Analysis of Photovoltaic Energy in the Eastern Kentucky Region and the Residential Financial Feasibility

A thesis proposal presented to the Faculty of the College of Business and Technology Morehead State University in partial fulfillment of the requirements for the Degree Master of Science by Joshua A. Johnson on April 25, 2018

An Occupation Based Intervention Protocol for Carpometacarpal Joint Arthroplasty

The carpometacarpal (CMC) joint is located at the base of thumb and, functionally, is the most important joint within the hand due to its extensive mobility and the importance it has on the dexterity of human prehension. Due to the hypermobility and high degrees of utilization of the CMC joint, it is a common area for increased pain, joint disease, and the development of arthritis. Arthritis can be a debilitating condition as it is associated with instability, deformities, and limited range of motion, which all impact engagement in activities of daily living and meaningful occupations. When conservative treatments and non-surgical interventions have been exhausted, in efforts to increase joint function and decrease pain, surgical intervention is often implemented, followed by rehabilitation. Presently, there is a lack of a research regarding the implementation of occupation-based treatment as the typical approach to treatment has been biomechanically based. Despite the general research of the benefits utilizing occupation in the treatment process, there is limited evidence regarding the use of occupation-based activities following a CMC joint arthroplasty. The purpose of this scholarly project was to develop an intervention protocol that utilized “occupation” as a medium in the therapy process for clients who have undergone a CMC joint arthroplasty. Traditionally, the biomechanical approach used intervention methods focused on improving range of motion, strength, and endurance. However, research regarding the use of occupation has provided support that inclusion of occupation can improve physical impairments (similar to the biomechanical approach), in addition to enhancing self-efficacy, self-esteem, motivation and role engagement. Three biomechanical approaches were identified through research which were used, analyzed, and integrated to form one universal approach to intervention. Occupation-based activities selected for the purpose of this protocol were carefully assessed and analyzed to correlate with the established biomechanical approach. Following a thorough review of literature to assess current rehabilitation protocols and approaches utilized in practice, it was determined that there was minimal focus on occupation and occupation-based interventions. The Model of Human Occupation (MOHO) and Occupational Adaptation (OA) Model were utilized to assist in the development of this protocol as both emphasize the importance of occupation, in addition to motivation, contexts, habits and routines, roles, and adaptation. This protocol was developed to be a clinical guide that is easy to use in practice that can be implemented in conjunction with current biomechanical approaches for the rehabilitation of clients’ who have undergone a CMC joint arthroplasty

A Smaller Radius for the Transiting Exoplanet WASP-10b

We present photometry of WASP-10 during the transit of its short-period Jovian planet. We employed the novel PSF-shaping capabilities the OPTIC camera mounted on the UH 2.2m telescope to achieve a photometric precision of 4.7e-4 per 1.3 min sample. With this new light curve, in conjunction with stellar evolutionary models, we improve on existing measurements of the planetary, stellar and orbital parameters. We find a stellar radius Rstar = 0.698 +/- 0.012 Rsun and a planetary radius Rp = 1.080 +/- 0.020 Rjup. The quoted errors do not include any possible systematic errors in the stellar evolutionary models. Our measurement improves the precision of the planet's radius by a factor of 4, and revises the previous estimate downward by 16% (2.5sigma, where sigma is the quadrature sum of the respective confidence limits). Our measured radius of WASP-10b is consistent with previously published theoretical radii for irradiated Jovian planets.Comment: 4 pages, 2 tables, 2 figures, table 1 available upon reques

A Third Exoplanetary System with Misaligned Orbital and Stellar Spin Axes

We present evidence that the WASP-14 exoplanetary system has misaligned orbital and stellar-rotational axes, with an angle lambda = 33.1 +/- 7.4 deg between their sky projections. The evidence is based on spectroscopic observations of the Rossiter-McLaughlin effect as well as new photometric observations. WASP-14 is now the third system known to have a significant spin-orbit misalignment, and all three systems have "super-Jupiter" planets (M_P > 3 Mjup) and eccentric orbits. This finding suggests that the migration and subsequent orbital evolution of massive, eccentric exoplanets is somehow different from that of less massive close-in Jupiters, the majority of which have well-aligned orbits.Comment: 8 pages, 5 figures, 3 tables, PASP accepte

Improving risk estimates for metabolically healthy obesity and mortality using a refined healthy reference group

Objective: We aimed to re-examine mortality risk estimates for metabolically healthy obesity by using a ‘stable’ healthy non-obese referent group. Design: prospective cohort study. Methods: Participants were 5,427 men and women (aged 65.9 ± 9.4 years, 45.9% men) from the English Longitudinal Study of Ageing. Obesity was defined as body mass index ≥ 30 kg/m2 (vs. non-obese as below this threshold). Based on blood pressure, HDL-cholesterol, triglycerides, glycated haemoglobin, and C-reactive protein, participants were classified as ‘healthy’ (0 or 1 metabolic abnormality) or ‘unhealthy’ (≥ 2 metabolic abnormalities). Results: 671 deaths were observed over an average follow up of 8 years. When defining the referent group based on 1 clinical assessment, the unhealthy non-obese (Hazard ratio = 1.22; 95% CI, 1.01, 1.45) and unhealthy obese (1.29; 1.05, 1.60) were at greater risk of all-cause mortality compared to the healthy non-obese, yet no excess risk was seen in the healthy obese (1.14; 0.83, 1.52). When we re-defined the referent group based on 2 clinical assessments, effect estimates were accentuated and healthy obesity was at increased risk of mortality (2.67; 1.64, 4.34). Conclusion: An unstable healthy referent group may make ‘healthy obesity’ appear less harmful by obscuring the benefits of remaining never obese without metabolic dysfunction

Parameter Estimation from Time-Series Data with Correlated Errors: A Wavelet-Based Method and its Application to Transit Light Curves

We consider the problem of fitting a parametric model to time-series data that are afflicted by correlated noise. The noise is represented by a sum of two stationary Gaussian processes: one that is uncorrelated in time, and another that has a power spectral density varying as $1/f^\gamma$. We present an accurate and fast [O(N)] algorithm for parameter estimation based on computing the likelihood in a wavelet basis. The method is illustrated and tested using simulated time-series photometry of exoplanetary transits, with particular attention to estimating the midtransit time. We compare our method to two other methods that have been used in the literature, the time-averaging method and the residual-permutation method. For noise processes that obey our assumptions, the algorithm presented here gives more accurate results for midtransit times and truer estimates of their uncertainties.Comment: Accepted in ApJ. Illustrative code may be found at http://www.mit.edu/~carterja/code/ . 17 page

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover.

Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood. We recently identified protein palmitoylation as a mechanism regulating desmosome dynamics. In this study, we have focused on the palmitoylation of the desmosomal cadherin desmoglein-2 (Dsg2) and characterized the role that palmitoylation of Dsg2 plays in its localization and stability in cultured cells. We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that, when mutated, eliminate its palmitoylation. These cysteine residues are conserved in all four desmoglein family members. Although mutant Dsg2 localizes to endogenous desmosomes, there is a significant delay in its incorporation into junctions, and the mutant is also present in a cytoplasmic pool. Triton X-100 solubility assays demonstrate that mutant Dsg2 is more soluble than wild-type protein. Interestingly, trafficking of the mutant Dsg2 to the cell surface was delayed, and a pool of the non-palmitoylated Dsg2 co-localized with lysosomal markers. Taken together, these data suggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane. Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics

A Prograde, Low-Inclination Orbit for the Very Hot Jupiter WASP-3b

We present new spectroscopic and photometric observations of the transiting exoplanetary system WASP-3. Spectra obtained during two separate transits exhibit the Rossiter-McLaughlin (RM) effect and allow us to estimate the sky-projected angle between the planetary orbital axis and the stellar rotation axis, lambda = 3.3^{+2.5}_{-4.4} degrees. This alignment between the axes suggests that WASP-3b has a low orbital inclination relative to the equatorial plane of its parent star. During our first night of spectroscopic measurements, we observed an unexpected redshift briefly exceeding the expected sum of the orbital and RM velocities by 140 m/s. This anomaly could represent the occultation of material erupting from the stellar photosphere, although it is more likely to be an artifact caused by moonlight scattered into the spectrograph.Comment: 23 pages, 4 figures, Accepted for publication in The Astrophysical Journal, Replacement includes revised citation

Development and Validation of the Five-Factor LAMBI Measure of God Representations

God representations are complex and there is no standard, relatively short, and easy to administer measure reflecting both anthropomorphic and abstract representations of God. We developed a new measure with five dimensions: Limitless, Authoritarian, Mystical, Benevolent, and Ineffable (the LAMBI scale). In Study 1, we used exploratory factor analysis to examine the factor structure of a preliminary list of 41 common adjectives that people might use to describe God. In Study 2, we identified the 25 best-fitting items, using confirmatory factor analysis to show that a five-factor model fit well, and began to validate the new scale using measures of religious commitment, individualistic spirituality, and Quest. In Study 3, we found the scale has good test-retest reliability. In Study 4, we examined the contribution of the LAMBI scales in predicting conservatism, values, and beliefs, above and beyond two existing measures of God representations. In Study 5, we used latent profile analysis to identify four response patterns across the five dimensions: Relational, Abstract, Unbelief, and Amorphous (no differences across the five dimensions) and show little relation between these profiles and religious group membership. We conclude that the LAMBI scale assesses important individual differences in thinking about God and can potentially be used to predict beliefs and social attitudes