Local delivery system of immune modulating drug for unresectable adenocarcinoma: in vitro experimental study and in vivo animal study

The purpose of the study was to evaluate the efficacy and safety of a developed drug delivery system containing OK-432 through in vitro and animal study

Observations Utilizing Korea Ocean Research Stations and their Applications for Process Studies

The main purposes for establishing the Korea ocean research stations (KORS) are for advancing an overall understanding of atmospheric and oceanic phenomena in the Yellow and East China Seas; for providing core scientific data for the studies on global environmental change, typhoon dynamics, biogeochemical cycles, marine ecosystems and fisheries, atmospheric chemistry involving Asian dust and aerosols, air-sea interaction processes including sea fog, and regional oceanographic process studies; and for functioning as ground stations of ocean remote sensing. Here, ocean-atmosphere time series observations with data service and case studies of KORS applications that will facilitate collaboration among researchers in the international atmospheric and oceanographic communities are presented.N

Wide-temperature-range operation of lithium-metal batteries using partially and weakly solvating liquid electrolytes

The optimal design of liquid electrolytes is vital for the build-up of long-lifespan lithium-metal batteries (LMBs) that function over a wide-temperature-range. Tuning the electrolyte solvation-structure using partially-fluorinated ether solvents and constructing stable electrode-electrolyte interfaces using electrolyte additives enhance the electrochemical reversibility of lithium-metal anodes and facilitate the realization of high-capacity cathodes for LMBs. This study reports a partially and weakly solvating electrolyte (PWSE) which enables the stable cycling of LMBs at high-voltages within a wide-temperature range through modulation of an electrolyte local-environment using a low-salt concentration of 1.3 M. 1,2-Bis(1,1,2,2-tetrafluoroethoxy)ethane contains two oxygen atoms that coordinate weakly with Li+-ions; it transforms the 1,2-dimethoxyethane-dominated electrolyte solvation-structure to a more anion-incorporated structure. Moreover, a combination of lithium fluoromalonato(difluoro)borate and silver nitrate strengthens the electrode-electrolyte interfaces and improves the oxidation durability of ether-based electrolytes. The PWSE enables the construction of 4.4 V Li|LiCoO2 full cells with a long-lifespan and high-areal-capacity of 3.12 mA h cm-2. With the aid of electrolyte additives, a partially and weakly solvating electrolyte which is acquired by controlling the local environment of the electrolyte qualifies the stable cycling of LMBs at high voltages over a wide temperature range