Beam losses from ultra-peripheral nuclear collisions between Pb ions in the Large Hadron Collider and their alleviation

Electromagnetic interactions between colliding heavy ions at the Large Hadron Collider (LHC) at CERN will give rise to localized beam losses that may quench superconducting magnets, apart from contributing significantly to the luminosity decay. To quantify their impact on the operation of the collider, we have used a three-step simulation approach, which consists of optical tracking, a Monte-Carlo shower simulation and a thermal network model of the heat flow inside a magnet. We present simulation results for the case of Pb ion operation in the LHC, with focus on the ALICE interaction region, and show that the expected heat load during nominal Pb operation is 40% above the quench level. This limits the maximum achievable luminosity. Furthermore, we discuss methods of monitoring the losses and possible ways to alleviate their effect.Comment: 17 pages, 20 figure

pax1-1 partially suppresses gain-of-function mutations in Arabidopsis AXR3/IAA17

Background: The plant hormone auxin exerts many of its effects on growth and development by controlling transcription of downstream genes. The Arabidopsis gene AXR3/IAA17 encodes a member of the Aux/IAA family of auxin responsive transcriptional repressors. Semi-dominant mutations in AXR3 result in an increased amplitude of auxin responses due to hyperstabilisation of the encoded protein. The aim of this study was to identify novel genes involved in auxin signal transduction by screening for second site mutations that modify the axr3-1 gain-of-function phenotype. Results: We present the isolation of the partial suppressor of axr3-1 (pax1-1) mutant, which partially suppresses almost every aspect of the axr3-1 phenotype, and that of the weaker axr3-3 allele. axr3-1 protein turnover does not appear to be altered by pax1-1. However, expression of an AXR3:: GUS reporter is reduced in a pax1-1 background, suggesting that PAX1 positively regulates AXR3 transcription. The pax1-1 mutation also affects the phenotypes conferred by stabilising mutations in other Aux/IAA proteins; however, the interactions are more complex than with axr3-1. Conclusion: We propose that PAX1 influences auxin response via its effects on AXR3 expression and that it regulates other Aux/IAAs secondarily

First observations of beam losses due to bound-free pair production in a heavy-ion collider

We report the first observations of beam losses due to bound-free pair production at the interaction point of a heavy-ion collider. This process is expected to be a major luminosity limit for the Large Hadron Collider (LHC) when it operates with 208Pb82+ ions because the localized energy deposition by the lost ions may quench superconducting magnet coils. Measurements were performed at the Relativistic Heavy Ion Collider (RHIC) during operation with 100 GeV/nucleon 63Cu29+ ions. At RHIC, the rate, energy and magnetic field are low enough so that magnet quenching is not an issue. The hadronic showers produced when the single-electron ions struck the RHIC beampipe were observed using an array of photodiodes. The measurement confirms the order of magnitude of the theoretical cross section previously calculated by others.Comment: 4 pages, 5 figures. Added journal ref. Corrected typos. Fixed fig 1. Minor improvements to fig. 1,3,4. Rephrased a small number of sentences (p1,3,4). Added numerical values of the aperture and the displacement for Au (p 2). Changed reference 5, added name in acknowledgments (p 4

Initial evidence for the criterion-related and structural validity of the long versions of the direct and meta-perspectives of the Coach-Athlete Relationship Questionnaire

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Taylor & Francis.The aim of the present study was to develop and initially validate a longer version of the direct (Jowett & Ntoumanis, 2004) and meta-perspectives (Jowett, 2009a, 2009b) of the Coach-Athlete Relationship Questionnaire (CART-Q). In Study 1, instruments (e.g. questionnaires, scales, and inventories) that have been used to assess relationship quality in the broader psychological literature were examined and items potentially relevant to the coach-athlete relationship were identified. The content validity of the identified items was then assessed using expert panels. A final questionnaire was subsequently prepared and administered to 693 participants (310 coaches and 383 athletes). Confirmatory factor analysis was employed to assess the multidimensional nature of the questionnaire based on the 3Cs (i.e. closeness, commitment, and complementarity) model of the coach-athlete relationship. The findings indicated that the direct and meta-perspective items of the long versions of the CART-Q approached an adequate data fit. Moreover, evidence for the internal consistency and criterion validity of the new instruments was also obtained. In Study 2, the newly developed measure was administered to an independent sample of 251 individuals (145 athletes and 106 coaches). Further statistical support was gained for the factorial validity and reliability of the longer version of the CART-Q

Myth and fact in the origins of cellular life on Earth

Research into the origins of the first protocell is of a multidisciplinary nature. It draws evidence from what we know about the Earth’s early atmosphere and environment, and about the most ancient features of the cell’s structure and composition. Such data provides the input for the hypothesis generation and experimental reconstruction necessary to mimic steps in the formation of the first protocell. While research into the origins of the first protocell is condemned to focus upon laboratory experiments, it should be guided by a detailed study of real evidence pertaining to the environment on Earth 4 billion years ago. In this review, we take stock of the research that has been performed to date across the main disciplines of earth sciences, biochemistry, and molecular biology. We seek to identify the progress made in laying down a sequence for the events that led up to the first protocell. We also assess the strengths and weaknesses of the experimental designs and suggest some future approaches. While the field has made many important advances, from the original Stanley Miller experiment establishing ‘life from chemistry’ products such as amino acids, through to Deamer’s findings on fatty acid membranes and Szostack’s work on lipids, there is still a long and challenging journey ahead to understand how cellular life began. The experiments required to make more rapid progress in the field will likely be more elaborate, costly, and time consuming

Attachment Styles Within the Coach-Athlete Dyad: Preliminary Investigation and Assessment Development

The present preliminary study aimed to develop and examine the psychometric properties of a new sport-specific self-report instrument designed to assess athletes’ and coaches’ attachment styles. The development and initial validation comprised three main phases. In Phase 1, a pool of items was generated based on pre-existing self-report attachment instruments, modified to reflect a coach and an athlete’s style of attachment. In Phase 2, the content validity of the items was assessed by a panel of experts. A final scale was developed and administered to 405 coaches and 298 athletes (N = 703 participants). In Phase 3, confirmatory factor analysis of the obtained data was conducted to determine the final items of the Coach-Athlete Attachment Scale (CAAS). Confirmatory factor analysis revealed acceptable goodness of fit indexes for a 3-first order factor model as well as a 2-first order factor model for both the athlete and the coach data, respectively. A secure attachment style positively predicted relationship satisfaction, while an insecure attachment style was a negative predictor of relationship satisfaction. The CAAS revealed initial psychometric properties of content, factorial, and predictive validity, as well as reliability

Do Economic Evaluations in Primary Care Prevention and the Management of Hypertension Conform to Good Practice Guidelines? A Systematic Review

Background: Results of previous research have identified the need for further investigation into the compliance with good practice guidelines for current decision-analytic modeling (DAM). Objective: To identify the extent to which recent model-based economic evaluations of interventions focused on lowering the blood pressure (BP) of patients with hypertension conform to published guidelines for DAM in health care using a five-dimension framework developed to assess compliance to DAM guidelines. Methods: A systematic review of English language articles was undertaken to identify published model-based economic evaluations that examined interventions aimed at lowering BP. The review covered the period January 2000 to March 2015 and included the following electronic bibliographic databases: EMBASE and Medline via Ovid interface and the Centre for Reviews and Dissemination’s (CRD) NHS-EED. Data were extracted based on different components of good practice across five dimensions utilizing a framework to assess compliance to DAM guidelines. Results: Thirteen articles were included in this review. The review found limited compliance to good practice DAM guidelines, which was most frequently justified by the lack of data. Conclusions: The assessment of structural uncertainty cannot yet be considered common practice in primary prevention and management of hypertension, and researchers seem to face difficulties with identifying sources of structural uncertainty and then handling them correctly. Additional guidelines are needed to aid researchers in identifying and managing sources of potential structural uncertainty. Adherence to guidelines is not always possible and it does pose challenges, in particular when there are limitations due to data availability that restrict, for example, a validation process

Perfectionism in Sport, Dance, and Exercise

Perfect performance, flawlessness, and the perfect body are revered in sport, dance, and exercise. As such, sport, dance, and exercise provide ideal domains in which to study perfectionism. This chapter provides an overview of research that has examined multidimensional perfectionism in these domains. We place particular emphasis on the most recent research in this area and provide suggestions to guide future research. It will be argued that perfectionism is a complex characteristic with particular relevance in sport, dance, and exercise. In addition, in its various guises, perfectionism can be problematic, beneficial, and also ambivalent with regards to motivation, well-being, and performance. To better understand the effects of perfectionism in sport, dance, and exercise, we call for research that adopts longitudinal designs, examines moderating factors, develops and refines measurement tools, and focuses on the influence of perfectionism among exercisers

A new spatially and temporally variable sigma parameter in degree-day melt modelling of the Greenland Ice Sheet 1870–2013

The degree-day based method of calculating ice-/snow-melt across the Greenland Ice Sheet (GrIS) commonly includes the temperature parameter sigma (σ) accounting for temperature variability on short (sub-monthly down to hourly) timescales, in order to capture melt in months where the mean temperature is below 0 °C. Sigma is typically assumed to be constant in space and time, with values ranging from ~ 2.5 to 5.5 °C. It is unclear in many cases how these values were derived and little sensitivity analysis or validation has been conducted. Here we determine spatially and temporally varying monthly values of σ for the unique, extended 1870–2013 timescale based on downscaled, corrected European Centre for Medium-Range Weather Forecasts (ECMWF) Interim (ERA-I) and Twentieth Century Reanalysis (20CR) meteorological reanalysis 2 m air temperatures on a 5 km × 5 km polar stereographic grid for the GrIS. The resulting monthly σ values reveal a distinct seasonal cycle. The mean summer σ value for the study period is ~ 3.2 °C, around 1 °C lower than the value of 4.2 °C commonly used in the literature. Sigma values for individual summers range from 1.7 to 5.9 °C. Since the summer months dominate the melt calculation, use of the new variable σ parameter would lead to a smaller melt area and a more positive surface mass balance for the GrIS. Validation of our new variable σ dataset shows good agreement with standard deviations calculated from automatic weather station observations across the ice sheet. Trend analysis shows large areas of the ice sheet exhibit statistically significant increasing temperature variability from 1870–2013 in all seasons, with notable exceptions around Summit in spring, and Summit and South Dome in winter. More recently, since 1990, σ has been decreasing, significantly so in the north-west during July. These interannual σ trends reflect climate change and variability processes operating across the ice sheet, several mechanisms of which are briefly discussed