The Unmanly Fear: Extortion Before the Twentieth Century

This essay concerns the history of extortion in American law and culture, highlighting the shift from extortion as a paradigmatically male enterprise to one inseparably associated with women. Before the nineteenth-century, extortion was figured as an assault on a victim’s consent. Since men monopolized consent, extortion unfolded as a contest between legal subjects over political manhood. After the mid-nineteenth-century, a new class of ‘respectable’ victims, openly terrified by women’s threats, made unprecedented claims for legal protection. In response, well-placed courts wrote consent out of the equation, broadening the scope of extortionous threats to unleash the familiar fin-de-siècle tide of sex scandal

第665回 千葉医学会例会・第18回 佐藤外科例会 10.

Metabolic dysfunction is well-documented in Huntington's disease (HD). However, the link between the mutant huntingtin (mHTT) gene and the pathology is unknown. The tricarboxylic acid (TCA) cycle is the main metabolic pathway for the production of NADH for conversion to ATP via the electron transport chain (ETC). The objective of this study was to test for differences in enzyme activities, mRNAs and protein levels related to the TCA cycle between lymphoblasts from healthy subjects and from patients with HD. The experiments utilize the advantages of lymphoblasts to reveal new insights about HD. The large quantity of homogeneous cell populations permits multiple dynamic measures to be made on exactly comparable tissues. The activities of nine enzymes related to the TCA cycle and the expression of twenty-nine mRNAs encoding for these enzymes and enzyme complexes were measured. Cells were studied under baseline conditions and during metabolic stress. The results support our recent findings that the activities of the pyruvate dehydrogenase complex (PDHC) and succinate dehydrogenase (SDH) are elevated in HD. The data also show a large unexpected depression in MDH activities. Furthermore, message levels for isocitrate dehydrogenase 1 (IDH1) were markedly increased in in HD lymphoblasts and were responsive to treatments. The use of lymphoblasts allowed us to clarify that the reported decrease in aconitase activity in HD autopsy brains is likely due to secondary hypoxic effects. These results demonstrate the mRNA and enzymes of the TCA cycle are critical therapeutic targets that have been understudied in HD

Dr. Joseph Pepe, MD, President and Chief Executive Officer of CMC Healthcare System

The guest in this episode of The Health Leader Forge is Dr. Joseph Pepe, MD, President and Chief Executive Officer of Catholic Medical Center Healthcare System. Dr. Pepe has served the CMC Healthcare System since 1990, first as a staff physician, then as Chief Medical Officer, and since 2012 as the system President and CEO. The advice he gives early careerists entering the field of administration is to volunteer for additional responsibility, and that positions will follow. His own career reflects that fact. In the interview, Dr. Pepe describes his choice to become a primary care physician, and how his interest in improving the operations of the practice resulted in him being volun-told that he would be the Chief Medical Officer. After thirteen years of successful leadership as the Chief Medical Officer, Dr. Pepe was selected to lead CMC as the CEO and president. They discuss strategy and how Dr. Pepe is working with the board and senior management to ensure CMC\u27s success in a rapidly changing health care environment, while remaining true to CMC\u27s Catholic identity. They conclude with a discussion of leadership and mentorship

Transcriptional Regulation of Sphingosine Kinase 1

Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways. Sphingosine kinase 1, or SK1, is one of two sphingosine kinases that phosphorylate sphingosine into sphingosine-1-phosphate (S1P). S1P is generally pro-inflammatory, pro-angiogenic, immunomodulatory, and pro-survival; therefore, high SK1 expression and activity have been associated with certain inflammatory diseases and cancer. It is thus important to develop an understanding of the regulation of SK1 expression and activity. In this review, we explore the current literature on SK1 transcriptional regulation, illustrating a complex system of transcription factors, cytokines, and even micro-RNAs (miRNAs) on the post transcriptional level

Comparison of mRNA in healthy and HD lymphoblasts and their responses to serum deprivation and cyanide treatment (95% confidence interval).

<p>All changes are significant (p≤0.05) except for in the third column of panel C.</p

Patient criteria for selecting lymphoblast cultures.

<p>Patient criteria for selecting lymphoblast cultures.</p

Genes associated with the enzymes of the TCA cycle, PDHC and transketolase.

<p>Genes associated with the enzymes of the TCA cycle, PDHC and transketolase.</p