Sanitation and Externalities: Evidence from Early Childhood Health in Rural India

This paper estimates two sources of benefits, one direct and the other external, related to sanitation infrastructure access on early childhood health: a direct benefit a household receives when moving from open to fixed-point defecation or from unimproved sanitation to improved sanitation, and an external benefit (externality) produced by the neighborhood's access to sanitation infrastructure. Using a sample of children under 48 months in rural areas of India, it finds evidence of positive and significant direct and concave positive external effects

A high-quality genome of Eragrostis curvula grass provides insights into Poaceae evolution and supports new strategies to enhance forage quality

The Poaceae constitute a taxon of fowering plants (grasses) that cover almost all Earth?s inhabitable range and comprises some of the genera most commonly used for human and animal nutrition. Many of these crops have been sequenced, like rice, Brachypodium, maize and, more recently, wheat. Some important members are still considered orphan crops, lacking a sequenced genome, but having important traits that make them attractive for sequencing. Among these traits is apomixis, clonal reproduction by seeds, present in some members of the Poaceae like Eragrostis curvula. A de novo, high-quality genome assembly and annotation for E. curvula have been obtained by sequencing 602Mb of a diploid genotype using a strategy that combined long-read length sequencing with chromosome conformation capture. The scafold N50 for this assembly was 43.41Mb and the annotation yielded 56,469 genes. The availability of this genome assembly has allowed us to identify regions associated with forage quality and to develop strategies to sequence and assemble the complex tetraploid genotypes which harbor the apomixis control region(s). Understanding and subsequently manipulating the genetic drivers underlying apomixis could revolutionize agriculture.Fil: Carballo, José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Santos, B. A. C. M.. National Institute Of Agricultural Botany.; Reino UnidoFil: Zappacosta, Diego Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Garbus, Ingrid. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Selva, Juan Pablo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Gallo, Cristian Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Diaz, Alejandra Raquel. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. National Institute Of Agricultural Botany.; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Albertini, Emiliano. Università di Perugia; ItaliaFil: Cáccamo, Mario José. National Institute Of Agricultural Botany.; Reino UnidoFil: Echenique, Carmen Viviana. Universidad Nacional del Sur. Departamento de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentin

Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

BACKGROUND: Resveratrol is a polyphenol with important antiinflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol-induced mortality and liver lesions in mice. METHODS: Mice were randomly distributed into four groups (control, resveratrol-treated control, alcohol and resveratrol-treated alcohol). Chronic alcohol intoxication was induced by progressively administering alcohol in drinking water up to 40% v/v. The mice administered resveratrol received 10 mg/ml in drinking water. The animals had free access to standard diet. Blood levels were determined for transaminases, IL-1 and TNF-α. A histological evaluation was made of liver damage, and survival among the animals was recorded. RESULTS: Transaminase concentration was significantly higher in the alcohol group than in the rest of the groups (p < 0.05). IL-1 levels were significantly reduced in the alcohol plus resveratrol group compared with the alcohol group (p < 0.05). TNF-α was not detected in any group. Histologically, the liver lesions were more severe in the alcohol group, though no significant differences between groups were observed. Mortality in the alcohol group was 78% in the seventh week, versus 22% in the alcohol plus resveratrol group (p < 0.001). All mice in the alcohol group died before the ninth week. CONCLUSION: The results obtained suggest that resveratrol reduces mortality and liver damage in mice

International nosocomial infection control consortium (INICC) report, data summary of 36 countries, for 2004-2009

The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia). Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved

An Econometric Analysis of Sea Surface Temperatures, Sea Ice Concentrations and Ocean Surface Current Velocities

This paper analyzed quarterly longitudinal data for 64,800 1 × 1 degree grids during 2000–2019 on sea surface temperatures, sea ice concentrations, and ocean surface current zonal and meridional velocities in the Northern and Southern hemispheres. The methodological framework addressed the processing of remote sensing signals, interdependence between sea surface temperatures and sea ice concentrations, and combining zonal and meridional velocities as the eddy kinetic energy. Dynamic and static random effects models were estimated by maximum likelihood and stepwise methods, respectively, taking into account the unobserved heterogeneity across grids. The main findings were that quarterly sea surface temperatures increased steadily in the Northern hemisphere, whereas cyclical patterns were apparent in Southern hemisphere; sea ice concentrations declined in both hemispheres. Second, sea surface temperatures were estimated with large negative coefficients in the models for sea ice concentrations for the hemispheres; previous sea ice concentrations were negatively associated with sea surface temperatures, indicating feedback loops. Third, sea surface temperatures were positively and significantly associated with eddy kinetic energy in Northern hemisphere. Overall, the results indicated the importance of reducing sea surface temperatures via reductions in greenhouse gas emissions and the dumping of pollutants into oceans for maintaining sea ice concentrations and enhancing global sustainability.https://doi.org/10.3390/jmse1012185

An Econometric Analysis of Sea Surface Temperatures, Sea Ice Concentrations and Ocean Surface Current Velocities

This paper analyzed quarterly longitudinal data for 64,800 1 &times; 1 degree grids during 2000&ndash;2019 on sea surface temperatures, sea ice concentrations, and ocean surface current zonal and meridional velocities in the Northern and Southern hemispheres. The methodological framework addressed the processing of remote sensing signals, interdependence between sea surface temperatures and sea ice concentrations, and combining zonal and meridional velocities as the eddy kinetic energy. Dynamic and static random effects models were estimated by maximum likelihood and stepwise methods, respectively, taking into account the unobserved heterogeneity across grids. The main findings were that quarterly sea surface temperatures increased steadily in the Northern hemisphere, whereas cyclical patterns were apparent in Southern hemisphere; sea ice concentrations declined in both hemispheres. Second, sea surface temperatures were estimated with large negative coefficients in the models for sea ice concentrations for the hemispheres; previous sea ice concentrations were negatively associated with sea surface temperatures, indicating feedback loops. Third, sea surface temperatures were positively and significantly associated with eddy kinetic energy in Northern hemisphere. Overall, the results indicated the importance of reducing sea surface temperatures via reductions in greenhouse gas emissions and the dumping of pollutants into oceans for maintaining sea ice concentrations and enhancing global sustainability