2,456 research outputs found
Coherent Cancellation of Photothermal Noise in GaAs/AlGaAs Bragg Mirrors
Thermal noise is a limiting factor in many high-precision optical
experiments. A search is underway for novel optical materials with reduced
thermal noise. One such pair of materials, gallium arsenide and
aluminum-alloyed gallium arsenide (collectively referred to as AlGaAs), shows
promise for its low Brownian noise when compared to conventional materials such
as silica and tantala. However, AlGaAs has the potential to produce a high
level of thermo-optic noise. We have fabricated a set of AlGaAs crystalline
coatings, transferred to fused silica substrates, whose layer structure has
been optimized to reduce thermo-optic noise by inducing coherent cancellation
of the thermoelastic and thermorefractive effects. By measuring the
photothermal transfer function of these mirrors, we find evidence that this
optimization has been successful.Comment: 10 pages, 7 figure
High-Resolution Measurements of the Dark Matter Halo of NGC 2976: Evidence for a Shallow Density Profile
We have obtained two-dimensional velocity fields of the dwarf spiral galaxy
NGC 2976 in Halpha and CO. The high spatial (~75 pc) and spectral (13 km/s and
2 km/s, respectively) resolution of these observations, along with our
multicolor optical and near-infrared imaging, allow us to measure the shape of
the density profile of the dark matter halo with good precision. We find that
the total (baryonic plus dark matter) mass distribution of NGC 2976 follows a
rho_tot ~ r^(-0.27 +/- 0.09) power law out to a radius of 1.8 kpc, assuming
that the observed radial motions provide no support. The density profile
attributed to the dark halo is even shallower, consistent with a nearly
constant density of dark matter over the entire observed region. A maximal disk
fit yields an upper limit to the K-band stellar mass-to-light ratio (M*/L_K) of
0.09^{+0.15}_{-0.08} M_sun/L_sun,K (including systematic uncertainties), with
the caveat that for M*/L_K > 0.19 M_sun/L_sun,K the dark matter density
increases with radius, which is unphysical. Assuming 0.10 M_sun/L_sun,K <
M*/L_K < 0.19 M_sun/L_sun,K, the dark matter density profile lies between
rho_dm ~ r^-0.17 and rho_dm ~ r^-0.01. Therefore, independent of any
assumptions about the stellar disk or the functional form of the density
profile, NGC 2976 does not contain a cuspy dark matter halo. We also
investigate some of the systematic effects that can hamper rotation curve
studies, and show that 1) longslit rotation curves are far more vulnerable to
systematic errors than two-dimensional velocity fields, 2) NGC 2976 contains
large radial motions at small radii, and 3) the Halpha and CO velocity fields
of NGC 2976 agree within their uncertainties. [slightly abridged]Comment: 30 pages, 4 tables, 13 figures (7 in color; Figures 1 and 3 are
low-resolution to save space). Accepted for publication in ApJ. Version with
full-resolution figures available at
http://astro.berkeley.edu/~bolatto/ngc2976rotation.ps (46 MB
An interleaved sampling scheme for the characterization of single qubit dynamics
In this paper, we demonstrate that interleaved sampling techniques can be
used to characterize the Hamiltonian of a qubit and its environmental
decoherence rate. The technique offers a significant advantage in terms of the
number of measurements that are required to characterize a qubit. When compared
to the standard Nyquist-Shannon sampling rate, the saving in the total
measurement time for the interleaved method is approximately proportional to
the ratio of the sample rates.Comment: 9 pages, 4 figure
Concert recording 2021-11-15
[Track 1] Growth / Cole Powledge -- [Track 2] Day tripper ; Lady Madonna / Lennon/McCartney ; arranged by Tommy Emmanuel -- [Track 3] Disappear / Joshua Larson -- [Track 4] Sirabhorn / Pat Metheny -- [Track 5] Parisienne walkways / Gary Moore -- [Track 6] Songbird / Kenny G -- [Track 7] Drifting / Cody Lucas -- [Track 8] Slow dancing in a burning room / John Mayer -- [Track 9] Suites of morning
Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate. Inactivation of heparan sulfate uronyl 2-O-sulfotransferase (Hs2st) in neutrophils substantially reduced their bactericidal activity, and Hs2st deficiency rendered mice more susceptible to systemic infection with the pathogenic bacterium group B Streptococcus. Specifically, altered sulfation of heparan sulfate in mutant neutrophils affected formation of neutrophil extracellular traps while not influencing phagocytosis, production of reactive oxygen species, or secretion of granular proteases. Heparan sulfate proteoglycan(s) is present in neutrophil extracellular traps, modulates histone affinity, and modulates their microbial activity. Hs2st-deficient brain endothelial cells show enhanced binding to group B Streptococcus and are more susceptible to apoptosis, likely contributing to the observed increase in dissemination of group B Streptococcus into the brain of Hs2st-deficient mice following intravenous challenge. Taken together, our data provide strong evidence that heparan sulfate from both neutrophils and the endothelium plays important roles in modulating innate immunity
The Self-Regulated Growth of Supermassive Black Holes
We present a series of simulations of the self--regulated growth of
supermassive black holes (SMBHs) in galaxies via three different fueling
mechanisms: major mergers, minor mergers, and disk instabilities. The SMBHs in
all three scenarios follow the same black hole fundamental plane (BHFP) and
correlation with bulge binding energy seen in simulations of major mergers, and
observed locally. Furthermore, provided that the total gas supply is
significantly larger than the mass of the SMBH, its limiting mass is not
influenced by the amount of gas available or the efficiency of black hole
growth. This supports the assertion that SMBHs accrete until they reach a
critical mass at which feedback is sufficient to unbind the gas locally,
terminating the inflow and stalling further growth. At the same time, while
minor and major mergers follow the same projected correlations (e.g., the
and Magorrian relations), SMBHs grown via disk instabilities do
not, owing to structural differences between the host bulges. This finding is
supported by recent observations of SMBHs in pseudobulges and bulges in barred
systems, as compared to those hosted by classical bulges. Taken together, this
provides support for the BHFP and binding energy correlations as being more
"fundamental" than other proposed correlations in that they reflect the
physical mechanism driving the co-evolution of SMBHs and spheroids.Comment: 15 pages, 16 figures, accepted for publication in Ap
Improved Cosmological Constraints from Gravitational Lens Statistics
We combine the Cosmic Lens All-Sky Survey (CLASS) with new Sloan Digital Sky
Survey (SDSS) data on the local velocity dispersion distribution function of
E/S0 galaxies, , to derive lens statistics constraints on
and . Previous studies of this kind relied on a
combination of the E/S0 galaxy luminosity function and the Faber-Jackson
relation to characterize the lens galaxy population. However, ignoring
dispersion in the Faber-Jackson relation leads to a biased estimate of
and therefore biased and overconfident constraints on the
cosmological parameters. The measured velocity dispersion function from a large
sample of E/S0 galaxies provides a more reliable method for probing cosmology
with strong lens statistics. Our new constraints are in good agreement with
recent results from the redshift-magnitude relation of Type Ia supernovae.
Adopting the traditional assumption that the E/S0 velocity function is constant
in comoving units, we find a maximum likelihood estimate of --0.78 for a spatially flat unvierse (where the range reflects uncertainty
in the number of E/S0 lenses in the CLASS sample), and a 95% confidence upper
bound of . If instead evolves in accord
with extended Press-Schechter theory, then the maximum likelihood estimate for
becomes 0.72--0.78, with the 95% confidence upper bound
. Even without assuming flatness, lensing provides
independent confirmation of the evidence from Type Ia supernovae for a nonzero
dark energy component in the universe.Comment: 35 pages, 15 figures, to be published in Ap
Evolution of the Cluster Mass and Correlation Functions in LCDM Cosmology
The evolution of the cluster mass function and the cluster correlation
function from z = 0 to z = 3 are determined using 10^6 clusters obtained from
high-resolution simulations of the current best-fit LCDM cosmology (\Omega_m =
0.27, \sigma_8 = 0.84, h = 0.7). The results provide predictions for
comparisons with future observations of high redshift clusters. A comparison of
the predicted mass function of low redshift clusters with observations from
early Sloan Digital Sky Survey data, and the predicted abundance of massive
distant clusters with observational results, favor a slightly larger amplitude
of mass fluctuations (\sigma_8 = 0.9) and lower density parameter (\Omega_m =
0.2); these values are consistent within 1-\sigma with the current
observational and model uncertainties. The cluster correlation function
strength increases with redshift for a given mass limit; the clusters were more
strongly correlated in the past, due to their increasing bias with redshift -
the bias reaches b = 100 at z = 2 for M > 5 x 10^13 h^-1 M_sun. The
richness-dependent cluster correlation function, represented by the correlation
scale versus cluster mean separation relation, R0-d, is generally consistent
with observations. This relation can be approximated as R_0 = 1.7 d^0.6 h^-1
Mpc for d = 20 - 60 h^-1 Mpc. The R0-d relation exhibits surprisingly little
evolution with redshift for z < 2; this can provide a new test of the current
LCDM model when compared with future observations of high redshift clusters.Comment: 20 pages, 9 figures, accepted for publication in Ap
Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here, we show that multinucleate OIS cells originate mostly from failed mitosis. Prior to senescence, mutant H-RasV12 activation in primary human fibroblasts compromised mitosis, concordant with abnormal expression of mitotic genes functionally linked to the observed mitotic spindle and chromatin defects. Simultaneously, H-RasV12 activation enhanced survival of cells with damaged mitoses, culminating in extended mitotic arrest and aberrant exit from mitosis via mitotic slippage. ERK-dependent transcriptional upregulation of Mcl1 was, at least in part, responsible for enhanced survival and slippage of cells with mitotic defects. Importantly, mitotic slippage and oncogene signaling cooperatively induced senescence and key senescence effectors p21 and p16. In summary, activated Ras coordinately triggers mitotic disruption and enhanced cell survival to promote formation of multinucleate senescent cells
BRAF mutations may identify a clinically distinct subset of glioblastoma
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Prior studies examining the mutational landscape of GBM revealed recurrent alterations in genes that regulate the same growth control pathways. To this regard, ~ 40% of GBM harbor EGFR alterations, whereas BRAF variants are rare. Existing data suggests that gain-of-function mutations in these genes are mutually exclusive. This study was designed to explore the clinical, pathological, and molecular differences between EGFR- and BRAF-mutated GBM. We reviewed retrospective clinical data from 89 GBM patients referred for molecular testing between November 2012 and December 2015. Differences in tumor mutational profile, location, histology, and survival outcomes were compared in patients with EGFR- versus BRAF-mutated tumors, and microarray data from The Cancer Genome Atlas was used to assess differential gene expression between the groups. Individuals with BRAF-mutant tumors were typically younger and survived longer relative to those with EGFR-mutant tumors, even in the absence of targeted treatments. BRAF-mutant tumors lacked distinct histomorphology but exhibited unique localization in the brain, typically arising adjacent to the lateral ventricles. Compared to EGFR- and IDH1-mutant tumors, BRAF-mutant tumors showed increased expression of genes related to a trophoblast-like phenotype, specifically HLA-G and pregnancy specific glycoproteins, that have been implicated in invasion and immune evasion. Taken together, these observations suggest a distinct clinical presentation, brain location, and gene expression profile for BRAF-mutant tumors. Pending further study, this may prove useful in the stratification and management of GBM
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