Rethinking Realism and Constructivism Through the Lenses of Themes and Ontological Primacy

If integrative pluralism in international relations theorising is the way forward, how can we still maintain some type of demarcation between pre-existing paradigms in order to not throw the baby out with the bath water? The notions of themes and ontological primacy provide a useful intervention in this regard. They both link realism and constructivism yet at the same time differentiate between the two enough to allow for the original free-standing paradigm to maintain its veracity and usefulness as an explanatory tool to explain the international order. This article promotes the idea that realism and constructivism engage with many similar themes; it is their ontologies and methodologies that are the key points of departure and are worth being further explored. The article concludes that taking the notion of ontological primacy seriously allows for much needed theoretical pluralism, while effectively maintaining the foundational moorings of longstanding international relations theories

Farm Women as Producers & Consumers in the 20th Century U.S. South

The intent of this thesis is to examine white, rural women of the South who were directly affected by home demonstration between 1920 - 1950 and to discuss their roles as producers and consumers in the expanding market economy. Home demonstration, a three-tiered bureaucratic agency that provided domestic education and production techniques to Southern women, played a major role in guiding women toward the expanding market economy. Agents often had to temper their programs in order to compromise with the women they served to accommodate rural restrictions on capital, capability, and confidence. By integrating rural women into a more modernized, less isolated, and more urbanized environment, home demonstration hoped to improve the lives of women through its focus on sanitation, nutrition, and efficiency within household production

World War I and Propaganda Poster Art: Comparing the United States and German Cases

      This paper looks at some similarities and differences between propaganda art used by Germany and the United States during World War I.  The first section briefly looks at aesthetic theory and addresses the philosophical question of whether war propaganda posters are, in fact, ‘art’ at all.  Then images of various posters that were popular and widely published by both nations are shown and discussed.  This paper concludes that while there are many thematic similarities between the posters used by both sides, there are also some important differences.  The most obvious difference between the German and American propaganda art was in regard to the overall tone of the posters and the colors used in the presentation. The images used have been downloaded from a reputable website that depicts reproductions of the posters that were used during WW1. Understanding the nature of the propaganda used by each side can help shed light on the attitudes and sentiments towards the war held by political elites and citizens alike

Importance and hurdles to drug discovery for neurological disease

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110873/1/ana23997.pd

Coulomb correlations effects on localized charge relaxation in the coupled quantum dots

We analyzed localized charge time evolution in the system of two interacting quantum dots (QD) (artificial molecule) coupled with the continuous spectrum states. We demonstrated that Coulomb interaction modifies relaxation rates and is responsible for non-monotonic time evolution of the localized charge. We suggested new mechanism of this non-monotonic charge time evolution connected with charge redistribution between different relaxation channels in each QD.Comment: 10 pages, 10 figure

Exploring \pp scattering in the \1N picture

In the large $N_c$ approximation to $QCD$, the leading \pp scattering amplitude is expressed as the sum of an infinite number of tree diagrams. We investigate the possibility that an adequate approximation at energies up to somewhat more than one $GeV$ can be made by keeping diagrams which involve the exchange of resonances in this energy range in addition to the simplest chiral contact terms. In this approach crossing symmetry is automatic but individual terms tend to drastically violate partial wave unitarity. We first note that the introduction of the $\rho$ meson in a chirally invariant manner substantially delays the onset of drastic unitarity violation which would be present for the {\it current algebra} term alone. This suggests a possibility of local (in energy) cancellation which we then explore in a phenomenological way. We include exchanges of leading resonances up to the $1.3 GeV$ region. However, unitarity requires more structure which we model by a four derivative contact term or by a low lying scalar resonance which is presumably subleading in the \1N expansion, but may nevertheless be important. The latter two flavor model gives a reasonable description of the phase shift $\delta^0_0$ up until around $860 MeV$, before the effects associated which the $K\bar{K}$ threshold come into play.Comment: 27 LaTex pages + 13 figures (also available in hard-copy

Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1

Precision management of fibrotic lung diseases is challenging due to their diverse clinical trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring. Here, we validated the accuracy of CMKLR1 as an imaging biomarker of the lung inflammation-fibrosis axis. By analyzing single-cell RNA sequencing datasets, we demonstrate

Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines

Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 β- D-glucopyranose-NH-CO-R putative GP inhibitors differing only in their R groups. CombiGlide and GOLD docking programs with different scoring functions were employed with the best performing methods combined in a “consensus scoring” approach to ranking of ligand binding affinities for the active site. Six selected candidates from the screening were then synthesized and their inhibitory potency was assessed both in vitro and ex vivo. Their inhibition constants’ values, in vitro, ranged from 5 to 377 µM while two of them were effective at causing inactivation of GP in rat hepatocytes at low µM concentrations. The crystal structures of GP in complex with the inhibitors were defined and provided the structural basis for their inhibitory potency and data for further structure based design of more potent inhibitors

CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department

Abstract Introduction Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension. Methods Multicenter randomized clinical trial. Eligible patients had 2 systolic blood pressure (SBP) measures ≥180 mmHg and no contraindications to nicardipine or labetalol. Before randomization, the physician specified a target SBP ± 20 mmHg (the target range: TR). The primary endpoint was the percent of subjects meeting TR during the initial 30 minutes of treatment. Results Of 226 randomized patients, 110 received nicardipine and 116 labetalol. End organ damage preceded treatment in 143 (63.3%); 71 nicardipine and 72 labetalol patients. Median initial SBP was 212.5 (IQR 197, 230) and 212 mmHg (IQR 200,225) for nicardipine and labetalol patients (P = 0.68), respectively. Within 30 minutes, nicardipine patients more often reached TR than labetalol (91.7 vs. 82.5%, P = 0.039). Of 6 BP measures (taken every 5 minutes) during the study period, nicardipine patients had higher rates of five and six instances within TR than labetalol (47.3% vs. 32.8%, P = 0.026). Rescue medication need did not differ between nicardipine and labetalol (15.5 vs. 22.4%, P = 0.183). Labetalol patients had slower heart rates at all time points (P \u3c 0.01). Multivariable modeling showed nicardipine patients were more likely in TR than labetalol patients at 30 minutes (OR 2.73, P = 0.028; C stat for model = 0.72) Conclusions Patients treated with nicardipine are more likely to reach the physician-specified SBP target range within 30 minutes than those treated with labetalol. Trial registration ClinicalTrials.gov: NCT0076564