Arctic変異型アミロイドβ蛋白によるCHRNA7機能の抑制とその分子メカニズムの解析

早大学位記番号:新7535早稲田大

Role of Λ(1670)\Lambda(1670) in the γp→K+ηΛ\gamma p \to K^+ \eta \Lambda reaction near threshold

The role of the $\Lambda(1670)$ resonance in the $\gamma p \to K^+ \eta \Lambda$ reaction near threshold is studied within an effective Lagrangian approach. We perform a calculation for the total and differential cross section of the $\gamma p \to K^+ \eta \Lambda$ reaction by including the contributions from the $\Lambda(1670)$ intermediate state decaying into $\eta \Lambda$ dominated by $K^-$ and $K^{*-}$ mesons exchanges, the nucleon pole and $N^*(1535)$ resonance decaying into $K^+ \Lambda$ dominated by exchanges of $\omega$ and $K^-$ mesons. Besides, the non-resonance process and contact terms to keep the total scattering amplitude gauge invariant are also considered. With our model parameters, the total cross section of this reaction is of the order of $1$ nanobarn at photon beam energy $E_{\gamma} \sim 2.5$ GeV. It is expected that our model predictions could be tested by future experiments.Comment: Published versio

A search for 95 GHz class I methanol masers in molecular outflows

We have observed a sample of 288 molecular outflow sources including 123 high-mass and 165 low-mass sources to search for class I methanol masers at 95 GHz transition and to investigate relationship between outflow characteristics and class I methanol maser emission with the PMO-13.7m radio telescope. Our survey detected 62 sources with 95 GHz methanol masers above 3$\sigma$ detection limit, which include 47 high-mass sources and 15 low-mass sources. Therefore the detection rate is 38% for high-mass outflow sources and 9% for low-mass outflow sources, suggesting that class I methanol maser is relatively easily excited in high-mass sources. There are 37 newly detected 95 GHz methanol masers (including 27 high-mass and 10 low-mass sources), 19 of which are newly identified (i.e. first identification) class I methanol masers (including 13 high-mass and 6 low-mass sources). Statistical analysis for the distributions of maser detections with the outflow parameters reveals that the maser detection efficiency increases with outflow properties (e.g. mass, momentum, kinetic energy and mechanical luminosity of outflows etc.). Systematic investigations of relationships between the intrinsic luminosity of methanol maser and the outflow properties (including mass, momentum, kinetic energy, bolometric luminosity and mass loss rate of central stellar sources) indicate a positive correlations. This further supports that class I methanol masers are collisionally pumped and associated with shocks, where outflows interact with the surrounding ambient medium.Comment: 32 pages, 5 figures, accepted by Ap

Genetic Algorithm with Evolutionary Chain-Based Mutation and Its Applications

Mutation is one of the important operators in genetic algorithm. In traditional genetic algorithm, mutation is activated stochastically. In this way it is unknown and cannot be controlled for which individuals to be mutated. Therefore, it is unavoidable that some good individuals are destroyed by mutation and then the evolutionary efficiency of the genetic algorithm is dampened. Owing to this kind of destructivity of mutation, the operator of mutation has to be limited within a very small probability, and the potentiality of mutation is consequently limited. In this paper, we present an evolutionary chain-based mutation and a control strategy of reasonable competition, in which the heuristic information provided by the evaluation function is well utilized. This method avoids the blindness of stochastic mutation. The performance improved in this method is shown by two examples, a fuzzy modeling for the identification of a nonlinear function and a typical combinatorial optimization problem-the traveling salesman problem

A New 95 GHz Methanol Maser Catalog: I. Data

The Purple Mountain Observatory 13.7 m radio telescope has been used to search for 95 GHz (8$_0$--7$_1$A$^+$) class I methanol masers towards 1020 Bolocam Galactic Plane Survey (BGPS) sources, leading to 213 detections. We have compared the line width of the methanol and HCO$^+$ thermal emission in all of the methanol detections and on that basis we find 205 of the 213 detections are very likely to be masers. This corresponds to an overall detection rate of 95 GHz methanol masers towards our BGPS sample of 20%. Of the 205 detected masers 144 (70%) are new discoveries. Combining our results with those of previous 95 GHz methanol masers searches, a total of four hundred and eighty-one 95 GHz methanol masers are now known, we have compiled a catalog listing the locations and properties of all known 95 GHz methanol masers.Comment: 18 pages, 7 figures, 8 tables, accepted for publication in ApJ

Linearized Tensor Renormalization Group Algorithm for Thermodynamics of Quantum Lattice Models

A linearized tensor renormalization group (LTRG) algorithm is proposed to calculate the thermodynamic properties of one-dimensional quantum lattice models, that is incorporated with the infinite time-evolving block decimation technique, and allows for treating directly the two-dimensional transfer-matrix tensor network. To illustrate its feasibility, the thermodynamic quantities of the quantum XY spin chain are calculated accurately by the LTRG, and the precision is shown to be comparable with (even better than) the transfer matrix renormalization group (TMRG) method. Unlike the TMRG scheme that can only deal with the infinite chains, the present LTRG algorithm could treat both finite and infinite systems, and may be readily extended to boson and fermion quantum lattice models.Comment: published versio

Let Graph be the Go Board: Gradient-free Node Injection Attack for Graph Neural Networks via Reinforcement Learning

Graph Neural Networks (GNNs) have drawn significant attentions over the years and been broadly applied to essential applications requiring solid robustness or vigorous security standards, such as product recommendation and user behavior modeling. Under these scenarios, exploiting GNN's vulnerabilities and further downgrading its performance become extremely incentive for adversaries. Previous attackers mainly focus on structural perturbations or node injections to the existing graphs, guided by gradients from the surrogate models. Although they deliver promising results, several limitations still exist. For the structural perturbation attack, to launch a proposed attack, adversaries need to manipulate the existing graph topology, which is impractical in most circumstances. Whereas for the node injection attack, though being more practical, current approaches require training surrogate models to simulate a white-box setting, which results in significant performance downgrade when the surrogate architecture diverges from the actual victim model. To bridge these gaps, in this paper, we study the problem of black-box node injection attack, without training a potentially misleading surrogate model. Specifically, we model the node injection attack as a Markov decision process and propose Gradient-free Graph Advantage Actor Critic, namely G2A2C, a reinforcement learning framework in the fashion of advantage actor critic. By directly querying the victim model, G2A2C learns to inject highly malicious nodes with extremely limited attacking budgets, while maintaining a similar node feature distribution. Through our comprehensive experiments over eight acknowledged benchmark datasets with different characteristics, we demonstrate the superior performance of our proposed G2A2C over the existing state-of-the-art attackers. Source code is publicly available at: https://github.com/jumxglhf/G2A2C}.Comment: AAAI 2023. v2: update acknowledgement section. arXiv admin note: substantial text overlap with arXiv:2202.0938

Gas kinematics and star formation in the filamentary molecular cloud G47.06+0.26

We performed a multi-wavelength study toward the filamentary cloud G47.06+0.26 to investigate the gas kinematics and star formation. We present the 12CO (J=1-0), 13CO (J=1-0) and C18O (J=1-0) observations of G47.06+0.26 obtained with the Purple Mountain Observation (PMO) 13.7 m radio telescope to investigate the detailed kinematics of the filament. The 12CO (J=1-0) and 13CO (J=1-0) emission of G47.06+0.26 appear to show a filamentary structure. The filament extends about 45 arcmin (58.1 pc) along the east-west direction. The mean width is about 6.8 pc, as traced by the 13CO (J=1-0) emission. G47.06+0.26 has a linear mass density of about 361.5 Msun/pc. The external pressure (due to neighboring bubbles and H II regions) may help preventing the filament from dispersing under the effects of turbulence. From the velocity-field map, we discern a velocity gradient perpendicular to G47.06+0.26. From the Bolocam Galactic Plane Survey (BGPS) catalog, we found nine BGPS sources in G47.06+0.26, that appear to these sources have sufficient mass to form massive stars. We obtained that the clump formation efficiency (CFE) is about 18% in the filament. Four infrared bubbles were found to be located in, and adjacent to, G47.06+0.26. Particularly, infrared bubble N98 shows a cometary structure. CO molecular gas adjacent to N98 also shows a very intense emission. H II regions associated with infrared bubbles can inject the energy to surrounding gas. We calculated the kinetic energy, ionization energy, and thermal energy of two H II regions in G47.06+0.26. From the GLIMPSE I catalog, we selected some Class I sources with an age of about 100000 yr, which are clustered along the filament. The feedback from the H II regions may cause the formation of a new generation of stars in filament G47.06+0.26.Comment: 10 pages, 11 figures, accepted for publication in A&

Об одном подходе к нахождению периодических решений нелинейного обычного дифференциального уравнения второго порядка

Запропоновано підхід до знаходження періодичних розв’язків нелінійного диференціального рівняння другого порядку, який базується на побудові функції Гріна для диференціального оператора, що визначений на функціях, які задовольняють періодичним крайовим умовам. Наведено необхідні та достатні умови існування періодичних розв’язків рівняння.The approach to determining of periodic solutions of the nonlinear differential second order equation is proposed. The approach is based on construction of the Green’s function for differential operator defined on the functions, which satisfy boundary conditions. Necessary and sufficient conditions for the existence of periodic solutions of the equation are shown.Предложен подход к нахождению периодических решений нелинейного дифференциального уравнения второго порядка, который базируется на построении функции Грина для дифференциального оператора, который определен на функциях, которые удовлетворяют периодическим краевым условиям. Приведено необходимые и достаточные условия существование периодических решений уравнения