2,074 research outputs found
Matrix multiplication using quantum-dot cellular automata to implement conventional microelectronics
Quantum-dot cellular automata (QCA) shows promise as a post silicon CMOS, low
power computational technology. Nevertheless, to generalize QCA for
next-generation digital devices, the ability to implement conventional
programmable circuits based on NOR, AND, and OR gates is necessary. To this
end, we devise a new QCA structure, the QCA matrix multiplier (MM), employing
the standard Coulomb blocked, five quantum dot (QD) QCA cell and
quasi-adiabatic switching for sequential data latching in the QCA cells. Our
structure can multiply two N x M matrices, using one input and one
bidirectional input/output data line. The calculation is highly parallelizable,
and it is possible to achieve reduced calculation time in exchange for
increasing numbers of parallel matrix multiplier units. We show convergent, ab
initio simulation results using the Intercellular Hartree Approximation for
one, three, and nine matrix multiplier units. The structure can generally
implement any programmable logic array (PLA) or any matrix multiplication based
operation.Comment: 14 pages, 9 figures, supplemental informatio
Multi-color Optical and NIR Light Curves of 64 Stripped-Envelope Core-Collapse Supernovae
We present a densely-sampled, homogeneous set of light curves of 64 low
redshift (z < 0.05) stripped-envelope supernovae (SN of type IIb, Ib, Ic and
Ic-bl). These data were obtained between 2001 and 2009 at the Fred L. Whipple
Observatory (FLWO) on Mt. Hopkins in Arizona, with the optical FLWO 1.2-m and
the near-infrared PAIRITEL 1.3-m telescopes. Our dataset consists of 4543
optical photometric measurements on 61 SN, including a combination of UBVRI,
UBVr'i', and u'BVr'i', and 2142 JHKs near-infrared measurements on 25 SN. This
sample constitutes the most extensive multi-color data set of stripped-envelope
SN to date. Our photometry is based on template-subtracted images to eliminate
any potential host galaxy light contamination. This work presents these
photometric data, compares them with data in the literature, and estimates
basic statistical quantities: date of maximum, color, and photometric
properties. We identify promising color trends that may permit the
identification of stripped-envelope SN subtypes from their photometry alone.
Many of these SN were observed spectroscopically by the CfA SN group, and the
spectra are presented in a companion paper (Modjaz et al. 2014). A thorough
exploration that combines the CfA photometry and spectroscopy of
stripped-envelope core-collapse SN will be presented in a follow-up paper.Comment: 26 pages, 17 figures, 8 tables. Revised version resubmitted to ApJ
Supplements after referee report. Additional online material is available
through http://cosmo.nyu.edu/SNYU
IVUmed: A Nonprofit Model for Surgical Training in Low-Resource Countries
Background: Low- and middle-income countries (LMICs) face both training and infrastructural challenges for surgical care, particularly for specialty care, such as for urology. Practitioners charged with caring for these patients have few options for basic or advanced training. Objectives: IVUmed, a nonprofit organization, has for 20 years supported urological educational programs in 30 LMICs by coordinating a network of US and international academic and private providers, institutions, industry partners, and professional societies. Methods: IVUmed's motto, “Teach One, Reach Many” has emphasized a teach-the-teacher approach. Program partners, such as Hopital General de Grand Yoff in Dakar, Senegal, have advanced from little urological subspecialty availability to having the capacity to treat a wide range of conditions while also teaching surgeons from Senegal and neighboring countries. Conclusions: Long-term program commitments; effective communication; and a shared vision among the program site, the coordinating nongovernmental organization, and supporting organizations facilitate the development of thriving surgical teaching programs capable of serving local communities and conducting outreach training
CfAIR2: Near Infrared Light Curves of 94 Type Ia Supernovae
CfAIR2 is a large homogeneously reduced set of near-infrared (NIR) light
curves for Type Ia supernovae (SN Ia) obtained with the 1.3m Peters Automated
InfraRed Imaging TELescope (PAIRITEL). This data set includes 4607 measurements
of 94 SN Ia and 4 additional SN Iax observed from 2005-2011 at the Fred
Lawrence Whipple Observatory on Mount Hopkins, Arizona. CfAIR2 includes JHKs
photometric measurements for 88 normal and 6 spectroscopically peculiar SN Ia
in the nearby universe, with a median redshift of z~0.021 for the normal SN Ia.
CfAIR2 data span the range from -13 days to +127 days from B-band maximum. More
than half of the light curves begin before the time of maximum and the coverage
typically contains ~13-18 epochs of observation, depending on the filter. We
present extensive tests that verify the fidelity of the CfAIR2 data pipeline,
including comparison to the excellent data of the Carnegie Supernova Project.
CfAIR2 contributes to a firm local anchor for supernova cosmology studies in
the NIR. Because SN Ia are more nearly standard candles in the NIR and are less
vulnerable to the vexing problems of extinction by dust, CfAIR2 will help the
supernova cosmology community develop more precise and accurate extragalactic
distance probes to improve our knowledge of cosmological parameters, including
dark energy and its potential time variation.Comment: 31 pages, 15 figures, 10 tables. Accepted to ApJS. v2 modified to
more closely match journal versio
Testing Models of Intrinsic Brightness Variations in Type Ia Supernovae, and their Impact on Measuring Cosmological Parameters
For spectroscopically confirmed Type Ia supernovae we evaluate models of
intrinsic brightness variations with detailed data/Monte Carlo comparisons of
the dispersion in the following quantities: Hubble-diagram scatter, color
difference (B-V-c) between the true B-V color and the fitted color (c) from the
SALT-II light curve model, and photometric redshift residual. The data sample
includes 251 ugriz light curves from the 3-season Sloan Digital Sky Survey-II,
and 191 griz light curves from the Supernova Legacy Survey 3-year data release.
We find that the simplest model of a wavelength-independent (coherent) scatter
is not adequate, and that to describe the data the intrinsic scatter model must
have wavelength-dependent variations. We use Monte Carlo simulations to examine
the standard approach of adding a coherent scatter term in quadrature to the
distance-modulus uncertainty in order to bring the reduced chi2 to unity when
fitting a Hubble diagram. If the light curve fits include model uncertainties
with the correct wavelength dependence of the scatter, we find that the bias on
the dark energy equation of state parameter is negligible. However,
incorrect model uncertainties can lead to a significant bias on the distance
moduli, with up to ~0.05 mag redshift-dependent variation. For the recent SNLS3
cosmology results we estimate that this effect introduces an additional
systematic uncertainty on of ~0.02, well below the total uncertainty.
However, this uncertainty depends on the samples used, and thus this small
-uncertainty is not guaranteed in future cosmology results.Comment: accepted by Ap
High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility
Transcriptional regulators lacking enzymatic activity or binding pockets with targetable molecular features have typically been considered “undruggable,” and a reductionist approach based on identification of their molecular targets has largely failed. We have demonstrated that the Ewing sarcoma chimeric transcription factor, EWSR1-FLI1, maintains accessible chromatin at disease-specific regions. We adapted formaldehyde-assisted isolation of regulatory elements (FAIRE), an assay for accessible chromatin, to screen an epigenetically targeted small molecule library for compounds that reverse the disease-associated signature. This approach can be applied broadly for discovery of chromatin-based developmental therapeutics and offers significant advantages because it does not require the selection of a single molecular target. Using this approach, we identified a specific class of compounds with therapeutic potential
Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: A 4-wk randomized controlled crossover trial
Background - Emerging evidence suggests that increasing intakes of nitrate-rich vegetables may be an effective approach to reduce blood pressure.
Objective - Our primary aim was to determine whether daily consumption of nitrate-rich vegetables over 4 wk would result in lower blood pressure.
Design - Thirty participants with prehypertension or untreated grade 1 hypertension were recruited to a randomized controlled crossover trial with 4-wk treatment periods separated by 4-wk washout periods. Participants completed 3 treatments in random order: 1) increased intake (∼200 g/d) of nitrate-rich vegetables [high-nitrate (HN); ∼150 mg nitrate/d], 2) increased intake (∼200 g/d) of nitrate-poor vegetables [low-nitrate (LN); ∼22 mg nitrate/d], and 3) no increase in vegetables (control; ∼6 mg nitrate/d). Compliance was assessed with the use of food diaries and by measuring plasma nitrate and carotenoids. Nitrate metabolism was assessed with the use of plasma, salivary, and urinary nitrate and nitrite concentrations. The primary outcome was blood pressure assessed by using 24-h ambulatory, home, and clinic measurements. Secondary outcomes included measures of arterial stiffness.
Results - Plasma nitrate and nitrite concentrations increased with the HN treatment in comparison to the LN and control treatments (P \u3c 0.001). Plasma carotenoids increased with the HN and LN treatments compared with the control (P \u3c 0.01). HN treatment did not reduce systolic blood pressure [24-h ambulatory—HN: 127.4 ± 1.1 mm Hg; LN: 128.6 ± 1.1 mm Hg; control: 126.2 ± 1.1 mm Hg (P = 0.20); home—HN: 127.4 ± 0.7 mm Hg; LN: 128.7 ± 0.7 mm Hg; control: 128.3 ± 0.7 mm Hg (P = 0.36); clinic—HN: 128.4 ± 1.3 mm Hg; LN: 130.3 ± 1.3 mm Hg; control: 129.8 ± 1.3 mm Hg (P = 0.49)] or diastolic blood pressure compared with LN and control treatments (P \u3e 0.05) after adjustment for pretreatment values, treatment period, and treatment order. Similarly, no differences were observed between treatments for arterial stiffness measures (P \u3e 0.05).
Conclusion - Increased intake of nitrate-rich vegetables did not lower blood pressure in prehypertensive or untreated grade 1 hypertensive individuals when compared with increased intake of nitrate-poor vegetables and no increase in vegetables
Compact HI clouds from the GALFA-HI survey
The Galactic Arecibo L-band Feed Array HI (GALFA-HI) survey is mapping the
entire Arecibo sky at 21-cm, over a velocity range of -700 to +700 km/s (LSR),
at a velocity resolution of 0.18 km/s and a spatial resolution of 3.5 arcmin.
The unprecedented resolution and sensitivity of the GALFA-HI survey have
resulted in the detection of numerous isolated, very compact HI clouds at low
Galactic velocities, which are distinctly separated from the HI disk emission.
In the limited area of ~4600 deg surveyed so far, we have detected 96 of
such compact clouds. The detected clouds are cold with a median T
(the kinetic temperature in the case in which there is no non-thermal
broadening) of 300 K. Moreover, these clouds are quite compact and faint, with
median values of 5 arcmin in angular size, 0.75 K in peak brightness
temperature, and cm in HI column density. Most of the
clouds deviate from Galactic rotation at the 20-30 km/s level, and a
significant fraction show evidence for a multiphase medium and velocity
gradients. No counterparts for these clouds were found in other wavebands. From
the modeling of spatial and velocity distributions of the whole compact cloud
population, we find that the bulk of the compact clouds are related to the
Galactic disk, and their distances are likely to be in the range of 0.1 to a
few kpc. We discuss various possible scenarios for the formation and
maintenance of this cloud population and its significance for Galactic ISM
studies.Comment: Accepted for publication in the Astrophysical Journa
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