12 research outputs found

    Evaluation of the effects of Corchorus olitorius L. and Carapa procera in the treatment of obesity

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    Background: The obesity remains a pathology today which expands. It leads in its wake much pathology with very serious consequences. It is therefore necessary to take steps to curb this nutritional pathology. Thus, two plant species including Carapa procera and Corchorus olitorius have been tested to assess their effect on this pathology.Methods: Aqueous extracts of Carapa procera bark and Corchorus olitorius roots were tested on rats and biochemical parameters were evaluated. Besides, a chemical characterization was led.Results: These plant extracts contain bioactive molecules that have a regressive activity on the plasma levels of cholesterol, triglyceride and LDL-cholesterol. These bioactive molecules increase the level of HDL-cholesterol. These 2 species are non-toxic on renal, hepatic and pancreatic functions in view of the values of urea, creatinine and blood glucose.Conclusions: Of these 2 extracts, the aqueous extract of Corchorus olitorius is more active.

    Tri Phytochimique et Activités Antimicrobiennes des Extraits Hydroacétoniques de Baphia Nitida (Fabaceae) sur Shigella spp et E. coli, Deux Entérobactéries Impliquées dans les Diarrhées Infantiles à Daloa, Côte d’Ivoire

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    Introduction : Dans le but de contribuer Ă  une prise en charge efficiente des diarrhĂ©es infantiles et des troubles gastrointestinales, nous avons Ă©valuer les activitĂ©s antibactĂ©riennes des extraits des organes (feuilles tiges et racines) de Baphia nitida, une plante de la pharmacopĂ©e ivoirienne.  MĂ©thodes : Ainsi, un tri phytochimique des extraits hydroacĂ©toniques d’organes de B. nitida Ă  partir les rĂ©actions de prĂ©cipitations et de colorations suivi des tests de sensibilitĂ© antimicrobienne sur Shigella spp et E. coli ATCC 25922 ont Ă©tĂ© rĂ©alisĂ©s. Resultats : Les rĂ©sultats obtenus ont montrĂ© que les trois organes de plante Ă©taient riches en polyphĂ©nols, flavonoĂŻdes, alcaloĂŻdes et tanins cathĂ©chiques. En plus, les extraits des feuilles de B. nitida ont prĂ©sentĂ© une plus grande diversitĂ© d’autres mĂ©tabolites secondaires faiblement reprĂ©sentĂ©s. Les extraits de B. nitida se sont revĂ©lĂ©s bactĂ©ricides pour les deux souches testĂ©es. Ces actions seraient dose –dĂ©pendante avec une inhibition maximale Ă  c =.200 mg/mL. Les extraits des feuilles ont montrĂ© une activitĂ© antibactĂ©rienne plus efficace que les extraits de tiges, eux mĂŞmes plus actifs que les extraits de racines. Conclusion : Les souches d’E. coli testĂ©es se sont revelĂ©es plus sensibles que celles de Shigella spp pour les trois types d’organes de B. nitida. Les extraits des organes de B. nitida (en particulier les feuilles) pourraient constituer une alternative pour le traitement des diarrhĂ©es et une nouvelle source de molĂ©cules naturelles antiinfectieuses.   Introduction : In order to contribute to an efficient management of infantile diarrhea and gastrointestinal disorders, we evaluated the antibacterial activities of extracts of organs (leaves, stems and roots) of Baphia nitida, a plant of the Ivorian pharmacopoeia. Methods : Thus, a phytochemical screening of hydroacetone extracts of B. nitida organs based on precipitations and staining reactions followed by antimicrobial susceptibility tests on Shigella spp and E. coli ATCC 25922 were performed. Results : The results obtained revealed that the three plant organs were abundant in polyphenols, flavonoids, alkaloids and catechic tannins. In addition, the extracts from the leaves of B. nitida exhibited a greater diversity of other secondary metabolites that were weakly represented. B. nitida extracts were found to be bactericidal for both strains tested. These actions appeared to be dose-dependent with maximum inhibition at c = 200 mg/mL. The leaf extracts showed a more effective antibacterial activity than the stem extracts, which were more effective than the root extracts. Conclusion : The E. coli strains tested were more sensitive than Shigella spp. for all three types of B. nitida organs. The extracts of B. nitida organs (especially the leaves) could be an alternative for the treatment of diarrhoea and a new source of natural antibacterial molecules

    Tri phytochimique et activité antibactérienne des extraits hydroacétoniques de Baphia nitida (Fabaceae) sur Shigella spp et E. coli, deux entérobactéries impliquées dans les diarrhées infantiles à Daloa, Côte d’Ivoire

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    Introduction : Dans le but de contribuer Ă  une prise en charge efficiente des diarrhĂ©es infantiles et des troubles gastrointestinales, nous avons Ă©valuĂ© l’activitĂ© antibactĂ©rienne des extraits des organes (feuilles tiges et racines) de Baphia nitida, une plante de la pharmacopĂ©e ivoirienne. MĂ©thodes : Ainsi, un tri phytochimique des extraits hydroacĂ©toniques d’organes de B. nitida Ă  partir des rĂ©actions de prĂ©cipitations et de colorations suivi des tests de sensibilitĂ© antimicrobienne sur Shigella spp et E. coli ATCC 25922 ont Ă©tĂ© rĂ©alisĂ©s. Resultats : Les rĂ©sultats obtenus ont montrĂ© que les trois organes de plante Ă©taient riches en polyphĂ©nols, flavonoĂŻdes, alcaloĂŻdes et tanins cathĂ©chiques. En plus, les extraits des feuilles de B. nitida ont prĂ©sentĂ© une plus grande diversitĂ© avec d’autres mĂ©tabolites secondaires qui Ă©taient faiblement reprĂ©sentĂ©s. Les extraits de B. nitida se sont revĂ©lĂ©s bactĂ©ricides pour les deux souches testĂ©es. Ces actions seraient dose –dĂ©pendante avec une inhibition maximale Ă  c = 100 mg/mL. Les extraits des feuilles ont montrĂ© une activitĂ© antibactĂ©rienne plus efficace que les extraits de tiges, eux mĂŞmes plus actifs que les extraits de racines. Conclusion : Les souches d’E. coli testĂ©es se sont revelĂ©es plus sensibles que celles de Shigella spp pour les trois types d’organes de B. nitida. Les extraits des organes de B. nitida (en particulier les feuilles) pourraient constituer une alternative pour le traitement des diarrhĂ©es et une nouvelle source de molĂ©cules naturelles antiinfectieuses.   Introduction : In order to contribute to an efficient management of infantile diarrhea and gastrointestinal disorders, we evaluated the antibacterial activities of extracts of organs (leaves, stems and roots) of Baphia nitida, a plant of the Ivorian pharmacopoeia. Methods : Thus, a phytochemical screening of hydroacetone extracts of B. nitida organs based on precipitations and staining reactions followed by antimicrobial susceptibility tests on Shigella spp and E. coli ATCC 25922 were performed. Results : The results obtained revealed that the three plant organs were abundant in polyphenols, flavonoids, alkaloids and catechic tannins. In addition, the extracts from the leaves of B. nitida exhibited a greater diversity of other secondary metabolites that were weakly represented. B. nitida extracts were found to be bactericidal for both strains tested. These actions appeared to be dose-dependent with maximum inhibition at c = 100 mg/mL. The leaves extracts showed a more effective antibacterial activity than the stem extracts, which were more effective than the root extracts. Conclusion : The E. coli strains tested were more sensitive than Shigella spp. for all three types of B. nitida organs. The extracts of B. nitida organs (especially the leaves) could be an alternative for the treatment of diarrhoea and a new source of natural antibacterial molecules

    Tri Phytochimique et Activités Antimicrobiennes des Extraits Hydroacétoniques de Baphia Nitida (Fabaceae) sur Shigella spp et E. coli, Deux Entérobactéries Impliquées dans les Diarrhées Infantiles à Daloa, Côte d’Ivoire

    Get PDF
    Introduction : Dans le but de contribuer Ă  une prise en charge efficiente des diarrhĂ©es infantiles et des troubles gastrointestinales, nous avons Ă©valuer les activitĂ©s antibactĂ©riennes des extraits des organes (feuilles tiges et racines) de Baphia nitida, une plante de la pharmacopĂ©e ivoirienne.  MĂ©thodes : Ainsi, un tri phytochimique des extraits hydroacĂ©toniques d’organes de B. nitida Ă  partir les rĂ©actions de prĂ©cipitations et de colorations suivi des tests de sensibilitĂ© antimicrobienne sur Shigella spp et E. coli ATCC 25922 ont Ă©tĂ© rĂ©alisĂ©s. Resultats : Les rĂ©sultats obtenus ont montrĂ© que les trois organes de plante Ă©taient riches en polyphĂ©nols, flavonoĂŻdes, alcaloĂŻdes et tanins cathĂ©chiques. En plus, les extraits des feuilles de B. nitida ont prĂ©sentĂ© une plus grande diversitĂ© d’autres mĂ©tabolites secondaires faiblement reprĂ©sentĂ©s. Les extraits de B. nitida se sont revĂ©lĂ©s bactĂ©ricides pour les deux souches testĂ©es. Ces actions seraient dose –dĂ©pendante avec une inhibition maximale Ă  c =.200 mg/mL. Les extraits des feuilles ont montrĂ© une activitĂ© antibactĂ©rienne plus efficace que les extraits de tiges, eux mĂŞmes plus actifs que les extraits de racines. Conclusion : Les souches d’E. coli testĂ©es se sont revelĂ©es plus sensibles que celles de Shigella spp pour les trois types d’organes de B. nitida. Les extraits des organes de B. nitida (en particulier les feuilles) pourraient constituer une alternative pour le traitement des diarrhĂ©es et une nouvelle source de molĂ©cules naturelles antiinfectieuses.   Introduction : In order to contribute to an efficient management of infantile diarrhea and gastrointestinal disorders, we evaluated the antibacterial activities of extracts of organs (leaves, stems and roots) of Baphia nitida, a plant of the Ivorian pharmacopoeia. Methods : Thus, a phytochemical screening of hydroacetone extracts of B. nitida organs based on precipitations and staining reactions followed by antimicrobial susceptibility tests on Shigella spp and E. coli ATCC 25922 were performed. Results : The results obtained revealed that the three plant organs were abundant in polyphenols, flavonoids, alkaloids and catechic tannins. In addition, the extracts from the leaves of B. nitida exhibited a greater diversity of other secondary metabolites that were weakly represented. B. nitida extracts were found to be bactericidal for both strains tested. These actions appeared to be dose-dependent with maximum inhibition at c = 200 mg/mL. The leaf extracts showed a more effective antibacterial activity than the stem extracts, which were more effective than the root extracts. Conclusion : The E. coli strains tested were more sensitive than Shigella spp. for all three types of B. nitida organs. The extracts of B. nitida organs (especially the leaves) could be an alternative for the treatment of diarrhoea and a new source of natural antibacterial molecules

    Laxative activities of Mareya micrantha (Benth.) MĂĽll. Arg. (Euphorbiaceae) leaf aqueous extract in rats

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    <p>Abstract</p> <p>Background</p> <p><it>Mareya micrantha </it>(Benth.) MĂĽll. Arg. (Euphorbiaceae) is a shrub that is commonly used in CĂ´te d'Ivoire (West Africa) for the treatment of constipation and as an ocytocic drug. The present study was carried out to investigate the laxative activity of <it>Mareya micrantha </it>in albino's Wistar rats.</p> <p>Methods</p> <p>Rats were divided in 5 groups of 5 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with leaf aqueous extract of <it>Mareya micrantha </it>at doses of 100, 200 and 400 mg/kg body weight (b.w.), <it>per os </it>respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the leaves aqueous extract of <it>Mareya micrantha </it>and castor oil were also evaluated on intestinal transit, intestinal fluid accumulation and ions secretion.</p> <p>Results</p> <p>Phytochemicals screening of the extract revealed the presence of flavonoids, alkaloids, tannins, polyphenols, sterols and polyterpenes. The aqueous extract of <it>Mareya micrantha </it>applied orally (100, 200 and 400 mg/kg; <it>p.o</it>.), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (<it>p.o</it>.) was similar to that of reference drug sodium picosulfate (5 mg/kg, <it>p.o</it>). The same doses of the extract (200 and 400 mg/kg, <it>p.o</it>.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 mL) (p < 0.01). Moreover, the extract induced a significant enteropooling and excretion of Cl<sup>-</sup>, Na<sup>+</sup>, K<sup>+ </sup>and Ca<sup>2+ </sup>in the intestinal fluid (p < 0.01).</p> <p>Conclusions</p> <p>The results showed that the aqueous extract of <it>Mareya micrantha </it>has a significant laxative activity and supports its traditional use in herbal medicine.</p

    Evaluation of the effects of Corchorus olitorius L. and Carapa procera in the treatment of obesity

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    Background: The obesity remains a pathology today which expands. It leads in its wake much pathology with very serious consequences. It is therefore necessary to take steps to curb this nutritional pathology. Thus, two plant species including Carapa procera and Corchorus olitorius have been tested to assess their effect on this pathology.Methods: Aqueous extracts of Carapa procera bark and Corchorus olitorius roots were tested on rats and biochemical parameters were evaluated. Besides, a chemical characterization was led.Results: These plant extracts contain bioactive molecules that have a regressive activity on the plasma levels of cholesterol, triglyceride and LDL-cholesterol. These bioactive molecules increase the level of HDL-cholesterol. These 2 species are non-toxic on renal, hepatic and pancreatic functions in view of the values of urea, creatinine and blood glucose.Conclusions: Of these 2 extracts, the aqueous extract of Corchorus olitorius is more active.
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