Expert System-Based Exploratory Approach to Cost Modeling of Reinforced Concrete Office Building

Expert system is a conventional method that is in use in cost modeling, considering its advantage over traditional regression method. It is based on this fact, that this study aimed at deploying neural network in cost modeling of reinforced concrete office building. One hundred (100) samples were selected at random and divided into two; one part was used to develop network algorithm while the second part was used for model validation. Neural network was used to generate the model algorithm; the model is divided into 3 modules: the data optimization module, criteria selection with initializing and terminating modules. Regression analysis was carried out and model validated with Jackknife re-sampling technique. The colinearity analysis indicates high level of tolerance and -0.07403 lowest variation prediction quotients to 0.66639 highest variation quotients. Also the Regression coefficient (R-square) value for determining the model fitness is 0.034 with standard error of 0.048 this attest to the fitness of the model generated. The model is flexible in accommodating new data and variables, thus, it allows for regular updating

Joshua\u27s total conquest of Canaan: a theological rationale

Joshua 1-1

The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding

High risk types of human papillomavirus, such as type 18 (HPV-18), cause cervical carcinoma, one of the most frequent causes of cancer death in women worldwide. DNA replication is one of the central processes in viral maintenance, and the machinery involved is an excellent target for the design of antiviral therapy. The papillomaviral DNA replication initiation protein E1 has origin recognition and ATP-dependent DNA melting and helicase activities, and it consists of a DNA-binding domain and an ATPase/helicase domain. While monomeric in solution, E1 binds DNA as a dimer. Dimerization occurs via an interaction of hydrophobic residues on a single alpha-helix of each monomer. Here we present the crystal structure of the monomeric HPV-18 E1 DNA-binding domain refined to 1.8-A resolution. The structure reveals that the dimerization helix is significantly different from that of bovine papillomavirus type 1 (BPV-1). However, we demonstrate that the analogous residues required for E1 dimerization in BPV-1 and the low risk HPV-11 are also required for HPV-18 E1. We also present evidence that the HPV-18 E1 DNA-binding domain does not share the same nucleotide and amino acid requirements for specific DNA recognition as BPV-1 and HPV-11 E1

Letter from the Managing Editor

This is a letter from Managing Editor Joshua C. Stone

Sometimes It\u27s as Simple as Socks

Joshua Seethoff ’07 knows what it’s like to be on the streets

Guest Artist Series: Marilyn Nonken, September 20, 2013

This is the concert program of the uest Artist Series: Marilyn Nonken performance on Friday, September 20, 2013 at 8:00 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts. Works performed were Veils and Lightning by Joshua Fineberg, Cloches D'adieu, Et Une Sourire...11:14 AM (1 hour ago) by Tristan Murail, Grisaille and Tremors by Joshua Fineberg, and Territoires De L'oubli by Tristan Murail. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund

Raising an “Amoeba Army” to Fight a Deadly Intestinal Parasite

Senior biology and chemistry major Joshua Leitao investigates amebiasis via American Society of Microbiology research fellowship

Joshua & Judges and Work

Introduction to Joshua and Judges Conquest (Joshua 1-12) Joshua (Joshua 1) The Land (Joshua 2-12) Working the Land (Joshua 5) Conquering the Land (Joshua 6-12) Remembering God’s Presence in the Land (Joshua 4:1-9) Coordination (Joshua 13-22) Covenant (Joshua 23-24) Chaos (Judges 1-21) Failing the Driving (Out) Test (Judges 1-2) The Judges (Judges 3-16) Deborah (Judges 4-5) The Economic Effects of War (Judges 6:1-11) Gideon’s Ambivalent Leadership (Judges 6:12 – 8:35) The Judges’ Failure of Leadership (Judges 9-16) Israel Falls Apart (Judges 17-21) The prosperity gospel unmasked in early form (Judges 17) Human depravity and the complicity of religious authorities unveiled (Judges 18-21) Conclusions from Joshua and Judge

The revolutionary founding moments of a contra-Grierson tradition [review of: Post-revolution nonfiction film: building the Soviet and Cuban Nations by Joshua Malitsky, 2013]

“The revolutionary founding moments of a contra-Grierson tradition” Joshua Malitsky, Post-revolution nonfiction film: building the Soviet and Cuban Nations (Bloomington: Indiana University Press, 2013)