggest its putative use as nutraceutical. This review summarizes our study on the safety, pharmacokinetics, and metabolism after the oral administration of maslinic acid, conducted with the aim of increasing the knowledge about the bioavailability of this bioactive food component