Concert recording 2013-04-27b

[Track 01]. Fantasia di concerto / Eduardo Boccalari -- [Track 02]. Apres un reve / Gabriel Faure -- [Track 03]. Arabesque / Joseph Turrin -- [Track 04]. Gabriel\u27s oboe / Ennio Morricone ; arranged by David Werden -- [Track 05]. Believe me if all those endearing young charms / Simone Mantia ; arranged by David Werden -- [Track 06]. St. James Infirmary / Joe Primrose ; arranged by Mike Forbes

Concert recording 2013-04-25a

[Track 01]. English madrigal suite. Late in my rash accounting ; [Track 02]. Rest, sweet nymphs ; [Track 03]. My bonny lass / Weelkes ; Pilkington ; Morley ; arranged by Michael Forbes -- [Track 04]. Auburn is the colour... / Michael Forbes -- [Track 05]. Royal garden blues / traditional ; arranged by Michael Forbes -- [Track 06]. Tuba juba duba / Terry Hutchinson -- [Track 07]. Allegro / Roger Jones -- [Track 08]. Now hear this! / Ray Dempsey -- [Track 09]. Pari intervallo / Arvo Part -- [Track 10]. To a wild rose / Edward MacDowell ; arranged by Lockhart -- [Track 11]. Kierkegaard / Meyer Kupferman -- [Track 12]. Bill Bailey / Hughie Cannon ; arranged by James Garrett

Concert recording 2015-04-26

[Track 01]. Catching shadows / Ivan Trevino -- [Track 02]. Variation in F-sharp minor, op. 24. Theme : Andante cantabile ; Variation I : Allegretto scherzando ; Variations III : Andante molto sostenuto ; Variation V : Vivo scherzando / Léon Stekke -- [Track 03]. Concerto in E minor. Allegro apassionoto / Felix Mendelssohn -- [Track 04]. Cantabile et presto / George Enesco -- [Track 05]. Poem / Charles Griffes -- [Track 06]. Legende / George Enesco -- [Track 07]. Violin concerto in A minor, op. 53. Allegro ma non troppo / Antonin Dvorâk -- [Track 08]. Fantasie concertante / Jacques Casérède

Concert recording 2013-03-31b

[Track 01]. Sweet Georgie fame / Blossom Dearie -- [Track 02]. Joy spring / Clifford Brown -- [Track 03]. Summer samba / Marcos Valle -- [Track 04]. Rhythm\u27ning / Thelonious Monk -- [Track 05]. One note samba / Antonio Carlos Jobim -- [Track 06]. In a sentimental mood / Duke Ellington -- [Track 07]. Recordame / Joe Henderson -- [Track 08]. Full house / Wes Montgomery -- [Track 09]. Cats and kittens / Peter Erskine -- [Track 10]. Primal prayer / Dan Haerle -- [Track 11]. Cookin\u27 Boox / Detroit Jackson

Bathymetry of Southeast Greenland From Oceans Melting Greenland (OMG) Data

Southeast Greenland has been a major participant in the ice sheet mass loss over the last several decades. Interpreting the evolution of glacier fronts requires information about their depth below sea level and ocean thermal forcing, which are incompletely known in the region. Here, we combine airborne gravity and multibeam echo sounding data from the National Aeronautics and Space Administration's Oceans Melting Greenland (OMG) mission with ocean probe and fishing boat depth data to reconstruct the bathymetry extending from the glacier margins to the edges of the continental shelf. We perform a three‐dimensional inversion of the gravity data over water and merge the solution with a mass conservation reconstruction of bed topography over land. In contrast with other parts of Greenland, we find few deep troughs connecting the glaciers to the sources of warm Atlantic Water, amidst a relatively uniform, shallow (350 m) continental shelf. The deep channels include the Kangerlugssuaq, Sermilik, Gyldenløve, and Tingmiarmiut Troughs

A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect

We conducted a preregistered multilaboratory project (k = 36; N = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the paradigmatic replication approach. Each laboratory implemented one of two procedures that was intended to manipulate self-control and tested performance on a subsequent measure of self-control. Confirmatory tests found a nonsignificant result (d = 0.06). Confirmatory Bayesian meta-analyses using an informed-prior hypothesis (δ = 0.30, SD = 0.15) found that the data were 4 times more likely under the null than the alternative hypothesis. Hence, preregistered analyses did not find evidence for a depletion effect. Exploratory analyses on the full sample (i.e., ignoring exclusion criteria) found a statistically significant effect (d = 0.08); Bayesian analyses showed that the data were about equally likely under the null and informed-prior hypotheses. Exploratory moderator tests suggested that the depletion effect was larger for participants who reported more fatigue but was not moderated by trait self-control, willpower beliefs, or action orientation.</p

Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation

Background: Reliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility of an assay based on cellular oxygen consumption rate (OCR) in predicting clinical islet autotransplant (IAT) insulin independence (II). IAT is an attractive model for evaluating characterization assays regarding their utility in predicting II due to an absence of confounding factors such as immune rejection and immunosuppressant toxicity. Methods: Membrane integrity staining (FDA/PI), OCR normalized to DNA (OCR/DNA), islet equivalent (IE) and OCR (viable IE) normalized to recipient body weight (IE dose and OCR dose), and OCR/DNA normalized to islet size index (ISI) were used to characterize autoislet preparations (n = 35). Correlation between pre-IAT islet product characteristics and II was determined using receiver operating characteristic analysis. Results: Preparations that resulted in II had significantly higher OCR dose and IE dose (p<0.001). These islet characterization methods were highly correlated with II at 6–12 months post-IAT (area-under-the-curve (AUC) = 0.94 for IE dose and 0.96 for OCR dose). FDA/PI (AUC = 0.49) and OCR/DNA (AUC = 0.58) did not correlate with II. OCR/DNA/ISI may have some utility in predicting outcome (AUC = 0.72). Conclusions: Commonly used assays to determine whether a clinical islet preparation is of high quality prior to transplantation are greatly lacking in sensitivity and specificity. While IE dose is highly predictive, it does not take into account islet cell quality. OCR dose, which takes into consideration both islet cell quality and quantity, may enable a more accurate and prospective evaluation of clinical islet preparations

Retreat of Humboldt Gletscher, North Greenland, Driven by Undercutting From a Warmer Ocean

Humboldt Gletscher is a 100‐km wide, slow‐moving glacier in north Greenland which holds a 19‐cm global sea level equivalent. Humboldt has been the fourth largest contributor to sea level rise since 1972 but the cause of its mass loss has not been elucidated. Multi‐beam echo sounding data collected in 2019 indicate a seabed 200 m deeper than previously known. Conductivity temperature depth data reveal the presence of warm water of Atlantic origin at 0°C at the glacier front and a warming of the ocean waters by 0.9 ± 0.1°C since 1962. Using an ocean model, we reconstruct grounded ice undercutting by the ocean, combine it with calculated retreat caused by ice thinning to floatation, and are able to fully explain the observed retreat. Two thirds of the retreat are caused by undercutting of grounded ice, which is a physical process not included in most ice sheet models

Live cell imaging during mechanical stretch

There is currently a significant interest in understanding how cells and tissues respond to mechanical stimuli, but current approaches are limited in their capability for measuring responses in real time in live cells or viable tissue. A protocol was developed with the use of a cell actuator to distend live cells grown on or tissues attached to an elastic substrate while imaging with confocal and atomic force microscopy (AFM). Preliminary studies show that tonic stretching of human bronchial epithelial cells caused a significant increase in the production of mitochondrial superoxide. Moreover, using this protocol, alveolar epithelial cells were stretched and imaged, which showed direct damage to the epithelial cells by overdistention simulating one form of lung injury in vitro. A protocol to conduct AFM nano-indentation on stretched cells is also provided