L'efecte de l'ús de la força sobre les actituds cap a la policia. El cas de l’1-O de 2017 a Catalunya

Treballs finals del Màster en Análisi Política i Assessoria Institucional, Facultat de Dret, Universitat de Barcelona. Curs: 2020-2021. Tutor: Falcó Gimeno, Alber

Valoración de los docentes de educación física de las actividades deportivas extraescolares

El objetivo de este trabajo fue analizar el conocimiento de los profesores hacia las actividades deportivas extraescolares. He mos utilizado un cuestionario. La muestra fue de 30 docentes especialistas en Educaci ón Física de primaria, y tras diversos análisis descriptivos, de varianza y prueb as de independencia entre variables, las principales conclusiones a las que h emos llegado han sido que, los profesores: dan mucha importancia a las actividades deportivas extraescolares; están de acuerdo en que la práctica de actividades extraescolares es básica para conseguir un estado saludable; piensan que la compe tencia profesional de los monitores es fundamental para la calidad educativa de las actividades y, la mayoría, no participa en la programación y diseño d e las actividades extra- escolares. Por tanto, es fundamental establecer una s vías de comunicación entre los agentes implicados en las actividades extraescolare s con el fin de mejorar la calidad de las mismas

Normal faulting in the 1923 Berdún earthquake and postorogenic extension in the Pyrenees

The 10 July 1923 earthquake near Berdún (Spain) is the largest instrumentally recorded event in the Pyrenees. We recover old analog seismograms and use 20 hand-digitized waveforms for regional moment tensor inversion. We estimate moment magnitude Mw 5.4, centroid depth of 8 km, and a pure normal faulting source with strike parallel to the mountain chain (N292°E), dip of 66° and rake of -88°. The new mechanism fits into the general predominance of normal faulting in the Pyrenees and extension inferred from Global Positioning System data. The unique location of the 1923 earthquake, near the south Pyrenean thrust front, shows that the extensional regime is not confined to the axial zone where high topography and the crustal root are located. Together with seismicity near the northern mountain front, this indicates that gravitational potential energy in the western Pyrenees is not extracted locally but induces a wide distribution of postorogenic deformation.Peer ReviewedPostprint (published version

A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli.

Metal limitation is a common situation during infection and can have profound effects on the pathogen's success. In this report, we examine the role of zinc limitation in the expression of a virulence factor in uropathogenic Escherichia coli. The pyelonephritis isolate J96 carries two hlyCABD operons that encode the RTX toxin α-hemolysin. While the coding regions of both operons are largely conserved, the upstream sequences, including the promoters, are unrelated. We show here that the two hlyCABD operons are differently regulated. The hly II operon is efficiently silenced in the presence of zinc and highly expressed when zinc is limited. In contrast, the hly I operon does not respond to zinc limitation. Genetic studies reveal that zinc-responsive regulation of the hly II operon is controlled by the Zur metalloregulatory protein. A Zur binding site was identified in the promoter sequence of the hly II operon, and we observe direct binding of Zur to this promoter region. Moreover, we find that Zur regulation of the hly II operon modulates the ability of E. coli J96 to induce a cytotoxic response in host cell lines in culture. Our report constitutes the first description of the involvement of the zinc-sensing protein Zur in directly modulating the expression of a virulence factor in bacteria

Up-Regulation of Specific Bioactive Lipids in Celiac Disease

Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome of CD subjects have been documented. We engage in a metabolomic study that analyzes plasma metabolome in 17 children with CD treated with a gluten-free diet and 17 healthy control siblings in order to recognize potential changes in metabolic networks. Our data demonstrates the persistence of metabolic defects in CD subjects in spite of the dietary treatment, affecting a minor but significant fraction (around 4%, 209 out of 4893 molecular features) of the analyzed plasma metabolome. The affected molecular species are mainly, but not exclusively, lipid species with a particular affectation of steroids and derivatives (indicating an adrenal gland affectation), glycerophospholipids (to highlight phosphatidic acid), glycerolipids (with a special affectation of diacylglycerols), and fatty acyls (eicosanoids). Our findings are suggestive of an activation of the diacylglycerol-phosphatidic acid signaling pathway in CD that may potentially have detrimental effects via activation of several targets including protein kinases such as mTOR, which could be the basis of the morbidity and mortality connected with untreated CD. However, more studies are necessary to validate this idea regarding CD.Regional Government of Andalusia, Excellence Research (Project No P12-AGR-2581)Spanish Ministry of Science, Innovation, and Universities (Ministerio de Ciencia, Innovación y Universidades, RTI2018-099200-BI00)Generalitat of Catalonia: Agency for Management of University and Research Grants (2017SGR696)Department of Health (SLT002/16/00250)FEDER - European Union (“A way to build Europe”).IRBLleida - CERCA Programme/Generalitat of Catalonia“Investigation grant program by the Association of Celiacs and Sensitive to Gluten of the Community of Madri