Behavioral synthesis from VHDL using structured modeling

This dissertation describes work in behavioral synthesis involving the development of a VHDL Synthesis System VSS which accepts a VHDL behavioral input specification and performs technology independent synthesis to generate a circuit netlist of generic components. The VHDL language is used for input and output descriptions. An intermediate representation which incorporates signal typing and component attributes simplifies compilation and facilitates design optimization.A Structured Modeling methodology has been developed to suggest standard VHDL modeling practices for synthesis. Structured modeling provides recommendations for the use of available VHDL description styles so that optimal designs will be synthesized.A design composed of generic components is synthesized from the input description through a process of Graph Compilation, Graph Criticism, and Design Compilation. Experiments were performed to demonstrate the effects of different modeling styles on the quality of the design produced by VSS. Several alternative VHDL models were examined for each benchmark, illustrating the improvements in design quality achieved when Structured Modeling guidelines were followed

Structured modeling for VHDL synthesis

This report will describe a proposed modeling style for the use of the VHSIC Hardware Description Language (VHDL) in design synthesis. We will describe the operations and underlying assumptions of four design models currently understood and used in practice by designers: combinational logic, functional descriptions (involving clocked components such as counters), register transfer (data path) descriptions, and behavioral (instruction set or processor) designs. We will illustrate the various uses of the VHDL description styles (structural, dataflow and behavioral) to represent characteristics of each of these design models. Emphasis is placed on how VHDL constructs should be used in order to synthesize optimal designs

VSS : a VHDL synthesis system

This report describes a register transfer synthesis system that allows a designer to interact with the design process. The designer can modify the compiled design by changing the input description, selecting optimization and mapping strategies, or graphically changing the generated design schematic. The VHDL language is used for input and output descriptions. An intermediate representation which incorporates signal typing and component attributes simplifies compilation and facilitates design optimization. The compilation process consists of two phases. First, a design composed of generic components is synthesized from the input description. Second, this design is translated into components from a particular library by a mapper and optimized by a logic optimizer. Redesign to new technologies can be accomplished by changing only the component library

Guidance and control strategies for aerospace vehicles

A simplified method of matched asymptotic expansions was developed where the common part in composite solution is generated as a polynomial in stretched variable instead of actually evaluating the same from the outer solution. This methodology was applied to the solution of the exact equations for three dimensional atmospheric entry problems. Compared to previous works, the present simplified methodology yields explicit analytical expressions for various components of the composite solution without resorting to any type of transcendental equations to be solved only by numerical methods. The optimal control problem arising in the noncoplanar orbital transfer employing aeroassist was also addressed

Revised structure of haemoventosin

The structure of the lichen pigment haemoventosin has been revised to 3,4,6,9-tetrahydro-5,10-dihydroxy-7-methoxy-3S-methyl-1,6,9-trioxo-1H-naphtho-[2,3-c]pyran (3), mainly on the basis of long-range δC/δH correlations observed in 2D HMBC NMR experiments and long-range δH/δD isotope effects observed in partial deuteriation experiments with 10-O-acetylhaemoventosin; ortho- and para-quinonoid structures were distinguished by means of the transacetylation inferred in the sodium dithionite reduction of 10-O-acetylhaemoventosin

Long term Ultra-Violet Variability of Seyfert galaxies

Flux variability is one of the defining characteristics of Seyfert galaxies, a class of active galactic nuclei (AGN). Though these variations are observed over a wide range of wavelengths, results on their flux variability characteristics in the ultra-violet (UV) band are very limited. We present here the long term UV flux variability characteristics of a sample of fourteen Seyfert galaxies using data from the International Ultraviolet Explorer acquired between 1978 and 1995. We found that all the sources showed flux variations with no statistically significant difference in the amplitude of UV flux variation between shorter and longer wavelengths. Also, the flux variations between different near-UV (NUV, 1850 - 3300 A) and far-UV (FUV, 1150 - 2000 A) passbands in the rest frames of the objects are correlated with no time lag. The data show indications of (i) a mild negative correlation of UV variability with bolometric luminosity and (ii) weak positive correlation between UV variability and black hole mass. At FUV, about 50% of the sources show a strong correlation between spectral indices and flux variations with a hardening when brightening behaviour, while for the remaining sources the correlation is moderate. In NUV, the sources do show a harder when brighter trend, however, the correlation is either weak or moderate.Comment: Accepted by Journal of Astrophysics and Astronom

Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity.

Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease with a characteristic clinical course in subcortical white matter; however, atypical presentations of brainstem involvement may be seen in rare cases. This review summarizes reports to date on brainstem involvement in SSPE, including the clinical course of disease, neuroimaging presentations, and guidelines for treatment. A comprehensive literature search was performed for English-language publications with keywords "subacute sclerosing panencephalitis" and "brainstem" using the National Library of Medicine PubMed database (March 1981-September 2017). Eleven articles focusing on SSPE of the brainstem were included. Predominant brainstem involvement remains uncharacteristic of SSPE, which may lead to misdiagnosis and poor outcome. A number of case reports have demonstrated brainstem involvement associated with other intracranial lesions commonly presenting in later SSPE stages (III and IV). However, brainstem lesions can appear in all stages, independent of higher cortical structures. The varied clinical presentations complicate diagnosis from a neuroimaging perspective. SSPE of the brainstem is a rare but important clinical entity. It may present like canonical SSPE or with unique clinical features such as absence seizures and pronounced ataxia. While SSPE generally progresses to the brainstem, it can also begin with a primary focus of infection in the brainstem. Awareness of varied SSPE presentations can aid in early diagnosis as well as guide management and treatment

The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog.

Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including impairments in prepulse inhibition and memory. We investigated BRAT rats and their parental strain, Long-Evans (LE) rats, in a social discrimination paradigm, which is an ethologically relevant animal test of cognitive deficits of schizophrenia based upon the natural preference of animals to investigate conspecifics. We also investigated the effects of the atypical antipsychotic, clozapine, and the putative antipsychotic, PD149163, a brain-penetrating neurotensin-1 agonist, on social discrimination in these rats. Adult rats were administered saline or one of the three doses of clozapine (0.1, 1.0, or 10 mg/kg) or PD149163 (0.1, 0.3, or 1.0 mg/kg), subcutaneously. Following drug administration, adult rats were exposed to a juvenile rat for a 4-min learning period. Animals were then housed individually for 30 min and then simultaneously exposed to the juvenile presented previously and a new juvenile for 4 min. Saline-treated LE rats, but not BRAT rats, exhibited intact social discrimination as evidenced by greater time spent exploring the new juvenile. The highest dose of clozapine and the two highest doses of PD149163 restored social discrimination in BRAT rats. These results provide further support for the utility of the BRAT rat as a genetic animal model relevant to schizophrenia and drug discovery. The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported