Process in Reality: A logical offering

The conjunction of process and reality is familiar from the original theory of A. N. Whitehead and the subsequent development of process philosophy and metaphysics by Nicholas Rescher. Classical logic, however, is either ignored or stated to be inappropriate to a discussion of process. In this paper, I will show that the value of a process view of reality can be enhanced by reference to a new, transconsistent logic of reality that is grounded in the physical properties of energy in its various forms. These properties justify a principle of dynamic antagonism or opposition that explicates the phenomena of change at all levels of reality. It can be, accordingly, a preferred logic for understanding the dynamics of real processes

Paying the Pied Piper: An Examination of Internet Service Provider Liability for Third Party Speech

No invention since the telephone has had as great an impact on the way society communicates as the internet. Through the internet more than two billion people explore new worlds, go to places they never could have imagined, attain knowledge otherwise unavailable, and communicate with people otherwise unreachable.  However, opening new channels of communication is just the beginning of the potential capabilities of the internet.

The philosophical logic of Stéphane Lupasco (1900–1988)

The advent of quantum mechanics in the early 20 th Century had profound consequences for science and mathematics, for philosophy (Schrödinger), and for logic (von Neumann). In 1968, Putnam wrote that quantum mechanics required a revolution in our understanding of logic per se. However, applications of quantum logics have been little explored outside the quantum domain. Dummett saw some implications of quantum logic for truth, but few philosophers applied similar intuitions to epistemology or ontology. Logic remained a truth-functional ’science’ of correct propositional reasoning.Starting in 1935, the Franco-Romanian thinker Stéphane Lupasco described a logical system based on the inherent dialectics of energy and accordingly expressed in and applicable to complex real processes at higher levels of reality. Unfortunately, Lupasco’s fifteen major publications in French went unrecognized by mainstream logic and philosophy, and unnoticed outside a Francophone intellectual community, albeit with some translations into other Romance languages. In English, summaries of Lupasco’s logic appeared ca. 2000, but the first major treatment and extension of his system was published in 2008 (see Brenner 2008). This paper is a further attempt to establish Lupasco’s concepts as significant contributions to the history and philosophy of logic, in line with the work of Gödel, general relativity, and the ontological turn in philosophy

The informational stance: Philosophy and logic. Part I. The basic theories

To better understand what information is and to explain information-related issues has become an essential philosophical task. General concepts from science, ethics and sociology are insufficient. As noted by Floridi, a new philosophy, a Philosophy of Information (PI), is needed. In the 80’s, Wu Kun proposed a “The Basic Theory of the Philosophy of Information”, which became available in English only in 2010. Wu and Joseph Brenner then found that the latter’s non-standard “Logic in Reality” provided critical logical support for Wu’s theory. In Part I of our paper, we outline the two basic theories as a metaphilosophy and metalogic for information. We offer our two theories as a further contribution to an informational paradigm. In Part II [WuB14], we develop the relation between information and social value as a basis for the ethical development of the emerging Information Society

The informational stance: Philosophy and logic. Part II. From physics to society

In Part I of our joint paper [WuB13], we outlined our respective theories, The Basic Theory of the Philosophy of Information (BTPI) and Logic in Reality (LIR) and showed their synergy for the understanding of complex informational processes. In this part, we develop Wu’s fundamental philosophical insight of the origin of the values of information in the interactions of complex information processing. A key concept in our work is that of a logical isomorphism between human individual and social value and the natural laws of the physical world. On the basis of Wu’s concept of Informational Thinking, we propose an Informational Stance, a philosophical stance that is most appropriate for, and not separated nor isolated from, the emerging unified theory of information. We propose our metaphilosophy and metalogic of information as further support for the ethical development of the Information Society

Quantifying Variation across 16S rRNA Gene Sequencing Runs in Human Microbiome Studies

Recent microbiome research has incorporated a higher number of samples through more participants in a study, longitudinal studies, and metanalysis between studies. Physical limitations in a sequencing machine can result in samples spread across sequencing runs. Here we present the results of sequencing nearly 1000 16S rRNA gene sequences in fecal (stabilized and swab) and oral (swab) samples from multiple human microbiome studies and positive controls that were conducted with identical standard operating procedures. Sequencing was performed in the same center across 18 different runs. The simplified mock community showed limitations in accuracy, while precision (e.g., technical variation) was robust for the mock community and actual human positive control samples. Technical variation was the lowest for stabilized fecal samples, followed by fecal swab samples, and then oral swab samples. The order of technical variation stability was inverse of DNA concentrations (e.g., highest in stabilized fecal samples), highlighting the importance of DNA concentration in reproducibility and urging caution when analyzing low biomass samples. Coefficients of variation at the genus level also followed the same trend for lower variation with higher DNA concentrations. Technical variation across both sample types and the two human sampling locations was significantly less than the observed biological variation. Overall, this research providing comparisons between technical and biological variation, highlights the importance of using positive controls, and provides semi-quantified data to better understand variation introduced by sequencing runs

Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock

IMPORTANCE: Aortic occlusion (AO) is a lifesaving therapy for the treatment of severe traumatic hemorrhagic shock; however, there remains controversy whether AO should be accomplished via resuscitative thoracotomy (RT) or via endovascular balloon occlusion of the aorta (REBOA) in zone 1. OBJECTIVE: To compare outcomes of AO via RT vs REBOA zone 1. DESIGN, SETTING, AND PARTICIPANTS: This was a comparative effectiveness research study using a multicenter registry of postinjury AO from October 2013 to September 2021. AO via REBOA zone 1 (above celiac artery) was compared with RT performed in the emergency department of facilities experienced in both procedures and documented in the prospective multicenter Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) registry. Propensity score matching (PSM) with exact institution matching was used, in addition to subgroup multivariate analysis to control for confounders. The study setting included the ED, where AO via RT or REBOA was performed, and participants were adult trauma patients 16 years or older. EXPOSURES: AO via REBOA zone 1 vs RT. MAIN OUTCOMES AND MEASURES: The primary outcome was survival. Secondary outcomes were ventilation-free days (VFDs), intensive care unit (ICU)-free days, discharge Glasgow Coma Scale score, and Glasgow Outcome Score (GOS). RESULTS: A total of 991 patients (median [IQR] age, 32 [25-48] years; 808 male individuals [81.9%]) with a median (IQR) Injury Severity Score of 29 (18-50) were included. Of the total participants, 306 (30.9%) had AO via REBOA zone 1, and 685 (69.1%) had AO via RT. PSM selected 112 comparable patients (56 pairs). REBOA zone 1 was associated with a statistically significant lower mortality compared with RT (78.6% [44] vs 92.9% [52]; P = .03). There were no significant differences in VFD greater than 0 (REBOA, 18.5% [10] vs RT, 7.1% [4]; P = .07), ICU-free days greater than 0 (REBOA, 18.2% [10] vs RT, 7.1% [4]; P = .08), or discharge GOS of 5 or more (REBOA, 7.5% [4] vs RT, 3.6% [2]; P = .38). Multivariate analysis confirmed the survival benefit of REBOA zone 1 after adjustment for significant confounders (relative risk [RR], 1.25; 95% CI, 1.15-1.36). In all subgroup analyses (cardiopulmonary resuscitation on arrival, traumatic brain injury, chest injury, pelvic injury, blunt/penetrating mechanism, systolic blood pressure ≤60 mm Hg on AO initiation), REBOA zone 1 offered an either similar or superior survival. CONCLUSIONS AND RELEVANCE: Results of this comparative effectiveness research suggest that REBOA zone 1 provided better or similar survival than RT for patients requiring AO postinjury. These findings provide the ethically necessary equipoise between these therapeutic approaches to allow the planning of a randomized controlled trial to establish the safety and effectiveness of REBOA zone 1 for AO in trauma resuscitation

Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography

Smoke inhalation injury is frequently accompanied by cyanide poisoning that may result in substantial morbidity and mortality, and methods are needed to quantitatively determine extent of airway injury. We utilized a 3-D endoscopic frequency-domain optical coherence tomography (FD-OCT) constructed with a swept-source laser to investigate morphological airway changes following smoke and cyanide exposure in rabbits. The thickness of the mucosal area between the epithelium and cartilage in the airway was measured and quantified. 3-D endoscopic FD-OCT was able to detect significant increases in the thickness of the tracheal walls of the rabbit beginning almost immediately after smoke inhalation injuries which were similar to those with combined smoke and cyanide poisoning

Assessment of fluorescent amplified fragment length polymorphism analysis for epidemiological genotyping of Legionella pneumophila serogroup 1

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