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    Hydration of hyaluronic acid as a function of the counterion type and relative humidity

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    cited By 33International audienceThe form of water associated with different ionic and physical forms of hyaluronic acid was investigated primarily using differential scanning calorimetry. The amount of non-freezable water associated with the polysaccharide was about 0.7g H2O/g dry solids which corresponded to 15 water molecules per disaccharide unit. This value depended slightly on the physical form of the material (powder, film or freeze-dried material) and also on the ionic form. The physical properties of a hyaluronic acid film showed a transition around a relative humidity of 88% when freezable water starts to be observed. © 1995
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