249 research outputs found

    Prenatal Alcohol Intake and Knowledge of its Effect: A Survey of Pregnant Women Attending a General Hospital in South East, Nigeria

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    Background: Alcohol consumption during pregnancy is a major public health concern due to its noxious effect on both the mother and fetus. Aim: The study aim was to determine the prevalence of prenatal alcohol intake, knowledge of its effects, and associated factors among pregnant women attending antenatal clinic, Poly General Hospital, Enugu. Materials and Methods: A descriptive cross‑sectional survey was adopted and simple random sampling was employed to select 248 pregnant women from the total population. Data were obtained using structured questionnaires, summarized using descriptive statistics, and presented in tables. Statistical analysis for associations between level of educational attainment, occupation of the pregnant woman, and knowledge of the effects of alcohol consumption was performed using Chi‑square tests. Results: The prevalence of alcohol use during pregnancy was 40.3% with beer (48.8%) and palm wine (48.8%) being the major alcoholic beverages taken. Majority (59.7%) of the participants had good knowledge of the effects of alcohol consumption in pregnancy while less than half (33.9%) had good knowledge of the effect on the unborn baby. Previous drinking habits before pregnancy (3.48 ± 0.84) and unwanted pregnancy (3.17 ± 0.93) were the major perceived factor influencing their alcohol intake. Educational level was not significantly related to knowledge of alcohol effects on pregnancy. Conclusion: Regardless of the knowledge of the harmful effect of alcohol on the fetus and maternal health, a significant proportion of mothers continue to consume alcohol during pregnancy. Therefore, there is a need for widespread education of women of childbearing age focused on driving behavioural change with regards to alcohol intake in pregnancy

    Evaluation of the cytotoxic potential of Securidaca longepedunculata on human breast adenocarcinoma (MCF-7) cells

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    The prevalence of cancer has increased interest in the role of complementary and alternative medicine, employing the use of plant products. Securidaca longepedunculata (SL) is an example of plant product which serves as a major component of anticancer decoctions in Nigeria. In other to scientifically ascertain this claim, this study was carried out to evaluates the cytotoxic potential of the crude extract and fractions of SL root bark against human breast adenocarcinoma (MCF-7) cell line. The root back of SL was pulverized and extracted with 80% methanol to yield a crude extract which was then submitted to liquid–liquid fractionation with dichloromethane (DCM) and butanol (BUT). The extract and fractions were subjected to Gas Chromatography-Mass Spectrometry (GC-MS). MCF-7 cell line was treated with graded concentrations (9.77 – 5000 μg ml-1) of the aqueous methanol crude extract as well as the DCM and BUT fractions for 24 or 48 hours. Cell viability was thereafter measured by XTT proliferation assay. The inhibitory activities of the aqueous methanolic crude extract was found to be both dose-dependent and time independent with IC50 values of 2241 μg ml-1 and 1808 μg ml-1 after 24 and 48 hours respectively. The DCM and BUT fractions were significantly (p < 0.05) cytotoxic with IC50 values of 86.27 μg ml-1 and 12.08 μg ml-1 respectively after 48 hours of treatment. The study provide evidence that BUT fractions of SL has the highest potential to significantly show anticancer properties

    Identifying contributors to disparities in patient access of online medical records: Examining the role of clinician encouragement

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    OBJECTIVE: The aim of this study was to understand the influence of clinician encouragement and sociodemographic factors on whether patients access online electronic medical records (EMR). MATERIALS AND METHODS: We analyzed 3279 responses from the Health Information National Trends Survey 5 cycle 4 survey, a cross-sectional, nationally representative survey administered by the National Cancer Institute. Frequencies and weighted proportions were calculated to compare clinical encouragement and access to their online EMR. Using multivariate logistic regression, we identified factors associated with online EMR use and clinician encouragement. RESULTS: In 2020, an estimated 42% of US adults accessed their online EMR and 51% were encouraged by clinicians to access their online EMR. In multivariate regression, respondents who accessed EMR were more likely to have received clinician encouragement (odds ratio [OR], 10.3; 95% confidence interval [CI], 7.7-14.0), college education or higher (OR, 1.9; 95% CI, 1.4-2.7), history of cancer (OR, 1.5; 95% CI, 1.0-2.3), and history of chronic disease (OR, 2.3; 95% CI, 1.7-3.2). Male and Hispanic respondents were less likely to have accessed EMR than female and non-Hispanic White respondents (OR, 0.6; 95% CI, 0.5-0.8, and OR, 0.5; 95% CI, 0.3-0.8, respectively). Respondents receiving encouragement from clinicians were more likely to be female (OR, 1.7; 95% CI, 1.3-2.3), have college education (OR, 1.5; 95% CI, 1.1-2.0), history of cancer (OR, 1.8; 95% CI, 1.3-2.5), and greater income levels (OR, 1.8-3.6). DISCUSSION: Clinician encouragement of patient EMR use is strongly associated with patients accessing EMR, and there are disparities in who receives clinician encouragement related to education, income, sex, and ethnicity. CONCLUSIONS: Clinicians have an important role to ensure that all patients benefit from online EMR use

    Factor analyses of a social support scale using two methods

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    Purpose: Evaluation and comparison of the factor structure of the Medical Outcomes Study Social Support Survey (MOS-SSS) using both confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) with two samples of people living with HIV/AIDS in China. Methods: Secondary analyses were conducted with data from two comparable samples of 320 people living with HIV/AIDS from the same hospital using the same inclusion criteria. The first sample of 120 was collected in 2006, and the second sample of 200 was collected in 2012. For each sample, CFA was first performed on the original four-factor structure to check model fit, followed by EFA to explore other factor structures and a subsequent CFA for model fit statistics to be compared to the original four-factor CFA. Results: In both samples, CFA on the originally hypothesized four-factor structure yielded an acceptable model fit. The EFA yielded a two-factor solution in both samples, with different items included in each factor for the two samples. Comparison of CFA on the a priori four-factor structure and the new two-factor structure in both samples indicated that both factor structures were of acceptable model fit, with the four-factor model performing slightly better than the two-factor model. Conclusion: Factor structure of the MOS-SSS is method-dependent, with CFA supporting a four-factor structure, while EFA yielded a two-factor structure in two separate samples. We need to be careful in selecting the analytic method when applying the MOS-SSS to various samples and choose the factor structure that best fits the theoretical model
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