Waste and the Governance of Private and Public Property

Common law waste doctrine is often overlooked as antiquated and irrelevant. At best, waste doctrine is occasionally examined as a lens through which to evaluate evolutions in modern property theory. We argue here that waste doctrine is more than just a historical artifact. Rather, the principle embedded in waste doctrine underpins a great deal of property law generally, both common law and statutory, as well as the law governing oil and gas, water, and public trust resources. Seen for what it is, waste doctrine provides a fresh perspective on property, natural resources, and environmental law. In this Article, we excavate the old waste cases in multiple fields of property and natural resources law to make novel connections across these fields and demonstrate the doctrine\u27s continuing relevance for contemporary lawyers, legal theorists, and environmental advocates. The Article is unique in its articulation of a universal waste principle and its examination of how this principle facilitates communication and cooperative self-governance by and among owners of common property. It suggests that underenforcement of civil and administrative waste law in the context of common pool natural resources contributes to failures in modern law to respond to pressing environmental challenges

Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G

Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding. We have co-expressed soluble truncated forms of gE and gI in Chinese hamster ovary cells. Soluble gE-gI complexes can be purified from transfected cell supernatants using a purification scheme that is based upon the Fc receptor function of gE-gI. Using gel filtration and analytical ultracentrifugation, we determined that soluble gE-gI is a heterodimer composed of one molecule of gE and one molecule of gI and that gE-gI heterodimers bind hIgG with a 1:1 stoichiometry. Biosensor-based studies of the binding of wild type or mutant IgG proteins to soluble gE-gI indicate that histidine 435 at the CH2-CH3 domain interface of IgG is a critical residue for IgG binding to gE-gI. We observe many similarities between the characteristics of IgG binding by gE-gI and by rheumatoid factors and bacterial Fc receptors such as Staphylococcus aureus protein A. These observations support a model for the origin of some rheumatoid factors, in which they represent anti-idiotypic antibodies directed against antibodies to bacterial and viral Fc receptors

Sports Leadership and Administration Program Annual Report 2019-20

The SLA Program is designed to foster critical consciousness among future leaders in sport and preparation for successful pursuits in sport administration, marketing, finance, management, and recreation. Mission of the Program: The mission of the SLA Program is to cultivate equity-minded, character-driven, and transformational leaders who will positively improve society through sport. Vision Statement: The vision of the SLA Program is to be the premier space and place for producing life-changing and society-shifting leaders in sport

Trauma Sequelae in the Forensic Female Population: Working with Numbing Behaviors

Women in the forensic system have extensive trauma histories that present as harmful behaviors, both during confinement and post-release. Incarcerated women who have experienced sexual and intimate partner violence engage in a variety of numbing behaviors, including substance use, child neglect, self-injurious behavior, and sexual acting-out. This session will review the limitations of in-house trauma work, and help counselors tailor strategies to mitigate numbing with forensic population

Establishment of Best Practice Skills for Advanced Practice Nurses

Over the past two decades, nursing researchers have defined nurses’ perceptions of evidence-based practice as well as facilitators and barriers to its implementation . This project seeks to take the next step through a current assessment of registered and advanced-practice nurses’ assimilation of evidence-based practice as well as a current literature review of the research to clinical use gap. This is a cross-sectional, retrospective project. Through analysis of two self-administered questionnaires to both registered and advanced-practice clinical nurses as well as literature review findings, five recommendations for advanced-practice nurses were created. Ultimately, the goal of this project seeks to establish evidenced-based practice implementation strategies for advanced-practice nurses to effectively bridge research to the bedside. Areas of evidence-based practice implementation that remain unanswered or weakly executed provide a direction for research moving forward

Estratégias para atrair e reter educadores: O que a evidência diz?

A highly competent teacher workforce is a necessary foundation for improving children’s educational outcomes, especially for those who rely most on schools for their success. Yet in the United States, shortages in the teaching force have been growing across the country, reaching crisis proportions in some teaching fields— such as mathematics, science, and special education—and in locations where wages and working conditions are least attractive. We analyzed recent research and representative survey data to identify the drivers of teacher recruitment and retention. We also reviewed the policy literature to identify district, state, and federal policy strategies that have been effective at addressing the factors influencing teachers’ professional decisions. These policies include increasing their compensation and improving their preparation, professional support, and working conditions, as well as improving district and school management practices that otherwise create obstacles to recruitment and retention. La fuerza laboral docente que es muy competente es una base necesaria para mejorar los resultados educativos de los niños, especialmente para aquellos que dependen más de las escuelas para su éxito. Sin embargo, en los Estados Unidos, la escasez en la fuerza docente ha aumentado en todo el país, alcanzando proporciones de crisis en algunos campos de la enseñanza, como matemáticas, ciencias y educación especial, y en lugares donde los salarios y las condiciones de trabajo son menos atractivos. Analizamos investigaciones recientes y datos de encuestas representativas para identificar los impulsores del reclutamiento y la retención de docentes. También revisamos la literatura sobre políticas para identificar estrategias de políticas del distrito, estatales y federales que han sido efectivas para abordar los factores que influyen en las decisiones profesionales de los maestros. Estas políticas incluyen aumentar su compensación y mejorar su preparación, apoyo profesional y condiciones de trabajo, así como mejorar las prácticas de gestión escolar y del distrito que de otra manera crean obstáculos para el reclutamiento y la retención. La fuerza laboral docente que es muy competente es una base necesaria para mejorar los resultados educativos de los niños, especialmente para aquellos que dependen más de las escuelas para su éxito. Sin embargo, en los Estados Unidos, la escasez en la fuerza docente ha aumentado en todo el país, alcanzando proporciones de crisis en algunos campos de la enseñanza, como matemáticas, ciencias y educación especial, y en lugares donde los salarios y las condiciones de trabajo son menos atractivos. Analizamos investigaciones recientes y datos de encuestas representativas para identificar los impulsores del reclutamiento y la retención de docentes. También revisamos la literatura sobre políticas para identificar estrategias de políticas del distrito, estatales y federales que han sido efectivas para abordar los factores que influyen en las decisiones profesionales de los maestros. Estas políticas incluyen aumentar su compensación y mejorar su preparación, apoyo profesional y condiciones de trabajo, así como mejorar las prácticas de gestión escolar y del distrito que de otra manera crean obstáculos para el reclutamiento y la retención.

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease.

The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear if specific hippocampal synapses are particularly vulnerable. Since the mossy fiber (MF) synapse between dentate gyrus (DG) and CA3 regions underlies critical functions disrupted in AD, we utilized serial block-face electron microscopy (SBEM) to analyze MF microcircuitry in a mouse model of familial Alzheimer's disease (FAD). FAD mutant MF terminal complexes were severely disrupted compared to control - they were smaller, contacted fewer postsynaptic spines and had greater numbers of presynaptic filopodial processes. Multi-headed CA3 dendritic spines in the FAD mutant condition were reduced in complexity and had significantly smaller sites of synaptic contact. Significantly, there was no change in the volume of classical dendritic spines at neighboring inputs to CA3 neurons suggesting input-specific defects in the early course of AD related pathology. These data indicate a specific vulnerability of the DG-CA3 network in AD pathogenesis and demonstrate the utility of SBEM to assess circuit specific alterations in mouse models of human disease

Modulation of Natural Killer Cell Cytotoxicity in Human Cytomegalovirus Infection: The Role of Endogenous Class I Major Histocompatibility Complex and a Viral Class I Homolog

Natural killer (NK) cells have been implicated in early immune responses against certain viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major histocompatibility complex (MHC) expression in infected cells; however, it has been proposed that a class I MHC homolog encoded by CMV, UL18, may act as a surrogate ligand to prevent NK cell lysis of CMV-infected cells. In this study, we examined the role of UL18 in NK cell recognition and lysis using fibroblasts infected with either wild-type or UL18 knockout CMV virus, and by using cell lines transfected with the UL18 gene. In both systems, the expression of UL18 resulted in the enhanced killing of target cells. We also show that the enhanced killing is due to both UL18-dependent and -independent mechanisms, and that the killer cell inhibitory receptors (KIRs) and CD94/NKG2A inhibitory receptors for MHC class I do not play a role in affecting susceptibility of CMV-infected fibroblasts to NK cell–mediated cytotoxicity