Extradural haematoma of the posterior fossa

No Abstrac

A review of hydatid disease of the brain

No Abstrac

Simulation as an educational strategy to deliver interprofessional education

Background. Various educational methods are available to deliver interprofessional education (IPE) to prepare healthcare students for collaborative practice. One such method is simulation-based health education.Objectives. To identify current IPE methods used in undergraduate programmes in the Faculty of Health Sciences at the University of the Free State, Bloemfontein, South Africa, and to determine the opinions of module leaders on using simulation as a particular IPE teaching strategy.Methods. A quantitative, cross-sectional descriptive study design was employed. Structured interviews were conducted with 47 module leaders of the undergraduate programmes in the Faculty of Health Sciences. These programmes cover 66 modules in the Schools for Allied Health Professions (nutrition and dietetics, occupational therapy, physiotherapy and optometry), nursing and medicine.Results. At the time of the study, IPE activities were used in 29 (43.9%) of the modules, of which 17 (58.6%) were coincidental.  Respondents’ opinions on the potential use of simulation to address formalised IPE activities included the challenge of ‘scheduling’ (73.9%) and ‘logistical and high cost issues’ (19.6%). The most prominent advantage that was foreseen (41.3%) was better clarification of roles among the different professions.Conclusions. The module leaders had a positive attitude towards simulation and its potential use for IPE, with their major concern being logistical challenges. To improve role clarification, a scenario should be developed to engage students from all the relevant professions. The proposed type of simulation was to use standardised patients in a role-play scenario. The outcomes of these activities should be aligned with the principles of IPE

An Audit of the Use of Regional Anaesthesia for Caesarean Section in the Free State: from 2002 to 2004

Regional anaesthesia (RA) is associated with a lower mortality than general anaesthesia (GA) for obstetric anaesthesia. Accordingly, the Saving Mothers Report 1999-2001 proposed that 75% of Caesarean section (CS) should be performed under RA.2 An initial audit found that in the Free State, 71% of CS’s were performed under RA in 2002. Various educational interventions promoting the use of RA for CS were then instituted and the audit repeated for 2004, to determine whether there had been any change in the use of RA for CS’s from 2002 to 2004 and the 75% target achieved

Haematological condition of the San (Bushmen) relocated from Namibia to South Africa

No Abstract

Variation in the inter-service intervals of UK dairy cows

An understanding of the normal estrous cycle length of the cow is important when managing and monitoring dairy herd fertility. Whilst the normal inter-ovulatory interval is widely considered to be 21 days, some studies have found alternative intervals to be more prevalent; previously most of the variation in interval length was expected to be between cows. The aim of this study was to assess the time between inseminations (inter-service interval, ISI), in a large number of dairy cows and to explore possible associations between cow factors and estrous cycle length. The study used ISI data from 42,252 cows in 159 herds across England and Wales. Univariate analysis of the subset of 114,572 intervals between 15 and 30 days (a range covering the increased frequency of ISIs occurring at the expected time of the first return to estrus) following an insemination revealed a modal ISI of 22 days. Primiparous heifers had a modal ISI of 21 days. There were significant differences between the distribution of ISIs for different yield groups, parity numbers and the number of inseminations. Multilevel regression modelling was used to evaluate the associations between cow factors and ISI, whilst accounting for clustering at the herd and cow level. This revealed significant associations between predicted ISI and insemination number, days in milk, lactation 305 day milk yield, and month and year of insemination. Variance partition coefficients indicated that only 1% of variation in ISIs was at the herd level, 12% at the animal level and 87% at the insemination level, indicating that cycle length varies substantially more between cycles within a cow than between cows or herds. These findings suggest the “normal” range of ISI for modern UK dairy cows is longer than expected and that there is a large amount of unexplained variation in cycle length within individual animals over time

Break-taking behaviour pattern of long-distance freight vehicles based on GPS trajectory data

This paper focuses on the break-taking behaviour pattern of long-distance freight vehicles, providing a new perspective on the study of behaviour patterns and simultaneously providing a reference for transport management departments and related enterprises. Based on Global Positioning System (GPS) trajectory data, we select stopping points as break-taking sites of long-distance freight vehicles and then classify the stopping points into three different classes based on the break-taking duration. We then explore the relationship of the distribution of the break-taking frequency between the three single classifications and their combinations, on the basis of the break-taking duration distribution. We find that the combination is a Gaussian distribution when each of the three individual classes is a Gaussian distribution, contrasting with the power-law distribution of the break-taking duration. Then we experimental analysis the distribution of the break-taking durations and frequencies, and find that, for the durations, the three single classifications can be fitted individually by an Exponential distribution and together by a Power-law distribution, for the frequencies, both the three single classifications and together can be fitted by a Gaussian distribution,so that can validate the above theoretical analysis. Key words: break-taking behaviour, long-distance freight vehicle, statistical analysi

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. We examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina" s HumanMethyl450 Beadchip in 1,988 newborns from two European cohorts. Here we report the combined covariate-adjusted results using meta-analysis and employ pathway and gene expression analyses. Four-hundred forty-three CpGs (320 genes) are significantly associated with maternal plasma folate levels during pregnancy (false discovery rate 5%); 48 are significant after Bonferroni correction. Most genes are not known for folate biology, including APC2, GRM8, SLC16A12, OPCML, PRPH, LHX1, KLK4 and PRSS21. Some relate to birth defects other than neural tube defects, neurological functions or varied aspects of embryonic development. These findings may inform how maternal folate impacts the developing epigenome and health outcomes in offspring

High-Accuracy X-Ray Diffraction Analysis of Phase Evolution Sequence During Devitrification of Cu50Zr50 Metallic Glass

Real-time high-energy X-ray diffraction (HEXRD) was used to investigate the crystallization kinetics and phase selection sequence for constant-heating-rate devitrification of fully amorphous Cu50Zr50, using heating rates from 10 K/min to 60 K/min (10 °C/min to 60 °C/min). In situ HEXRD patterns were obtained by the constant-rate heating of melt-spun ribbons under synchrotron radiation. High-accuracy phase identification and quantitative assessment of phase fraction evolution though the duration of the observed transformations were performed using a Rietveld refinement method. Results for 10 K/min (10 °C/min) heating show the apparent simultaneous formation of three phases, orthorhombic Cu10Zr7, tetragonal CuZr2 (C11b), and cubic CuZr (B2), at 706 K (433 °C), followed immediately by the dissolution of the CuZr (B2) phase upon continued heating to 789 K (516 °C). Continued heating results in reprecipitation of the CuZr (B2) phase at 1002 K (729 °C), with the material transforming completely to CuZr (B2) by 1045 K (772 °C). The Cu5Zr8 phase, previously reported to be a devitrification product in C50Zr50, was not observed in the present study